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Oil-in-water emulsion composition and use thereof

The technology of an oil-in-water emulsion and composition is applied in the direction of dressing preparations, pharmaceutical formulations, cosmetic preparations, etc., which can solve the problems of phase separation, turbidity increase, and loss of transparency, etc., to maintain storage stability and The effect of transparency

Active Publication Date: 2017-09-08
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, when such a triterpene is made into a nano-dispersion to make it transparent, particle growth tends to increase over time during storage, and turbidity increases during storage, resulting in a problem that the transparency is significantly impaired.
In addition, there are problems that when particle growth occurs, aggregation and sedimentation of particles also occur, and in extreme cases, phase separation of active ingredients occurs, and it is desired to fundamentally eliminate these problems

Method used

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  • Oil-in-water emulsion composition and use thereof
  • Oil-in-water emulsion composition and use thereof

Examples

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Effect test

Embodiment

[0213] Hereinafter, although an Example demonstrates this invention more concretely, this invention is not limited to the following Example unless the summary is exceeded.

Embodiment (1

[0215] (Preparation of oil-in-water emulsion composition)

[0216] β-glycyrrhetinic acid (manufactured by Maruzen Pharmaceutical Co., Ltd.) 1.00 g, N-lauroyl sarcosinate isopropyl (manufactured by Ajinomoto, ELDEWSL-205) 20.00 g, high-purity soybean lecithin (manufactured by Tsuji Oil Co., Ltd., SLP-White ) 2.00 g was mixed and dissolved while stirring at 70° C., and this was used as an oil phase composition.

[0217] On the other hand, 6.00 g of polyglyceryl isostearate-10 (HLB=12) (manufactured by Nikko Chemical Industry Co., Ltd.) was dissolved in a mixed solution of 100.00 g of glycerin (manufactured by Wako Pure Chemical Industries) and purified water at 70° C., and the It acts as an aqueous phase composition. The amount of purified water is properly adjusted so that the total mass of the prepared emulsion composition reaches 200 g.

[0218] The water-phase composition and the oil-phase composition dissolved respectively were roughly emulsified at 60° C. at 500 rpm for ...

Embodiment (2

[0229] Except that in the above example (1), the amount of β-glycyrrhetinic acid in the oil phase composition is 2.00 g, the amount of N-lauroyl sarcosinate isopropyl ester is 4.00 g, and the amount of high-purity soybean lecithin is 4.00 g. g. Except that the amount of polyglyceryl isostearate-10 in the aqueous phase composition is 9.00 g, the emulsion and the subsequent skin external composition are prepared in the same way as in Example (1), which is used as the skin external composition ( 2).

[0230] In addition, the evaluation of the oil droplet size and turbidity was performed in exactly the same manner as in Example (1).

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Abstract

The invention discloses an oil-in-water emulsion composition, which contains an oil phase and a water phase comprising (a) pentacyclic triterpene, (b) N-acyl amino acid monoester and (c) lecithin.

Description

technical field [0001] The present invention relates to an oil-in-water emulsion composition and its use. Background technique [0002] C biosynthesized from squalene as a starting material 30 compounds are called triterpenes. Triterpene compounds are roughly classified into 4 types of dammarane-based, hopane-based, ornoxalane-based, lanostane-based, or cyclopine-based compounds according to the ring bonding method. [0003] Among them, the dammarane series is a compound group including tetracyclic compounds such as dammarane and euphorane, and pentacyclic compounds such as lupinane and oleane. In addition, among the compounds classified into the dammarane series, many compounds having pharmacological action or physiological activity are known. [0004] In particular, various dammarane-based compounds are known as main components of plant extracts exhibiting functions such as anti-inflammatory, moisturizing, whitening, anti-wrinkle, and antibacterial by use in cosmetics. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/63A61K8/06A61K8/37A61K8/44A61K8/55A61Q5/00A61Q19/00
CPCA61Q19/00A61K8/062A61K8/36A61K8/44A61K8/553A61K8/63A61Q5/006A61Q7/00
Inventor 荒河纯森干永田代朋子
Owner FUJIFILM CORP