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Rapid Diagnostic Test Strips

A technology for rapid diagnosis and test strips, applied in measuring devices, instruments, fluorescence/phosphorescence, etc., can solve the problem that colloidal gold immunochromatography test strips cannot meet clinical testing, colloidal gold test strips have low sensitivity and cannot reach Requirements and other issues to achieve high social and economic value, high sensitivity, and strong specificity

Inactive Publication Date: 2017-07-14
HANGZHOU JINXI BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, colloidal gold test strips have low sensitivity and are prone to false positives. Many substances that require high-sensitivity detection cannot meet the requirements using colloidal gold test strips.
Therefore, the detection method of colloidal gold immunochromatographic test strips can not meet the needs of many clinical detections, and is in urgent need of improvement.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1, a kind of rapid diagnosis test strip based on homogeneous chemiluminescence technology, comprises PVC bottom plate 1, sample pad 2, glass fiber pad 3, is coated with C line (that is, control line) 6 and T line (that is, Nitrocellulose membrane 4, absorbent pad 5 of test line) 7.

[0053] A nitrocellulose membrane 4 is fixedly arranged on the upper surface of the PVC base plate 1, and a glass fiber pad 3 and a water-absorbing pad 5 are respectively arranged on both sides of the nitrocellulose membrane 4; Except that the upper surface of the left end of 4 is fixedly connected, the remaining lower surface of the glass fiber pad 3 is fixedly connected with the upper surface of the PVC bottom plate 1; except that the lower surface of the left end of the absorbent pad 5 is fixedly connected with the upper surface of the right end of the nitrocellulose membrane 4 , the remaining lower surface of the absorbent pad 5 is fixedly connected to the upper surface of the...

Embodiment 2

[0074] Embodiment 2, a kind of rapid diagnosis test strip based on homogeneous chemiluminescent technology, comprises PVC bottom plate 1, sample pad 2, glass fiber pad 3, is coated with C line (that is, control line) 6 and T line (that is, Nitrocellulose membrane 4, absorbent pad 5 of test line) 7.

[0075] A nitrocellulose membrane 4 is fixedly arranged on the upper surface of the PVC base plate 1, and a glass fiber pad 3 and a water-absorbing pad 5 are respectively arranged on both sides of the nitrocellulose membrane 4; Except that the upper surface of the left end of 4 is fixedly connected, the remaining lower surface of the glass fiber pad 3 is fixedly connected with the upper surface of the PVC bottom plate 1; except that the lower surface of the left end of the absorbent pad 5 is fixedly connected with the upper surface of the right end of the nitrocellulose membrane 4 , the remaining lower surface of the absorbent pad 5 is fixedly connected to the upper surface of the ...

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Abstract

The invention discloses a rapid diagnosis test strip, which comprises a PVC bottom plate, a sample pad, a glass fiber pad, a nitrocellulose membrane coated with C-line and T-line, and a water-absorbing pad. The glass fiber mat is coated with acceptor microspheres coupled with specific antibody I; the T line of the nitrocellulose membrane is the donor microspheres coupled with specific antibody II, and the C line of the nitrocellulose membrane is the coupled microspheres. Donor microspheres linked to specific antibody III capable of binding to specific antibody I. Both the specific antibody I and the specific antibody II can specifically bind to the protein to be tested, and bind to different epitopes of the protein to be tested. The diagnostic test strip has the characteristics of strong specificity, high sensitivity, quickness, simplicity, quantification, and suitability for rapid diagnosis.

Description

technical field [0001] The invention relates to a rapid diagnosis test strip. Background technique [0002] Homogeneous chemiluminescence (Amplified Luminscent Proximity Homogeneous Assay, AlphaLISA) is a new type of immunoassay technology. Homogeneous chemiluminescence technology does not need to wash during the whole process, the operation is very simple and the sensitivity is high. Moreover, homogeneous chemiluminescence has a wide dynamic range (3-5 orders of magnitude), a large affinity range (antibodies with high and low affinity can be applied), strong anti-interference ability, and is easy to realize automation. It has been widely used in drug screening, and its detection principle is as follows: figure 1 shown. The donor microspheres with the dye, the acceptor microspheres coated with the active molecules and the luminescent compound, and the detection sample are mixed under homogeneous conditions. At this time, the donor microspheres and the acceptor microspher...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/76G01N21/64G01N33/558G01N33/544
Inventor 朱成钢贾亮
Owner HANGZHOU JINXI BIOLOGICAL TECH
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