3D printing system and technology of coaxial sprayer and enhanced type hollow gel pipe of coaxial sprayer

A coaxial nozzle and 3D printing technology, applied in the field of 3D printing system, can solve the problems of difficult to meet the requirements of biological manufacturing, difficult to ensure the coaxiality of the inner and outer tubes, poor mechanical strength of the hollow circular tube, etc., to achieve simple structure and high performance. Reliable, uniform wall thickness results

Active Publication Date: 2016-02-17
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the material is squeezed in the nozzle and exerts force on the inner tube to deform it, it is difficult to ensure the coaxiality of the inner and outer tubes at the front end of the nozzle.
In particular, when a small inner tube diameter is used, the coaxiality is more difficult to ensure, so the size of the nozzle cannot be small, which restricts the size of the hollow gel tube
[0004] In the existing process of using sodium alginate to manufacture hollow gel tubes, the hollow tubes formed only through the cross-linking reaction of sodium alginate and calcium ions have poor mechanical strength, which is difficult to meet the requirements of biomanufacturing

Method used

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  • 3D printing system and technology of coaxial sprayer and enhanced type hollow gel pipe of coaxial sprayer
  • 3D printing system and technology of coaxial sprayer and enhanced type hollow gel pipe of coaxial sprayer
  • 3D printing system and technology of coaxial sprayer and enhanced type hollow gel pipe of coaxial sprayer

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Select inner tube inner diameter 0.34mm, outer diameter 0.63mm; outer tube inner diameter 1.12mm, outer diameter 1.48mm coaxial nozzle, sodium alginate solution concentration is 2%-4% (w / v), calcium chloride solution concentration is 4% (w / v), the concentration of ferric chloride solution is 0.25% (w / v). The extrusion rate of the sodium alginate solution is 1.5ml / min, that of the calcium chloride solution is 1-3ml / min, and that of the ferric chloride is 4.5ml / min. Reinforced hollow gel tubes with an outer diameter of 800-1200 μm can be printed.

Embodiment 2

[0049] Select inner tube inner diameter 0.24mm, outer diameter 0.45mm; outer tube inner diameter 0.70mm, outer diameter 1.06mm coaxial nozzle, the concentration of sodium alginate solution is 2%-4% (w / v), calcium chloride solution The concentration was 4% (w / v), and the concentration of the ferric chloride solution was 0.25% (w / v). The extrusion rate of the sodium alginate solution is 1.5ml / min, that of the calcium chloride solution is 1-3ml / min, and that of the ferric chloride is 4.5ml / min. Reinforced hollow gel tubes with an outer diameter of 500-800 μm can be printed.

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Abstract

The invention discloses a 3D printing system and technology of a coaxial sprayer and an enhanced type hollow gel pipe of the coaxial sprayer. The 3D printing system comprises a 3D printing platform, two sets of feed devices, the coaxial sprayer, spraying devices and a control system. Furthermore, the coaxial sprayer is composed of an inner pipe, an outer pipe, two feed ports, a sealing gasket and a welding piece. By means of the coaxial sprayer, the coaxiality between the inner pipe and the outer pipe at the front end of the sprayer is better guaranteed through the welding piece, and closing between the inner pipe and the outer pipe is guaranteed through the sealing gasket. According to the printing technology of the enhanced type hollow gel pipe, ferric chloride spraying further reacts with the hollow gel pipe, and the mechanical strength of the hollow gel pipe is improved. The coaxial sprayer and the spraying devices are arranged on the XY printing platform, the control system controls running of the printing platform, the feeding device and the spraying devices, and in combination with the printing technology of the enhanced type hollow gel pipe, printing of the enhanced type hollow gel pipe is jointly combined.

Description

Technical field: [0001] The invention belongs to the intersecting field of mechanical automation, biotechnology and tissue engineering, and specifically relates to a 3D printing system and process of a coaxial nozzle and its enhanced hollow gel tube. Background technique: [0002] Due to the lack of effective vascular network to transport nutrients and metabolic wastes, artificial tissues are difficult to produce large-scale and complex structures. Printing hollow gel tubes during tissue printing can effectively help transport nutrients and waste, acting as a vascular network. The printing system based on coaxial nozzles can print hollow gel tubes, but there are the following problems: [0003] Existing coaxial nozzles utilize the upper ends or middle parts of inner and outer pipes to ensure coaxiality. When the material is squeezed in the nozzle and exerts force on the inner tube to deform it, it is difficult to ensure the coaxiality of the inner and outer tubes at the fr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C67/00B33Y30/00
Inventor 连芩毛伟李晓李涤尘贾书海
Owner XI AN JIAOTONG UNIV
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