Scutellaria baicalensis extract preparation method

A technology of Scutellaria baicalensis extract and Scutellaria baicalensis extract, applied in the field of preparation of Scutellaria baicalensis extract, can solve the problems of low utilization of medicinal materials, complicated operation, large environmental pollution, etc., maximize resource utilization, avoid environmental pollution, and operability strong effect

Active Publication Date: 2015-12-09
SHANXI UNIV +1
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The current Scutellaria baicalensis preparation process includes water decoction, ethanol extraction, acid water extraction, combined with secondary acid precipitation, alcohol precipitation, recrystallization and macroporous resin purification, etc., they have the following deficiencies: 1. The availability of medicinal materials is low: use Alcohol and water extraction, especially acid water extraction of medicinal materials, the active ingredients of medicinal materials cannot be fully dissolved, the extraction rate is low, and it is easy to cause waste of resources; 2. Pollution of the environment: a large amount of acid water is generated during the preparation process and discharged into the environment. Large environmental pollution and poor safety; 3. The steps are complicated, the operation is cumbersome, and the production cycle is long 4. The product loss is large, the product quality is not high, and the content of baicalin in the final product can only reach 85%

Method used

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Examples

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Embodiment 1

[0022] The preparation of embodiment 1 Scutellaria baicalensis extract

[0023] Take the dried root of Scutellaria baicalensis, crush it, pass through a 40-mesh sieve, weigh 10 g of Scutellaria baicalensis powder (3 parallel samples each), adjust the pH of 70% ethanol to 4-5 with hydrochloric acid as the extraction solvent, and extract twice at 80°C under reflux, each time at 1.5 h, the two solvent dosages are 100ml and 80ml respectively, filter, combine the two filtrates, and set the volume to a 250ml volumetric flask to obtain the Scutellaria baicalensis extract, and measure the paste yield and baicalin content.

Embodiment 2

[0024] The preparation of embodiment 2 Scutellaria baicalensis extract

[0025] Take the dried roots of Scutellaria baicalensis, crush them, pass through a 40-mesh sieve, weigh 10 g of Scutellaria baicalensis powder (3 parallel samples each), and extract twice with 70% ethanol with a pH of 3 to 4 at 80°C for 1.5 hours each time, twice with solvent The dosages were 100ml and 80ml respectively, filtered, combined the two filtrates, and settled in a 250ml volumetric flask to obtain the Scutellaria baicalensis extract, and the paste yield and baicalin content were measured.

Embodiment 3

[0036] Example 3 Acid precipitation prepares the crude product of Scutellaria baicalensis extract

[0037] Take the dried root of Scutellaria baicalensis, crush it, pass through a 40-mesh sieve, weigh 10 g of Scutellaria baicalensis powder, and extract it twice with 70% ethanol with a pH of 4 to 5 at 80°C for 1.5 hours each time. Filtrate, combine the two filtrates, and dilute to a 250ml volumetric flask to obtain the Scutellaria baicalensis extract. The Scutellaria baicalensis extract was directly adjusted to pH 1 without concentration (3 parallels), incubated at 80°C for 1 hour, left to stand for 12 hours, and centrifuged to obtain the crude baicalin precipitate, which was washed with water, 50% ethanol, and 95% ethanol in sequence until neutral, and dried The crude product of Scutellaria baicalensis extract was obtained, and the content and yield of baicalin were determined. The acid precipitation solution is recovered under reduced pressure, and the pH value measured afte...

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Abstract

The present invention provides a scutellaria baicalensis extract preparation method, wherein scutellaria baicalensis is adopted as a raw material, weak acid ethanol reflux extraction is performed, and one-step acid precipitation and macroporous resin separation and purification are combined to prepare the scutellaria baicalensis extract. According to the present invention, the weak acid ethanol is used to extract, such that the active ingredients in the herb are subjected to complete dissolution and are utilized to the greatest degree; the extraction solution si directly used for acid precipitation without concentration, the purity of the scutellaria baicalensis in the obtained precipitate is high, and the recovered ethanol solvent is the acid ethanol after the acid precipitation so as to be continuously used for the extraction to form the closed loop, such that the acid-free emission is achieved; the purified product has the high recovery rate and the high purity, and the purity of the scutellaria baicalensis in the final product is more than or equal to 95%; and the operation is simple, the process is safe and easy to operate, the two-step acid adjusting method in the current process is avoided, the environmental pollution is reduced, the repeatability is high, the operability is strong, and the method is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of extraction of traditional Chinese medicines, in particular to a preparation method of an extract of Scutellaria baicalensis. Background technique [0002] Scutellaria baicalensis extract is a light yellow powder obtained by extracting and drying Scutellaria baicalensis Georgi, a plant of the Labiatae family; it has a slight gas and a bitter taste. For damp heat, summer heat, chest tightness and nausea, damp heat and fullness, dysentery, jaundice, cough due to lung heat, high fever and polydipsia, vomiting of blood heat at the nose, carbuncle sores, restless fetal movement. It can be used not only in medicine but also in cosmetics, and it is a good raw material for functional beauty cosmetics. The Pharmacopoeia stipulates that the extract of Scutellaria baicalensis is calculated as a dry product, and baicalin (C 21 h 18 o 11 ) content shall not be less than 85.0%. The structural formula of baicalin is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08
Inventor 周玉枝郑艳红秦雪梅李明花张丽增杜冠华
Owner SHANXI UNIV
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