Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medical injectable bonding gel and preparation method thereof

A gel and injection device technology, applied in the fields of application, medical science, surgical adhesives, etc., can solve the problems of unsuitable mass production of oxidized dextran, high consumption, and long dialysis time

Active Publication Date: 2015-12-09
IMEIK TECH DEV CO LTD
View PDF7 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in actual operation, the dialysis time is too long and a large amount of water is consumed, which is not suitable for mass production of oxidized dextran

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical injectable bonding gel and preparation method thereof
  • Medical injectable bonding gel and preparation method thereof
  • Medical injectable bonding gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Preparation of modified dextran (molecular weight 1200KDa, oxidation degree 20%)

[0048] Weigh 250 g of dextran powder (containing 1.54 mol of glucose units, molecular weight of 1200 KDa), and dissolve it in 2.5 L of deionized water to obtain an aqueous solution of dextran. Under dark conditions, weigh 66 g of sodium periodate (0.31 mol, accounting for 20% of the total glucose units), and dissolve it in 0.2 L of deionized water. The sodium periodate solution was mixed with the dextran solution, the temperature of the water bath was controlled to be 30° C., and the reaction was continued for 3 h in a dark environment. After the reaction, the reaction solution was first passed through an anion exchange column containing 7L strong base anion resin (the material is strong base polystyrene gel resin, Tianjin Nankai Hecheng Technology Co., Ltd., model 001×7), and then passed through the same Volumetric cation exchange column (material is strong acid polystyrene g...

Embodiment 2

[0049] Example 2: Preparation of modified dextran (molecular weight 800KDa, degree of oxidation 100%)

[0050] Weigh 250 g of dextran powder (containing 1.54 mol of glucose units, molecular weight 800 KDa), and dissolve it in 2.0 L of deionized water to obtain an aqueous solution of dextran. Under dark conditions, weigh 395 g of sodium periodate (1.85 mol, accounting for 120% of the total glucose units), and dissolve it in 1 L of deionized water. The sodium periodate solution was mixed with the dextran solution, the temperature of the water bath was controlled to be 30° C., and the reaction was continued for 3 h in a dark environment. Add 40 mL (0.55 mol) of glycerol to quench unreacted sodium periodate. After the reaction is over, pass the reaction solution through an anion exchange column containing 7L strong base anion resin (the same exchange column as described above), and then pass through a cation exchange column of the same volume (same as the exchange column describe...

Embodiment 3

[0051] Example 3: Preparation of medical injectable adhesive gel (modified dextran molecular weight 1000KDa, oxidation degree 50%)

[0052] Weigh 250 g of dextran powder (containing 1.54 mol of glucose units, molecular weight of 1000 KDa), and dissolve it in 2.0 L of deionized water to obtain an aqueous solution of dextran. Under dark conditions, weigh 165 g of sodium periodate (0.77 mol, accounting for 50% of the total glucose units), and dissolve it in 0.8 L of deionized water. The sodium periodate solution was mixed with the dextran solution, the temperature of the water bath was controlled to be 30° C., and the reaction was continued for 3 h in a dark environment. After the reaction, the reaction solution was first passed through an anion exchange column containing 7L strong base anion resin, and then passed through a cation exchange column with the same volume, and the flow rate was controlled at 50mL min -1 . Detect that the sodium iodate content in the effluent is les...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Molecular weightaaaaaaaaaa
Molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention relates to medical injectable bonding gel and a preparation method thereof. According to the preparation method, the gel is formed in situ by mixing a properly modified dextran water solution and a multi-amino compound crosslinking agent solution. A mixed solution of the bonding gel is in a liquid state at the initial stage, seams in the wound surface can be quickly filled with the mixed solution along with a chemical crosslinking reaction, and the mixed solution is gelatinized, so that the gel which is immobile and has certain bonding strength can be formed finally. The gel causes no oppression on nerves, is free of influence of body position, and can bear pressure between tissues; the degradation time is relatively long, so that the wound part can completely keep durable bonding strength until the part is completely healed; the gel is nontoxic and non-irritant to in-vivo tissues, and thus can be degraded or absorbed in vivo finally; gel can be widely applied to postoperative bonding and sealing between body tissues as well as between implant materials and body tissues in departments of neurosurgery, brain surgery, general surgery, orthopedics, cardiothoracic surgery, urinary surgery, gynaecology and obstetrics, and the like.

Description

technical field [0001] The invention relates to a medical injectable adhesive gel and a preparation method thereof. After mixing the suitably modified dextran aqueous solution and the polyamino compound cross-linking agent solution, the medical injectable adhesive gel can be formed in situ. The mixed solution of the adhesive gel is in a liquid state at the beginning, and quickly fills the gaps in the wound surface. With the progress of the chemical cross-linking reaction, the mixed solution gels, and finally forms a gel that cannot flow and has a certain adhesive strength. . The medical injectable adhesive gel will not cause compression to the nerves, is not affected by the position of the body and can withstand the pressure between the tissues. It has a long degradation time and can completely maintain long-term adhesive strength at the wound site until the site is completely healed , is non-toxic and non-irritating to tissues in the body, and can eventually be completely d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L24/08A61L24/10A61L24/00A61L24/04G01N11/00C08B37/02
Inventor 简军李睿智李东风
Owner IMEIK TECH DEV CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com