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Cistanche extract phenylethanol total glycosides flexible nano-liposome freeze-dried powder and preparation method thereof

A Cistanche extract and nano-liposome technology are applied in the fields of pharmaceutical formulas, cosmetic preparations, and dressing preparations, etc., which can solve the problem that liposome particles are easily oxidized, active substances leak, and limit the application of liposomes. and other problems, to achieve the effect of prolonging the action time, good encapsulation rate, and improving the effect of transdermal absorption

Active Publication Date: 2018-05-11
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(5) Good stability: long-term storage of liposome solutions will have many problems, such as leakage of active substances, aggregation of liposome particles, and easy oxidation of phospholipids in a liquid state. Application in Cosmetics

Method used

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  • Cistanche extract phenylethanol total glycosides flexible nano-liposome freeze-dried powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: The flexible nano-liposome freeze-dried powder of phenylethanol total glycosides from Cistanche deserticola extract, raw materials include 1 to 10 parts by weight of total phenylethanol glycosides from Cistanche deserticola extract, 60 to 140 parts of egg Phospholipids, 10 to 90 parts of cholesterol and 10 to 120 parts of surfactants, and the flexible nano-liposome freeze-dried powder of phenylethanol total glycosides extracted from Cistanche are obtained by the following preparation method: the first step, to the required A certain amount of lecithin and cholesterol are added with an organic solvent until the lecithin and cholesterol are completely dissolved in the organic solvent to obtain a solution; in the second step, the solution is evaporated under reduced pressure, and when the solution is evaporated under reduced pressure, a film appears , add the organic mixed solution to the dissolving liquid until the film is dissolved to obtain the oil phase; the ...

Embodiment 2

[0023] Example 2: The flexible nanoliposome freeze-dried powder of phenylethanol total glycosides from Cistanche deserticola extracts, raw materials include 1 or 10 parts by weight of total phenylethanol glycosides from Cistanche deserticola extract, 60 or 140 parts of egg Phospholipids, 10 or 90 parts of cholesterol and 10 or 120 parts of surfactants, Cistanche extract phenylethanol total glycosides flexible nano-liposome freeze-dried powder is obtained by the following preparation method: the first step, to the required A certain amount of lecithin and cholesterol are added with an organic solvent until the lecithin and cholesterol are completely dissolved in the organic solvent to obtain a solution; in the second step, the solution is evaporated under reduced pressure, and when the solution is evaporated under reduced pressure, a film appears , add the organic mixed solution to the dissolving liquid until the film is dissolved to obtain the oil phase; the third step, add the...

Embodiment 3

[0024] Embodiment 3: The flexible nanoliposome freeze-dried powder of phenylethanol total glycosides of Cistanche deserticola extract, raw materials include 6 to 10 parts by weight of total phenylethanol glycosides of Cistanche deserticola extract, 80 to 100 parts of egg Phospholipids, 60 to 90 parts of cholesterol and 80 to 110 parts of surfactants, Cistanche genus extract phenylethanol total glycosides flexible nano-liposome freeze-dried powder are obtained according to the following preparation method: the first step, to the required A certain amount of lecithin and cholesterol are added with an organic solvent until the lecithin and cholesterol are completely dissolved in the organic solvent to obtain a solution; in the second step, the solution is evaporated under reduced pressure, and when the solution is evaporated under reduced pressure, a film appears , add the organic mixed solution to the dissolving liquid until the film is dissolved to obtain the oil phase; the thir...

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Abstract

The invention relates to the technical field of flexible nano-liposome freeze-dried powder and a preparation method thereof, in particular to flexible nano-liposome freeze-dried powder prepared by cistanche tubulosa extract phenylethanoid glycosides and a preparation method thereof. In preparation, the flexible nano-liposome freeze-dried powder prepared by cistanche tubulosa extract phenylethanoid glycosides comprises the raw materials of the cistanche tubulosa extract phenylethanoid glycosides, lecithin, cholesterin and sodium cholate. Cistanche tubulosa extract phenyylethanoid glycosides are prepared into the nano-liposome freeze-dried powder for the first time, the transdermal absorption effect of cistanche tubulosa extract phenylethanoid glycosides is improved, meanwhile, the action time of cistanche tubulosa extract phenylethanoid glycosides is prolonged, and according to the features that the flexible nano-liposome freeze-dried powder prepared by cistanche tubulosa extract phenylethanoid glycosides has good encapsulation efficiency and is small in particle size and good in stability, technical bases are provided for development of cosmetics or related products with cistanche tubulosa extract phenylethanoid glycosides being main components at the later period.

Description

technical field [0001] The invention relates to the technical field of flexible nano-liposome freeze-dried powder and a preparation method thereof, and relates to a flexible nano-liposome freeze-dried powder of phenylethanol total glycosides extracted from the genus Cistanche and a preparation method thereof. Background technique [0002] Cistanche is one of the most distinctive and advantageous medicinal resources in Xinjiang. Many ancient Chinese medicine documents have recorded that Cistanche has the effect of pleasing and beautifying the skin. Studies have shown that the whitening and sunscreen effects of phenylethanol glycosides extracted from Cistanche deserticola are mainly related to the following factors: (1) Inhibition of tyrosinase activity and reduction of melanin formation. Tyrosinase is the rate-limiting enzyme that catalyzes the production of melanin in melanocytes. The total phenylethanol glycosides of Cistanche deserticola can penetrate into the skin, and ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/02A61K8/9789A61Q19/02
CPCA61K8/14A61K8/97A61Q19/02
Inventor 杨建华胡君萍许欢欢居博伟吴姗姗朱丹丹曹丹丹
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY