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Content measurement method for Lingqijia oral solution

A determination method and technology of oral liquid, which is applied in the field of detection of the content of Lingqijia oral liquid, can solve the problems of complicated steps, high toxicity, high cost, etc., and achieve the effect of short washing time, small relative deviation and high accuracy

Inactive Publication Date: 2015-09-23
HEILONGJIANG ZBD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Generally speaking, the use of chloroform organic reagent in the experimental steps of preparing the test product in the prior art has high toxicity, high cost, and complicated steps, which are not conducive to experimental research and drug production and inspection.
The content determination method is a thin-layer chromatography analysis method, and its precision and accuracy need to be improved

Method used

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  • Content measurement method for Lingqijia oral solution
  • Content measurement method for Lingqijia oral solution
  • Content measurement method for Lingqijia oral solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Instruments and reagents

[0025] SEDEX75 (France), astragaloside IV reference substance, source: China Institute for the Control of Pharmaceutical and Biological Products, acetonitrile: chromatographically pure, and the rest are analytically pure.

[0026] 2. Chromatographic conditions

[0027] Use octadecylsilane bonded silica gel as filler (5μ, 150×4.6mm); use acetonitrile-water (30:70) as mobile phase; use evaporative light scattering for detection, and the number of theoretical plates is calculated according to the peak of astragaloside IV Should not be less than 3500.

[0028] 2.1 Preparation of reference substance solution: Take an appropriate amount of astragaloside IV reference substance, weigh it accurately, add methanol to make a solution containing 0.5mg per 1ml, and obtain it.

[0029] 2.2 Preparation of the test solution:

[0030] Precisely measure 25ml of Lingqijia oral liquid, shake and extract 3 times with water-saturated n-butanol, 30ml each time...

experiment example 1

[0078] Experimental Example 1: Comparative Test

[0079] Example 1 and Comparative Example 1 were used to detect the content of Lingqijia oral liquid, and the results are shown in Table 9.

[0080] Table 9: Content detection data of embodiment 1 and comparative example 1

[0081]

[0082] The results in Table 9 show that: compared with the prior art, the detection method provided by the present invention is more time-saving, less toxic, and the green detection result is more accurate, and the active ingredients are extracted efficiently.

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Abstract

The invention relates to a content measurement method for Lingqijia oral solution. The method comprises the following steps of creating a chromatographic condition, preparing a reference solution and preparing and detecting a test sample solution. The accuracy, the precision and the durability of the method for detecting content by adopting an evaporative light chromatograph are consistent with corresponding standards, so that the method is feasible.

Description

technical field [0001] The invention relates to a method for detecting compound prescriptions of traditional Chinese medicines, in particular to a method for detecting the content of Lingqijia oral liquid. Background technique [0002] Lingqijia oral liquid, in the National Drug Standards of the State Food and Drug Administration, WS-11254 (ZD-1254)-2002, it is stated that the assay method of the content is a thin-layer chromatography analysis method, and the preparation method of the test solution is Method: Accurately measure 30ml of this product, shake and extract 2 times with chloroform, 25ml each time, discard the chloroform solution, shake the water solution with n-butanol saturated with water, extract 3 times, 20ml each time, combine the n-butanol solution, Wash twice with ammonia test solution, 20ml each time, discard the ammonia test solution, evaporate the n-butanol solution to dryness, add 5ml of water to the residue to dissolve, pass through a D101 macroporous ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 方同华
Owner HEILONGJIANG ZBD PHARMA
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