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Application of forsythia suspensa leaves or ingredients of forsythia suspensa leaves to preparation of weight reducing products

A technology of forsythia leaves and diet food, applied in the application of diet health care products and diet foods, the preparation of diet drugs, the application field of forsythia leaves or its components in the preparation of diet products, and can solve problems such as major side effects and the like

Inactive Publication Date: 2015-12-23
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug is a pancrelipase inhibitor, but it has serious side effects, especially liver damage

Method used

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  • Application of forsythia suspensa leaves or ingredients of forsythia suspensa leaves to preparation of weight reducing products
  • Application of forsythia suspensa leaves or ingredients of forsythia suspensa leaves to preparation of weight reducing products
  • Application of forsythia suspensa leaves or ingredients of forsythia suspensa leaves to preparation of weight reducing products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Detection of enzyme inhibitory activity of unprocessed forsythia leaf water extract

[0030] Pick fresh forsythia leaves, wash to remove leaf surface attachments, dry, pulverize, accurately weigh 100g of powder, the ratio of solid to liquid is 1:10, reflux for 2h, the water extract is concentrated and dried, and tested for inhibition of pancreatic lipase activity, 1500μg / mL inhibition rate can reach 26.5% ( figure 1 ).

Embodiment 2

[0031] Example 2: Detection of enzyme inhibitory activity of unprocessed forsythia leaf absolute ethanol extract

[0032] Pick fresh forsythia leaves, wash to remove leaf surface attachments, dry, pulverize, accurately weigh 100g of powder, the ratio of solid to liquid is 1:10, reflux for 2 hours, concentrate and dry the absolute ethanol extract, and detect the activity of pancreatic lipase inhibition. 1500μg / mL inhibition rate can reach 33.8% ( figure 1 ).

Embodiment 3

[0033] Example 3: Detection of enzyme inhibitory activity of water extract of boiled forsythia leaf processed product

[0034] Pick fresh forsythia leaves, wash to remove leaf surface attachments, boil in water for 5-7 minutes, dry, crush, accurately weigh 100g of powder, the ratio of solid to liquid is 1:10, reflux extraction for 2 hours, the water extract is concentrated and dried, and the enzyme activity is inhibited Detection and animal experiments confirmed that the water extract of the processed forsythia leaf was detected by inhibiting pancreatic lipase activity, and the inhibition rate of 1500 μg / mL could reach 33.2% ( figure 1 ).

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Abstract

The invention discloses application of forsythia suspensa leaves or ingredients of forsythia suspensa leaves to the preparation of weight reducing medicine, weight reducing products and weight reducing food. The forsythia suspensa leaves are fresh forsythia suspensa leaves or dry forsythia suspensa leaves or forsythia suspensa leaf processed products in modes of water soaking, water steaming, water boiling and drying or other water removing modes; the ingredients of the forsythia suspensa leaves are water extracts of the forsythia suspensa leaves, ethanol extracts with different ethanol concentrations of the forsythia suspensa leaves, water extract precipitates of the forsythia suspensa leaves and water precipitation precipitates of different ethanol concentration ethanol extracts of the forsythia suspensa leaves, ingredients, eluted by different ethanol concentrations of macroporous resin, of water extracts of the forsythia suspensa leaves, or ingredients, eluted by different ethanol concentrations of macroporous resin, of ethanol extracts with different ethanol concentrations of the forsythia suspensa leaves. The forsythia suspensa leaves or the ingredients of the forsythia suspensa leaves have the obvious weight reducing effect; the inhibition rate of 1500mug / ml of ethanol extracts of water boiled forsythia suspensa leaf processed products on the pancreatic lipase can reach 39.5 percent; the ingredients IC50, eluted by macroporous resin, of the water boiled forsythia suspensa leaf processed product ethanol extracts can reach 230mu g / mL; the kaempferol-3-O-rutinoside IC50 in the forsythia suspensa leaves or the ingredients of the forsythia suspensa leaves can reach 1.7+ / -0.3mu g / mL.

Description

technical field [0001] The present invention relates to a new application of the plant or its extract, in particular to the application of forsythia leaf or its components in the preparation of weight-loss products, that is, the application in the preparation of weight-loss medicine, weight-loss health care product and weight-loss food. Background technique [0002] The World Health Organization has clearly identified obesity as the world's largest chronic disease and a global epidemic [ReportofaWHOconsultation.2000,894:i-xii,1-253]. More than 1 billion adults and 10% of children in the world are overweight and obese [Haslam DW, et al. Lancet. 2005, 366(9492): 1197-209]. The overweight rate of adults in my country is 22.8%, and the obesity rate is 7.1%. The estimated numbers are 200 million and over 60 million respectively [Edited by Wang Longde. People's Health Publishing House, 2005]. [0003] Excessive obesity can cause 57% of non-insulin-dependent (type II) diabetes; 30...

Claims

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Application Information

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IPC IPC(8): A61K36/634A23L1/29A61P3/04
Inventor 陈廷贵李飞鹤栗亚云张立伟
Owner SHANXI UNIV