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A preparation method of dimethyl phthalate molecularly imprinted microspheres

A technology of dimethyl phthalate and dimethyl aminophthalate, which is applied in the field of molecularly imprinted polymers, can solve problems such as poor adsorption of recognition sites, and avoid gelation and embedding phenomenon, high association rate and dissociation efficiency, and the effect of high separation processing efficiency

Inactive Publication Date: 2017-03-08
ZHEJIANG FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In order to solve the problem of poor adsorption of recognition sites when molecular imprinting technology is used to detect dimethyl phthalate molecules, the present invention proposes a method for preparing dimethyl phthalate molecularly imprinted microspheres. The molecularly imprinted microspheres prepared by the method have predetermined structure and activity, specific recognition and environmental stability, and can play an active role in the fields of enrichment, separation, detection and analysis, and efficient subtraction of PAEs

Method used

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  • A preparation method of dimethyl phthalate molecularly imprinted microspheres
  • A preparation method of dimethyl phthalate molecularly imprinted microspheres
  • A preparation method of dimethyl phthalate molecularly imprinted microspheres

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Embodiment 1

[0035] (1) Take by weighing 1.0g chitosan and be dissolved in 25mL 2% acetic acid solution, let it defoam for 12 hours, add chitosan solution dropwise in sodium hydroxide ethanol mixed solution (10% NaOH and 95% ethanol, the volume ratio is 4: 1), to obtain chitosan microspheres with regular shape and uniform particle size, and place the prepared chitosan microspheres in the mixed solution for aging for 24 hours. Filter to obtain chitosan microspheres (CS), wash 5 times with distilled water, remove excess sodium hydroxide ethanol mixture, then chitosan microspheres are added to 50mL glutaraldehyde solution (mass percentage is 1%) (equivalent In 0.005mol glutaraldehyde), magnetically stirred for 2h. Then repeatedly wash with a large amount of distilled water, to remove residual glutaraldehyde solution, obtain the chitosan microsphere carrier (CS-CHO) after aldehyde group cross-linking;

[0036](2) Add 0.5 g of the cross-linked chitosan microspheres obtained in the above step (...

Embodiment 2

[0038] (1) Weigh 2.0g of chitosan and dissolve 40mL of 2% acetic acid solution, let it defoam for 8 hours, and add the chitosan solution dropwise into the sodium hydroxide ethanol mixture (10% NaOH and 95% ethanol, the volume ratio is 4: 1), to obtain chitosan microspheres with regular shape and uniform particle size, and place the prepared chitosan microspheres in the mixed solution for aging for 20 h. Filter to obtain chitosan microspheres (CS), wash 7 times with distilled water, remove excess sodium hydroxide ethanol solution, chitosan microspheres are added to 50mL glutaraldehyde solution (mass percentage 1%) (equivalent to 0.005mol glutaraldehyde), magnetically stirred for 3 h. Then it was repeatedly washed with a large amount of distilled water to remove the residual glutaraldehyde solution to obtain the chitosan microsphere carrier (CS-CHO) after aldehyde group cross-linking.

[0039] (2) Add 1.0 g of the cross-linked chitosan microspheres obtained in the above step (1...

Embodiment 3

[0041] (1) Take by weighing 1.5g chitosan and be dissolved in 20mL 2% acetic acid solution, let stand for 15 hours to make it defoam, add chitosan solution dropwise in sodium hydroxide ethanol mixed solution (10% NaOH and 95% ethanol, the volume ratio is 4: 1), obtain the chitosan microsphere of regular shape, uniform particle size, put the prepared chitosan microsphere in the mixture and age for 28h, filter to obtain chitosan Microspheres (CS), washed 4 times with distilled water to remove excess sodium hydroxide ethanol solution. Chitosan microspheres were added to 50 mL of glutaraldehyde solution (1% by mass) (equivalent to 0.005 mol of glutaraldehyde), and magnetically stirred for 1 h. Then it was repeatedly washed with a large amount of distilled water to remove the residual glutaraldehyde solution to obtain the chitosan microsphere carrier (CS-CHO) after aldehyde group cross-linking.

[0042] (2) Add 0.75 g of the cross-linked chitosan microspheres obtained in the above...

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Abstract

The invention relates to the field of molecularly imprinted polymers. In order to solve the problem that the adsorptivity of a recognition site is not excellent when dimethyl phthalate molecules are detected by adopting a molecular imprinting technique, the invention provides a preparation method for the dimethyl phthalate molecularly imprinted microspheres. The molecularly imprinted microspheres prepared by the method have structure-activity preordainment, specific recognition and environmental stability and can play a positive role in the field of enrichment and separation, detection and analysis and efficient deduction of phthalic acid ester (PAEs).

Description

technical field [0001] The invention relates to the field of molecularly imprinted polymers, in particular to a preparation method of dimethyl phthalate molecularly imprinted microspheres. Background technique [0002] Phthalates (PAEs) are a class of ubiquitous organic compounds that are mainly used as plasticizers and softeners for plastics in a wide range of applications. Dimethyl phthalate (DMP) is a common PAEs. Because it is difficult for PAEs compounds to be firmly combined with plastics and other products, they are in a free state in plastics and other products. As time goes by, they are easily released from plastics and other products, and PAEs themselves are difficult to quickly decompose into other substances, so they are widely used. Existing in the environment and organisms, studies have shown that a variety of PAEs have three-inducing (mutogenic, teratogenic, carcinogenic) effects, and can produce a variety of biochemical and overall effects that disrupt anima...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/06C08F222/14C08J9/26B01J20/26B01J20/30
Inventor 郭明谭贤娄钧翼孙立苹
Owner ZHEJIANG FORESTRY UNIVERSITY