Esomeprazole magnesium enteric pellet capsule and preparation method thereof
A technology of esomeprazole magnesium enteric-coated pellets and meprazole magnesium enteric-coated pellets, which is applied in the field of enteric-coated pellets and capsules and its preparation, and can solve the problems of poor preparation stability, insufficient oral release, and easy degradation. problems, to achieve good acid resistance, good release effect
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[0043] Examples 1 to 4 Comparative Examples 1 to 2 Esomeprazole magnesium enteric-coated pellet capsules and preparation method thereof
[0044] The formulations of the esomeprazole magnesium enteric-coated pellet capsules of Examples 1 to 4 and Comparative Examples 1 to 2 are as described in Table 1. The particle size distribution diagrams of the active pharmaceutical ingredients in the following Examples 1 to 4 are as follows figure 1 Shown.
[0045] Table 1 Formulas of esomeprazole magnesium enteric-coated pellet capsules in Examples 1 to 4 (unit: g)
[0046]
[0047] See figure 2 Schematic diagram of the basic process of coating. The preparation methods of the pellet capsules of the above Examples 1 to 4 and Comparative Examples 1 to 2 are as follows:
[0048] 1. Preparation of drug-loaded layer pellets
[0049] (1) Preparation of the coating liquid for the drug-loading layer: Weigh the components of the drug-loading layer composition according to the prescription in Table 1, take...
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