Coiled-coil structure protein 8 capable of inhibiting HIV-1 and its application

A coiled-coil structure, HIV-1 technology, applied in the field of biomedicine, can solve problems such as drug resistance, inability to completely cure AIDS, and HIV side effects
CN105039348BActive Publication Date: 2019-01-01NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
NANKAI UNIV
Publication Date
2019-01-01

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Abstract

The invention relates to new coiled-coil domain containing protein 8 (CCDC8) having inhibition on HIV-1 and an application thereof. The CCDC8, which is generated by human cells, in the invention has a strong anti-HIV-1 effect. By means of combination of the CCDC8 with matrix protein region of HIV-1Gag, assembly of the Gag protein on cytomembrane is inhibited. The CCDC8, OBSL1, and E3 ubiquitin ligase Cul7 cause internalization, multi-ubiquitination and degradation of the HIV-1Gag. According to the invention, on the basis of the CCDC8, a new plasmid is established and can be used for express new proteins, namely, the protein composed of 274 amino acids at the N-terminal of the CCDC8, thereby degrading HIV-1.
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Description

technical field

[0001] The invention belongs to the field of biomedicine and relates to a novel protein capable of inhibiting HIV-1. Specifically, the anti-HIV-1 effect can be achieved by inducing polyubiquitination and degradation of HIV-1 Gag. Background technique

[0002] AIDS (Acquired Immune Deficiency Syndrome, AIDS) caused by Human Immunodeficiency Virus (Human Immunodeficiency Virus, HIV-1) or AIDS virus has been prevalent in the world for more than 30 years. AIDS is a severe infectious disease. The virus directly attacks the immune system of the human body, resulting in defective immune function of the human body, prone to opportunistic infections and tumors, and most of them die. According to the World Health Organization (WHO) report, by the end of 2013, there were about 35 million HIV-1 living infected people in the world, and about 30 million people had died, totaling about 65 million people. In 2013, about 2.1 million people were newly infected with HIV-1, and...

Claims

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