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Composite nanomaterial of core-shell structure, preparation method thereof and application thereof

A technology of composite nanomaterials and core-shell structure, which can be applied to preparations for in vivo tests, medical preparations containing active ingredients, wave energy or particle radiation treatment materials, etc., which can solve the problem of reduced SERS activity and the inability of SERS reagents to be used for imaging Diagnostics, instability, etc.

Active Publication Date: 2015-09-30
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biological toxicity of silver nanomaterials is high, and its SERS activity is greatly reduced due to its easy oxidation.
Due to its potential toxicity and instability, SERS reagents prepared from a single silver nanoparticle are not suitable for imaging diagnosis in vivo

Method used

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  • Composite nanomaterial of core-shell structure, preparation method thereof and application thereof
  • Composite nanomaterial of core-shell structure, preparation method thereof and application thereof
  • Composite nanomaterial of core-shell structure, preparation method thereof and application thereof

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preparation example Construction

[0098] The present invention also provides a kind of preparation method of described composite nanomaterial, described method comprises the steps:

[0099] a) providing a first solution, a second solution, a third solution and a fourth solution, wherein,

[0100] The first solution comprises a first solvent and silver nanoparticles dissolved in the first solvent;

[0101] The second solution comprises a second solvent and a first Raman detection molecule dissolved in the second solvent;

[0102] The third solution comprises a third solvent and gold or platinum nanoparticles dissolved in the third solvent;

[0103] The fourth solution comprises a fourth solvent and a second Raman detection molecule dissolved in the fourth solvent;

[0104] b) under stirring conditions, mix the first solution and the second solution to obtain a first mixed solution containing silver nanoparticles modified by the first Raman detection molecule;

[0105] c) under stirring conditions, mix the th...

Embodiment 1

[0169] Example 1 Preparation of silver-gold nanostar structure and SERS imaging and photothermal therapy

[0170] making process:

[0171] 1. Prepare Ag nanoparticles with a particle size of 40 nm according to existing literature methods.

[0172] 2. Add 1 mL of an ethanol solution of aminothiophenol with a concentration of 0.5 mM to 10 mL of an aqueous solution of Ag nanoparticles with a concentration of 1 mM, stir for 60 min, collect it by centrifugation and wash it several times with deionized water, and redisperse it in 10 mL deionized water.

[0173] 3. To 10 mL of 1 mM HAuCl 4 10 microliters of 0.1M hydrochloric acid solution was added to the aqueous solution, and 1 mL of the above-mentioned Ag nanoparticle solution of modified aminothiophenol was added. After stirring for 2 minutes, 10 mM AgNO was added to it at the same time. 3 50 microliters of aqueous solution of 50 mM ascorbic acid and 10 microliters of aqueous solution of 50 mM ascorbic acid. After reacting for ...

Embodiment 2

[0184] Example 2 Preparation of silver-gold nanoparticle structure and SERS imaging and photothermal therapy

[0185] making process:

[0186] 1. Prepare Ag nanoparticles with a particle size of 20 nm according to existing literature methods.

[0187] 2. Add 1 mL of DTTC dimethyl sulfoxide solution with a concentration of 0.3 mM to 10 mL of an aqueous solution of Ag nanoparticles with a concentration of 0.1 mM, stir for 10 min, collect it by centrifugation and wash it with deionized water for several times, and then redisperse in 10 mL of deionized water.

[0188] 3. Add 1mL of an aqueous solution of 5nm gold nanoparticles with a concentration of 0.1mM to 10mL of the above-mentioned Ag nanoparticles solution for primary modification of DTTC, and stir for 20 minutes to obtain the structure of AgAu nanoparticles for primary modification of DTTC. The resultant was collected by centrifugation, washed several times with deionized water, and redispersed in 10 mL of deionized water...

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Abstract

The invention relates to a composite nanomaterial of a core-shell structure, a preparation method thereof and application thereof. The composite nanomaterial has a core-shell structure, and comprises silver nanoparticles serving as inner cores and gold and / or platinum layers serving as outer shells, the surfaces of the silver nanoparticles carry first raman detection molecules, the gold and / or platinum layers wrap the surfaces of the silver nanoparticles, and the outer surfaces, away from the silver nanoparticles, of the gold and / or platinum layers carry second raman detection molecules. The invention further discloses the preparation method and application of the composite nanomaterial. The composite nanomaterial is applied to the diagnosis and treatment process of tumors, and a novel multifunctional molecular probe with low toxicity, high stability, high SERS activity and a photo-thermal treatment effect can be obtained.

Description

technical field [0001] The invention relates to the field of materials, in particular to a composite nanomaterial with a core-shell structure and its preparation method and application. Background technique [0002] Multifunctional molecular probes based on nanomaterials have important applications in the diagnosis and treatment of major diseases such as malignant tumors. In particular, noble metal nanomaterials, such as gold, silver, and platinum, have become important SERS active substrate materials due to their advantages of simple preparation and good water solubility. It is well known that silver has the highest SERS activity among noble metal nanomaterials, and the SERS enhancement factor of silver is more than 3 orders of magnitude higher than that of gold or platinum under the same conditions. However, silver nanomaterials have high biological toxicity and are easily oxidized, which greatly reduces their SERS activity. Due to its potential toxicity and instability,...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K41/00
Inventor 曾乐勇吴爱国
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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