Print nozzle system and mixed spraying printing technology of adjustable soft hollow tube support

Abstract

The invention provides a print nozzle system and mixed spraying printing technology of an adjustable soft hollow tube support.The print nozzle system comprises five functional parts including a pneumatic power source, a feeding device, a mixing device, sprayers and a spraying device. A hollow circular pipe is formed in such a manner that a solution A is subjected to dispensing, mixing and spraying technology under effects of a solution B, a solution C and a solution D via the sprayers. A two-layer or multi-layer structure is constructed. Under the spraying effect, connection strength between / among layers can be increased. The print nozzle system and mixed spraying printing technology of the adjustable soft hollow tube have following beneficial effects: two solutions can be completely mixed; continuous structures of hollow or solid circular pipes can be printed and accumulated in order to form different structures in order to print and manufacture hollow circular pipes similar to blood vessels; a micro-channel structure in the interior of the support can be constructed in order to transfer nutrition and other substance in tissue engineering by repair of large tissue; and the print nozzle system and mixed spraying printing technology of the adjustable soft hollow tube can be extensively applied to construction of biological tissues in all kinds.

Description

technical field [0001] The invention belongs to the intersecting fields of mechanical automation, biotechnology and tissue engineering, and specifically relates to a mixed spray printing process of a printing nozzle system and an adjustable soft hollow tube support. Background technique [0002] Tissue engineering simulates the natural tissue structure and uses three elements such as cells, scaffolds, and growth factors to construct artificial tissues for the repair of damaged or degenerated tissues. Among them, the scaffold is the key to transport and position cells and growth factors in space. It not only needs to have a certain mechanical bearing capacity and water content, but also in the application of thick tissues and organs, in order to transport enough nutrients, growth factors, Oxygen, and excrete metabolic waste, so that cells can grow and fuse together to form large-scale tissues and organs, but the production and formation of vascularization with similar vascula...

AI Technical Summary

Problems solved by technology

[0003] The structure of hydrogels such as sodium alginate is similar to that of the extracellular matrix of living tissues, and has important properties such as good biocompatibility, biodegradability, low toxicity and immune protection, and the large amount of water in it can effectively It is widely used to prepare scaffolds to provide growth conditions for cells, but it is difficult to customize the internal tubular structure of large hydrogels.

Images