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The preparation method of chitosan nanosphere

A technology of chitosan nano and chitosan, which is applied in the direction of nanotechnology, can solve problems such as complicated procedures, and achieve the effect of reducing costs and simple preparation methods

Active Publication Date: 2018-02-27
ANHUI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many synthesis methods of chitosan nanomaterials, but the most commonly used methods are as follows: emulsification cross-linking method, ion gel method, neutralization precipitation method, spray drying method, complex coacervation method and solvent evaporation method, etc. But the current method is more complicated

Method used

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  • The preparation method of chitosan nanosphere
  • The preparation method of chitosan nanosphere
  • The preparation method of chitosan nanosphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Dissolving 100mg chitosan in 40ml deionized water, stirring and mixing;

[0032] (2) add 2ml glacial acetic acid in the solution that step (1) obtains, stir until chitosan solid dissolves completely;

[0033] (3) Add 300 mg of EDTA disodium salt to the mixed solution obtained in step (2), stir and mix;

[0034] (4) Add dehydrated alcohol 14ml dropwise to the mixed solution obtained in step (3), until the solution becomes milky white;

[0035] (5) Transfer the mixed solution obtained in step (4) to a reaction kettle, the reaction temperature is 160°C, and the reaction is performed at a constant temperature for 10 hours;

[0036] (6) Cool the mixed solution obtained in step (5) to room temperature, centrifuge, wash with water, and dry at 60°C.

Embodiment 2

[0038] (1) Dissolving 100mg chitosan in 40ml deionized water, stirring and mixing;

[0039] (2) add 4ml glacial acetic acid in the solution that step (1) obtains, stir until chitosan solid dissolves completely;

[0040] (3) Add 300 mg of EDTA disodium salt to the mixed solution obtained in step (2), stir and mix;

[0041] (4) Add dehydrated alcohol 14ml dropwise to the mixed solution obtained in step (3), until the solution becomes milky white;

[0042] (5) Transfer the mixed solution obtained in step (4) to a reaction kettle, the reaction temperature is 160°C, and the reaction is performed at a constant temperature for 10 hours;

[0043] (6) Cool the mixed solution obtained in step (5) to room temperature, centrifuge, wash with water, and dry at 60°C.

Embodiment 3

[0045] (1) Dissolving 100mg chitosan in 40ml deionized water, stirring and mixing;

[0046] (2) add 6ml glacial acetic acid in the solution that step (1) obtains, stir until chitosan solid dissolves completely;

[0047] (3) Add 300 mg of EDTA disodium salt to the mixed solution obtained in step (2), stir and mix;

[0048] (4) Add dehydrated alcohol 14ml dropwise to the mixed solution obtained in step (3), until the solution becomes milky white;

[0049] (5) Transfer the mixed solution obtained in step (4) to a reaction kettle, the reaction temperature is 160°C, and the reaction is performed at a constant temperature for 10 hours;

[0050] (6) Cool the mixed solution obtained in step (5) to room temperature, centrifuge, wash with water, and dry at 60°C.

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Abstract

The invention discloses a preparation method of chitosan nanospheres, which comprises the following steps: dissolving chitosan in deionized water, stirring and mixing; adding acetic acid to dissolve; adding EDTA disodium salt; adding absolute ethanol; constant temperature React for 7-13 hours; cool to room temperature, centrifuge, wash with water, and dry at 60°C until constant weight. Compared with the prior art, the invention adopts the hydrothermal method to synthesize the chitosan nanosphere material with uniform size, the preparation method is simple, green and pollution-free, the cost is reduced, and the preparation method has very important value in the preparation of nanometer materials.

Description

technical field [0001] The invention belongs to a preparation method of nanomaterials, in particular to a preparation method of chitosan nanospheres. Background technique [0002] Chitosan is an amino polysaccharide (2-amino-2,4-β-glucan) extracted from discarded shrimp and crab shells. It is the only alkaline polysaccharide that exists naturally and has a network structure. Its source Abundant, cheap, easy to prepare, stable chemical properties after modification, heat resistance, acid and alkali resistance and organic reagents, good mechanical properties, good biocompatibility and adaptability, natural degradation, and degradation products It is non-toxic and is a good carrier for immobilizing enzymes. It is widely used in medicine, food, chemical industry, etc. because of its good biocompatibility, natural degradability and non-toxic characteristics. At present, there are many synthesis methods of chitosan nanomaterials, but the most commonly used methods are as follows:...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/12C08J3/03C08L5/08C08B37/08B82Y40/00
Inventor 李茂国李安娜张雪梅王银玲
Owner ANHUI NORMAL UNIV