Applications of niclosamide in preparing drugs used for preventing myopia
A technology of niclosamide and myopia, which is applied in the field of application of niclosamide in the preparation of drugs for preventing and treating myopia, and can solve the problems that the application of niclosamide has not been reported.
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Embodiment 1
[0027] Embodiment 1: the impact of niclosamide on the diopter of FDM mice (mouse form deprivation myopia model mice)
[0028] Experimental animals: SPF grade male C57BL / 6J mice (3-4 weeks old) were purchased from Nanjing University-Nanjing Institute of Biomedicine. Slit-lamp microscopy and infrared eccentric photorefractor (EIR) examination ruled out eye diseases, and mice with microphthalmia, corneal opacities, cataracts, and bilateral anisometropia were excluded. All mice were raised under SPF conditions before participating in the experiment, and were given 12 hours of light every day, the light intensity around the cage was 500 lux, the room temperature was controlled at (25±2°C), and adequate food and drinking water were given. After the experiment started, they were raised under normal-grade conditions and fed freely; the room temperature was controlled at 20-25°C, and the light intensity was 250-300lux.
[0029] Grouping: Mice were randomly divided into: control group,...
Embodiment 2
[0034] Embodiment 2: the impact of niclosamide on vitreous cavity depth (VCD) of FDM mice
[0035] Experimental animals: the same as in Example 1.
[0036] Grouping: with embodiment 1.
[0037] Modeling and administration: the same as in Example 1.
[0038] Vitreous cavity depth test method: use optical coherence tomography OCT (wavelength 1310nm, light source bandwidth 60nm, resolution accuracy 10μm) to measure ocular biological parameters (ZhouX, XieJFau-ShenM, ShenMFau-WangJ, et al.Biometricmeasurementofthemouseeyeusingopticalcoherencetomographywithfocalplaneadvancement.) The principle of the optical interferometer is to detect the back reflection or several scattered signals of the incident weak coherent light at different depths of the biological tissue. By scanning, the two-dimensional or three-dimensional structural image of the biological tissue can be obtained, which can be used for non-contact, Non-invasive tomography. OCT can measure various refractive parameters...
Embodiment 3
[0041] Example 3: Effect of Niclosamide on Axial Length (AL) of FDM Mice
[0042] Experimental animals: the same as in Example 1.
[0043] Grouping: with embodiment 1.
[0044] Modeling and administration: the same as in Example 1.
[0045] Measuring method of axial length of the eye: the optical coherence tomography OCT, testing and calculation methods as described in Example 2 are used to measure the axial length of the eye. Axial length was defined from the anterior surface of the cornea to the retinal nerve RGC cell layer.
[0046] Experimental results: As shown in Table 1, before the experiment, there was no significant difference in the axial length (AL) of the left and right eyes of the experimental animals within each group and between each group (P>0.05, paired t test, P>0.05, one-way analysis of variance) .
[0047] as table 2 and image 3 As shown, after 4 weeks of the experiment, the axial length of the deprived eye in the FDM group was increased by 0.048±0.00...
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