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Collagen porous film and preparation method thereof

A technology of porous film and collagen, applied in medical science, absorbent pads, bandages, etc., can solve the problems of increasing the burden on doctors and patients, prolonging the wound recovery period, and increasing the burden on patients, so as to achieve good fusion ability, promote wound healing, reduce The effect of medical expenses

Inactive Publication Date: 2015-11-11
SUZHOU YOUJUN ENVIRONMENTAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, after trauma surgery, wound recovery is a long process, and a little carelessness may lead to wound infection, which increases the burden on patients and prolongs the wound recovery period
In the prior art, doctors solve the above problems by regularly changing gauze and cooperating with antibiotic treatment. This method is more traditional and has better effect, but there are some shortcomings
For example, frequent use of antibiotics is likely to produce drug resistance, which is not conducive to health; in addition, frequent use of gauze is likely to cause waste of biological resources and increase the burden on doctors and patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A collagen porous membrane, mainly made of the following raw materials according to the ratio of parts by mass: 13 parts of chitosan, 12 parts of collagen, 11 parts of tricalcium phosphate, 12 parts of chitin, 8 parts of glutaraldehyde, polyether 1 part of sulfone, 1 part of sulfonated polyethersulfone, 2 parts of cellulose acetate, 8 parts of acetic acid, 25 parts of double distilled water.

[0027] A preparation method of a collagen porous membrane, comprising the following steps:

[0028] (1) Dissolve acetic acid in double-distilled water to prepare an acetic acid solution with a mass concentration of 0.05%, and dissolve chitosan, collagen and chitin in the acetic acid solution at a mass ratio of 3:1:0.5, and stir to mix evenly , to prepare the base liquid;

[0029] (2) Add tricalcium phosphate into the base liquid obtained in step (1), and stir until completely dissolved;

[0030] (3) Put polyethersulfone, sulfonated polyethersulfone and cellulose acetate in a rea...

Embodiment 2

[0034] A collagen porous membrane, mainly made of the following raw materials according to the ratio of parts by mass: 26 parts of chitosan, 24 parts of collagen, 17 parts of tricalcium phosphate, 22 parts of chitin, 13 parts of glutaraldehyde, polyether 14 parts of sulfone, 3 parts of sulfonated polyethersulfone, 11 parts of cellulose acetate, 18 parts of acetic acid, 52 parts of double distilled water.

[0035] A preparation method of a collagen porous membrane, comprising the following steps:

[0036] (1) Dissolve acetic acid in double distilled water to prepare an acetic acid solution with a mass concentration of 0.07%, and dissolve chitosan, collagen and chitin in acetic acid at a mass ratio of 3~7:1~3:0.5~5 In the solution, stir and mix evenly to obtain the base liquid;

[0037] (2) Add tricalcium phosphate into the base liquid obtained in step (1), and stir until completely dissolved;

[0038] (3) Put polyethersulfone, sulfonated polyethersulfone and cellulose acetate...

Embodiment 3

[0042] A collagen porous membrane, mainly made of the following raw materials according to the ratio of parts by mass: 30 parts of chitosan, 28 parts of collagen, 20 parts of tricalcium phosphate, 30 parts of chitin, 19 parts of glutaraldehyde, polyether 17 parts of sulfone, 7 parts of sulfonated polyethersulfone, 13 parts of cellulose acetate, 22 parts of acetic acid, 58 parts of double distilled water.

[0043] A preparation method of a collagen porous membrane, comprising the following steps:

[0044] (1) Dissolve acetic acid in double-distilled water to prepare an acetic acid solution with a mass concentration of 0.1%, and dissolve chitosan, collagen and chitin in the acetic acid solution at a mass ratio of 7:3:5, and mix well , to prepare the base liquid;

[0045] (2) Add tricalcium phosphate into the base liquid obtained in step (1), and stir until completely dissolved;

[0046] (3) Put polyethersulfone, sulfonated polyethersulfone and cellulose acetate in a reaction k...

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Abstract

The invention discloses a collagen porous film and a preparation method thereof. The collagen porous film is prepared by adopting the following raw materials in part by weight: 13 to 30 parts of chitosan, 12 to 28 parts of collagen, 11 to 20 parts of tricalcium phosphate, 12 to 30 parts of chitin, 8 to 19 parts of glutaraldehyde, 1 to 17 parts of polyether sulfone, 1 to 7 parts of sulfonated polyether sulfone, 2 to 13 parts of cellulose acetate, 8 to 22 parts of acetic acid and 25 to 58 parts of double distilled water. Compared with the prior art, the collagen porous film has the following advantages: (1) wound healing can be effectively promoted; (2) the collagen porous film is safe and non-toxic to use and has good fusion capacity with human cells; (3) the collagen porous film is low in manufacture cost, so that the medical cost can be reduced.

Description

technical field [0001] The invention relates to the field of new materials for bioengineering, in particular to a collagen porous membrane and a preparation method thereof. Background technique [0002] With the development of society and the progress of science, the mutual embedding and infiltration among disciplines have been caused. Biomedical materials science, produced by the interpenetration and development of modern life sciences, materials science, medicine, engineering and other disciplines, has attracted more and more attention with the improvement of people's health and quality of life standards, and has become A hotspot of competing research and development. Biomedical materials, also known as biomaterials, refer to new inanimate high-tech materials that are used for medical purposes to diagnose, treat, repair or replace damaged tissues and organs or enhance their functions. Biomaterials include tissue engineering materials, nano-biomaterials, biomineralized ma...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/42A61L15/28A61L15/44
Inventor 凌云金可心夏戊君凌天阳
Owner SUZHOU YOUJUN ENVIRONMENTAL SCI & TECH