Lansoprazole enteric-coated tablet

A technology of lansoprazole intestines and lansoprazole, which is applied in the field of medicine, can solve problems such as the difference between the onset time and clinical curative effect, increase production costs, and slow down the onset of the drug, and achieve easy operation, good acid resistance, Improve the effect of liver protein synthesis

Inactive Publication Date: 2018-02-16
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the onset time and clinical efficacy of enteric-coated tablets containing lansoprazole on the market at home and abroad vary greatly
In addition, the multi-layer coating technology will delay the rapid release and absor

Method used

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  • Lansoprazole enteric-coated tablet
  • Lansoprazole enteric-coated tablet
  • Lansoprazole enteric-coated tablet

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0015] Example 1: Weigh lansoprazole, calcium carbonate, hydroxypropylmethyl cellulose phthalate, microcrystalline cellulose, and alginic acid according to the weight ratio, which is 1:8:12:3:0.2, and crushed into fine particles. Powder, mix lansoprazole, calcium carbonate, microcrystalline cellulose, use alginic acid as a binder, prepare granules, press them, and coat them with hydroxypropylmethylcellulose phthalate to obtain lansoprazole Azole enteric-coated tablets.

Example Embodiment

[0016] Example 2: Weigh lansoprazole, calcium carbonate, hydroxypropylmethyl cellulose phthalate, microcrystalline cellulose, and alginic acid according to the weight ratio, which is 1:15:6:6:0.1, and crushed into fine particles. Powder, mix lansoprazole, calcium carbonate, microcrystalline cellulose, use alginic acid as a binder, prepare granules, press them, and coat them with hydroxypropylmethylcellulose phthalate to obtain lansoprazole Azole enteric-coated tablets.

Example Embodiment

[0017] Example 3: Weigh lansoprazole, calcium carbonate, hydroxypropylmethyl cellulose phthalate, microcrystalline cellulose, and alginic acid according to the weight ratio, and calculate it as 1:12:8:5:0.15, and pulverize into fine particles. Powder, mix lansoprazole, calcium carbonate and microcrystalline cellulose, use alginic acid as a binder to prepare granules, press tablets, and coat with hydroxypropylmethylcellulose phthalate to obtain lansoprazole Azole enteric-coated tablets.

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PUM

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Abstract

The invention provides a lansoprazole enteric-coated tablet, which is prepared from lansoprazole, a filler, an enteric coating layer, a disintegrating agent and a binding agent. The filer is calcium carbonate; the enteric coating layer is hydroxypropyl methyl cellulose phthalate; the disintegrating agent is microcrystalline cellulose; the binding agent is alginic acid. The invention discloses a preparation method of the lansoprazole enteric-coated tablet and new application of the lansoprazole enteric-coated tablet on improving liver protein synthesis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a lansoprazole enteric-coated tablet. Background technique [0002] Lansoprazole (Lansoprazole) is a benzimidazole derivative with gastric acid secretion inhibitory effect developed by Japanese Takeda Pharmaceutical Company in the late 1980s, and has been proved by clinical experiments that the compound has anti-ulcer activity, controls gastric acid secretion, protects Gastric mucosa, low toxicity and other characteristics, it was first listed in Japan in 1992. The chemical name of lansoprazole is 2-[3-methyl-4-(2,2,2-trifluoroethyl)-2-pyridyl]-methylsulfinyl-1H-benzimidazole, which has The chemical structure shown in the formula (Lansoprazole). [0003] [0004] Lansoprazole enteric-coated preparations generally make lansoprazole into pellets and then enteric-coated, or put lansoprazole into enteric-coated hollow capsules to protect lansoprazole from gastric acid damage. ...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K47/38A61K31/4439A61P1/16
CPCA61K9/2866A61K31/4439
Inventor 赵明亮赵菊兰
Owner NANJING ZHENGLIANG MEDICAL TECH
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