Medical injectable bonding gel and preparation method thereof

A gel and injection device technology, applied in the fields of application, medical science, surgical adhesives, etc., can solve the problems of unsuitable mass production of oxidized dextran, high consumption, and long dialysis time

Active Publication Date: 2015-12-09
IMEIK TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in actual operation, the dialysis time is too long and a large amount of

Method used

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  • Medical injectable bonding gel and preparation method thereof
  • Medical injectable bonding gel and preparation method thereof
  • Medical injectable bonding gel and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0047] Example 1: Preparation of modified dextran (molecular weight 1200KDa, oxidation degree 20%)

[0048] Weigh 250g of dextran powder (containing 1.54 mol glucose unit, molecular weight 1200KDa), and dissolve it in 2.5L of deionized water to obtain an aqueous solution of dextran. Under dark conditions, weigh 66g of sodium periodate (0.31mol, 20% of the total glucose unit) and dissolve it in 0.2L of deionized water. Mix the sodium periodate solution and the dextran solution, control the temperature of the water bath at 30°C, and continue the reaction for 3 hours in a dark environment. After the reaction, the reaction solution is passed through an anion exchange column containing 7L strong base anion resin (material is strong base polystyrene gel resin, Tianjin Nankai Hecheng Technology Co., Ltd., model 001×7), and then through the same Volume of cation exchange column (material is strong acid type polystyrene gel resin, Tianjin Nankai Hecheng Technology Co., Ltd., model 201×7)...

Example Embodiment

[0049] Example 2: Preparation of modified dextran (molecular weight 800KDa, oxidation degree 100%)

[0050] Weigh 250g of dextran powder (containing 1.54 mol glucose unit and 800KDa molecular weight), and dissolve it in 2.0L of deionized water to obtain an aqueous solution of dextran. Under dark conditions, weigh 395g of sodium periodate (1.85mol, 120% of the total glucose unit) and dissolve it in 1L of deionized water. Mix the sodium periodate solution and the dextran solution, control the temperature of the water bath at 30°C, and continue the reaction for 3 hours in a dark environment. Add 40mL of glycerol (0.55mol) to quench the unreacted sodium periodate. After the reaction is over, the reaction solution is passed through an anion exchange column containing 7L strong base anion resin (same as the exchange column described above), and then through the same volume of cation exchange column (same as the exchange column described above), and the flow rate is controlled. At 50m...

Example Embodiment

[0051] Example 3: Preparation of medical injectable adhesive gel (modified dextran molecular weight 1000KDa, oxidation degree 50%)

[0052] Weigh 250g of dextran powder (containing 1.54 mol glucose unit, molecular weight 1000KDa), and dissolve it in 2.0L of deionized water to obtain an aqueous solution of dextran. Under dark conditions, weigh 165g of sodium periodate (0.77mol, accounting for 50% of the total glucose unit) and dissolve it in 0.8L of deionized water. Mix the sodium periodate solution and the dextran solution, control the temperature of the water bath at 30°C, and continue the reaction for 3 hours in a dark environment. After the reaction is over, the reaction solution is passed through an anion exchange column containing 7L strong base anion resin, and then through a cation exchange column of the same volume. The flow rate is controlled at 50 mL·min. -1 . The content of sodium iodate in the effluent is less than 1mg·L -1 After that, the effluent was placed in a re...

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Abstract

The invention relates to medical injectable bonding gel and a preparation method thereof. According to the preparation method, the gel is formed in situ by mixing a properly modified dextran water solution and a multi-amino compound crosslinking agent solution. A mixed solution of the bonding gel is in a liquid state at the initial stage, seams in the wound surface can be quickly filled with the mixed solution along with a chemical crosslinking reaction, and the mixed solution is gelatinized, so that the gel which is immobile and has certain bonding strength can be formed finally. The gel causes no oppression on nerves, is free of influence of body position, and can bear pressure between tissues; the degradation time is relatively long, so that the wound part can completely keep durable bonding strength until the part is completely healed; the gel is nontoxic and non-irritant to in-vivo tissues, and thus can be degraded or absorbed in vivo finally; gel can be widely applied to postoperative bonding and sealing between body tissues as well as between implant materials and body tissues in departments of neurosurgery, brain surgery, general surgery, orthopedics, cardiothoracic surgery, urinary surgery, gynaecology and obstetrics, and the like.

Description

technical field [0001] The invention relates to a medical injectable adhesive gel and a preparation method thereof. After mixing the suitably modified dextran aqueous solution and the polyamino compound cross-linking agent solution, the medical injectable adhesive gel can be formed in situ. The mixed solution of the adhesive gel is in a liquid state at the beginning, and quickly fills the gaps in the wound surface. With the progress of the chemical cross-linking reaction, the mixed solution gels, and finally forms a gel that cannot flow and has a certain adhesive strength. . The medical injectable adhesive gel will not cause compression to the nerves, is not affected by the position of the body and can withstand the pressure between the tissues. It has a long degradation time and can completely maintain long-term adhesive strength at the wound site until the site is completely healed , is non-toxic and non-irritating to tissues in the body, and can eventually be completely d...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/10A61L24/00A61L24/04G01N11/00C08B37/02
Inventor 简军李睿智李东风
Owner IMEIK TECH DEV CO LTD
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