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Anti-inflammatory analgesic preparation for external application

A technology of anti-inflammatory and analgesic and anti-inflammatory and analgesic drugs, which is applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., can solve the problems of anti-inflammatory and analgesic effects, and achieve transdermal Excellent absorption, alleviating skin irritation, and sufficient curative effect

Inactive Publication Date: 2016-02-17
WUXI CHENGBO SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, when considering the actual skin application, the reality of these topical agents is that the anti-inflammatory and analgesic effects of non-steroidal anti-inflammatory analgesics are not ideal, and further improvement is needed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0044] The preparation method of the external preparation provided by the present invention is not particularly limited. According to the desired dosage form, it can be prepared by fully kneading each component and the required matrix components, etc. for preparing an ordinary external preparation.

[0045] When preparing cataplasms and patches, it can be prepared by spreading the kneaded mixture on release paper, drying the kneaded mixture, bonding it to a soft support, and cutting it into a desired size.

[0046] The external preparations provided by the present invention, for example, when they are ointments, liquid preparations (suspensions, emulsions, lotions, etc.), aerosols, and external powders, are used according to the following usual methods of use: direct application by smearing, etc. Use on affected parts of the skin, or after applying or soaking on a support such as cloth.

[0047] In the case of a cataplasm or a patch, these preparations are directly attached to...

Embodiment 1

[0051] Drug-containing matrices of the formulations shown in Table 1 below were prepared. Specifically, felbinac was dissolved in crotamiton, levobupivacaine was dissolved in propylene glycol, and the two were mixed, and then these dissolved substances and other ingredients shown in Table 1 were mixed until uniform, A drug-containing matrix is ​​obtained. The drug-containing matrix prepared in this way was treated with 1000g / m 2 Spread on non-woven fabric, lined with polypropylene, then cut into 10×14cm 2 , to obtain an external patch.

[0052] Table 1

[0053] Element

[0054] Aluminum Dihydroxyacetate

[0055] Unit: parts by weight

Embodiment 2

[0057] Drug-containing matrices of the formulations shown in Table 2 below were prepared. Specifically, indomethacin was dissolved in crotamiton and levobupivacaine was dissolved in propylene glycol.

[0058] Then, these solubilized substances were mixed with other ingredients shown in Table 2 until uniform to obtain a drug-containing matrix. The drug-containing matrix prepared in this way was treated with 1000g / m 2 Spread on non-woven fabric, lined with polypropylene, then cut into 10×14cm 2 , to obtain an external patch.

[0059] Table 2

[0060] Element

[0061] Polyacrylic acid partially neutralized

[0062] Unit: parts by weight

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PUM

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Abstract

The invention relates to an anti-inflammatory analgesic preparation for external application. The anti-inflammatory analgesic preparation comprises non-steroid anti-inflammatory analgesic drug and levobupivacaine or pharmaceutically acceptable salt which serve as active ingredients, content of the non-steroid anti-inflammatory analgesic drug is equivalent to 0.1-10% of total weight of the preparation, and content of the levobupivacaine or pharmaceutically acceptable salt is equivalent to 0.01-60% of the total weight of the preparation. The anti-inflammatory analgesic preparation can bring anti-inflammatory analgesic effect of the non-steroid anti-inflammatory analgesic drug into effective play to relieve skin irritation at a position where the preparation is applied, and has excellent effect on rheumatoid arthritis or arthronosos deformans and pain with inflammation such as lumbago.

Description

technical field [0001] The present invention relates to anti-inflammatory and analgesic drugs, in detail, relates to non-steroidal anti-inflammatory and analgesic drugs and L-bupivacaine as a local anesthetic or pharmaceutically acceptable salts as active ingredients, An external preparation with significantly improved anti-inflammatory and analgesic effects. Background technique [0002] So far, people have developed a variety of non-steroidal anti-inflammatory analgesics to replace steroidal anti-inflammatory analgesics with many side effects, and gradually used in clinical practice. [0003] Although these non-steroidal anti-inflammatory analgesics exhibit excellent anti-inflammatory and analgesic effects, their side effects of gastrointestinal dysfunction are strong when administered orally. Therefore, studies have been made on transdermal absorption as an administration route that reduces side effects. Preparations, as external preparations containing non-steroidal ant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P29/00A61P17/04A61P25/00A61K31/445
Inventor 李飞
Owner WUXI CHENGBO SCI & TECH DEV
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