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Application of ganoderic acid A to anti-depression

An anti-depressant and ganoderma acid technology, applied in the direction of medical preparations containing active ingredients, plant raw materials, organic active ingredients, etc., to achieve the effect of ensuring reliability

Active Publication Date: 2015-11-04
罗永强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are more than 30 patents on the use of ganoderma acid A in the world, see the attached table, but there is no report on the use of the compound ganoderma acid A in the treatment of depression in the existing literature or invention patents

Method used

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  • Application of ganoderic acid A to anti-depression
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  • Application of ganoderic acid A to anti-depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Effect of Ganoderma Acid A on Tail Suspension Experiment of Animal Depression Model

[0045] Animal CD1 mouse, male, weighing 25-35 grams, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2011-0011. Animals were housed in separate cages with free access to water, and the feed was provided by the Experimental Animal Center of the Institute of Genetics, Chinese Academy of Sciences. The common feed that the experimental mice could eat was acceptable.

[0046] Test drug:

[0047] Ganoderma acid A was purchased from Shanghai Fusheng Industrial Co., Ltd., 10 mg package.

[0048] Ganoderma acid A mother solution: Ganoderic acid A is dissolved in a small amount of pure ethanol to obtain 20ug / ul, and then diluted before injection.

[0049] The positive control imipramine hydrochloride (Imipramine hydrochloride) is a product of Sigma Company, product number I7379, lot number O56K1380.

[0050] Experimental eq...

Embodiment 2

[0058] Embodiment 2 mouse forced swimming experiment

[0059] Animals were male CD1 mice, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2011-0011. One week before the experiment, the animals were reared in separate cages, the light and dark cycle was 12h / 12h, the room temperature was 20-22°C, and they were free to eat and drink. The feed was provided by the Experimental Animal Center of the Institute of Genetics, Chinese Academy of Sciences.

[0060] Experimental drug: Ganoderma acid A, imipramine hydrochloride (Imipramine hydrochloride) is the same as Example 1; Test apparatus: glass cylinder (high 20cm, diameter 14cm); Mouse open box (diameter 30cm, height 20cm, bottom 16 equal parts ); thermometer; JUNSO multi-function timer.

[0061] Drug preparation was the same as in Example 1 for the tail suspension experiment.

[0062] Ganoderma acid A mother solution: Dissolve Ganoderma acid A in ethanol to obtain a 20ug / ...

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Abstract

Use of a pharmacodynamic active ingredient of ganoderma lucidum in preparing anti-depressant drugs, and anti-depressant drugs comprising the pharmacodynamic active ingredient of ganoderma lucidum, the pharmacodynamic active ingredient being ganoderic acid A or a derivative of ganoderic acid A, the derivatives being glycoside compounds of ganoderic acid A with pharmaceutically acceptable salts, esters or sugar thereof.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to the application of ganoderma acid A in antidepressant. Background technique [0002] Depression has become a common and frequently-occurring disease in modern society, and its incidence is still increasing. Symptoms are characterized by depressed mood, loss of interest, slow thinking, and decreased speech and actions. Severe depression has world-weary or suicidal thoughts. The suffering caused by such diseases to patients and their families, as well as the loss to society, are unmatched by many other diseases. According to the report published by the World Health Organization (WHO), affective disorder has become the fourth largest disease in the world, and the number of depressed patients in the world has reached 340 million. The current incidence of depression in China is about 4%. At least 26 million people in China suffer from depression, and the total economic burden caused by depr...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61K31/575A61P25/24
CPCA61K31/575
Inventor 杜若甫
Owner 罗永强
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