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Lansoprazole enteric-coated tablet

A technology of lansoprazole intestines and lansoprazole, which is applied in the field of medicine, can solve problems such as the difference between the onset time and clinical curative effect, increase production costs, and slow down the onset of the drug, and achieve easy operation, good acid resistance, Improve the effect of liver protein synthesis

Inactive Publication Date: 2018-02-16
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the onset time and clinical efficacy of enteric-coated tablets containing lansoprazole on the market at home and abroad vary greatly
In addition, the multi-layer coating technology will delay the rapid release and absorption of the drug in the duodenum, as well as delay the initial inhibitory effect on gastric acid, slow down the onset of the drug, delay the peak time, and increase the process requirements , which increases the production cost

Method used

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  • Lansoprazole enteric-coated tablet
  • Lansoprazole enteric-coated tablet
  • Lansoprazole enteric-coated tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: Take lansoprazole, calcium carbonate, hydroxypropyl methylcellulose phthalate, microcrystalline cellulose, alginic acid by weight, count as 1:8:12:3:0.2, grind into fine Powder, mix lansoprazole, calcium carbonate, and microcrystalline cellulose, use alginic acid as a binder, prepare granules, press into tablets, and coat with hydroxypropylmethylcellulose phthalate, that is, Lansoprazole azole enteric-coated tablets.

Embodiment 2

[0016] Embodiment 2: Take lansoprazole, calcium carbonate, hydroxypropyl methylcellulose phthalate, microcrystalline cellulose, alginic acid by weight, count as 1:15:6:6:0.1, grind into fine Powder, mix lansoprazole, calcium carbonate, and microcrystalline cellulose, use alginic acid as a binder, prepare granules, press into tablets, and coat with hydroxypropylmethylcellulose phthalate, that is, Lansoprazole azole enteric-coated tablets.

Embodiment 3

[0017] Embodiment 3: take by weight lansoprazole, calcium carbonate, hydroxypropyl methylcellulose phthalate, microcrystalline cellulose, alginic acid, count as 1:12:8:5:0.15, grind into fine Powder, mix lansoprazole, calcium carbonate, and microcrystalline cellulose, use alginic acid as a binder, prepare granules, press into tablets, and coat with hydroxypropylmethylcellulose phthalate, that is, Lansoprazole azole enteric-coated tablets.

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PUM

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Abstract

The invention provides a lansoprazole enteric-coated tablet, which is prepared from lansoprazole, a filler, an enteric coating layer, a disintegrating agent and a binding agent. The filer is calcium carbonate; the enteric coating layer is hydroxypropyl methyl cellulose phthalate; the disintegrating agent is microcrystalline cellulose; the binding agent is alginic acid. The invention discloses a preparation method of the lansoprazole enteric-coated tablet and new application of the lansoprazole enteric-coated tablet on improving liver protein synthesis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a lansoprazole enteric-coated tablet. Background technique [0002] Lansoprazole (Lansoprazole) is a benzimidazole derivative with gastric acid secretion inhibitory effect developed by Japanese Takeda Pharmaceutical Company in the late 1980s, and has been proved by clinical experiments that the compound has anti-ulcer activity, controls gastric acid secretion, protects Gastric mucosa, low toxicity and other characteristics, it was first listed in Japan in 1992. The chemical name of lansoprazole is 2-[3-methyl-4-(2,2,2-trifluoroethyl)-2-pyridyl]-methylsulfinyl-1H-benzimidazole, which has The chemical structure shown in the formula (Lansoprazole). [0003] [0004] Lansoprazole enteric-coated preparations generally make lansoprazole into pellets and then enteric-coated, or put lansoprazole into enteric-coated hollow capsules to protect lansoprazole from gastric acid damage. ...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K47/38A61K31/4439A61P1/16
CPCA61K9/2866A61K31/4439
Inventor 赵明亮赵菊兰
Owner NANJING ZHENGLIANG MEDICAL TECH
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