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A device for measuring breath nitric oxide and carbon monoxide concentrations

A carbon monoxide and nitric oxide technology, applied in the field of human exhaled gas analysis, can solve problems such as difficulties in real-time measurement of eNO or eCO concentration, slow response time, etc.

Active Publication Date: 2017-09-15
SUNVOU MEDICAL ELECTRONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 3) The response time of other existing detection methods (such as electrochemical sensors) is slow, and the response time to reach 90% is generally greater than 10 seconds. It is difficult to measure the eNO or eCO concentration in real time during the exhalation process

Method used

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  • A device for measuring breath nitric oxide and carbon monoxide concentrations
  • A device for measuring breath nitric oxide and carbon monoxide concentrations
  • A device for measuring breath nitric oxide and carbon monoxide concentrations

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Experimental program
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specific Embodiment approach 1

[0027] The device of the present invention is composed of a sampling module (100) and an analysis module (200). The sampling module is composed of a flow regulator (101), a shut-off valve (405), and a sampling pump (601) connected in series, wherein the flow regulator (101) Connected to flow / pressure sensor (201) and CO 2 The sensor (202), between the flow regulator (201) and the sampling pump (601), is connected in parallel with the air chamber one (301), the solenoid valve one (401), the solenoid valve six (406) and the air chamber connected to the air chamber one. Chamber two (302), solenoid valve two (402) and solenoid valve seven (407) connected front and back to gas chamber one; the analysis module consists of gas chamber one (301), solenoid valve one (401) or gas chamber two (302), solenoid valve two (402), three-way valve one (403), analysis pump (602), three-way valve two (404), gas humidity regulator (701), NO sensor (801), solenoid valve six (406) or solenoid valve...

specific Embodiment approach 2

[0039] Another device for measuring breath nitric oxide and carbon monoxide concentrations is composed of a sampling module (100) and an analysis module (200). The sampling module consists of a flow regulator (101), a shut-off valve (401), an air chamber ( 301), the sampling pump (601) is connected in series, and the flow / pressure sensor (201) and CO are connected to the flow regulator (101). 2 The sensor (202), the cut-off valve (401) is located on the air branch between the flow regulator and the gas chamber (301); the analysis module is sequentially composed of the gas chamber (301), the gas humidity regulator (701), the NO sensor (801), CO sensor (802), analysis pump (602), CO filter (502), and NO filter (501) constitute a circulating gas circuit.

[0040] When the subject begins to exhale, open the flow regulator (101) and the cut-off valve (405), and perform feedback adjustment according to the preset flow rate. At this time, the exhalation is directly discharged into th...

specific Embodiment approach 3

[0041] Another device for measuring breath nitric oxide and carbon monoxide concentrations is composed of a sampling module (100) and an analysis module (200). The sampling module consists of a flow regulator (101), a shut-off valve (405), a sampling pump ( 601) in series, where the flow regulator (101) is connected with a flow / pressure sensor (201) and CO 2 The sensor (202), the cut-off valve (405) is located on the branch air path between the flow regulator and the air chamber, and the air chamber one (301) and the Solenoid valve 1 (401), solenoid valve 6 (406) and gas chamber 2 (302) connected back and forth to gas chamber 1, solenoid valve 2 (402) and solenoid valve 7 (407) connected to gas chamber 1 back and forth; the analysis The module consists of gas chamber one (301), solenoid valve one (401) or gas chamber two (302), solenoid valve two (402), three-way valve one (403), analysis pump (602), three-way valve two ( 404), gas humidity regulator (701), NO sensor (801), s...

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Abstract

A device for measuring the concentration of exhaled nitric oxide and carbon monoxide, which is composed of a sampling and analysis module. The sampling module is composed of a flow regulator, a stop valve, and a sampling pump connected in series. The flow regulator is connected to a flow / pressure sensor and a CO2 sensor. Gas chamber 1 connected in parallel between the pressure regulator and the sampling pump, solenoid valve 1, solenoid valve 6 and gas chamber 2 connected to gas chamber 1, solenoid valve 2 and solenoid valve 7 connected to gas chamber 1 in front and back; the analysis module consists of gas chambers 1. Solenoid valve 1 or air chamber 2, solenoid valve 2, three-way valve 1, analytical pump, three-way valve 2, gas humidity regulator, NO sensor, solenoid valve 6 or solenoid valve 7 constitute a circulating gas circuit; three-way valve One normally open terminal is connected to the front end of gas chamber 1 or gas chamber 2 and the analysis pump, and the switching channel is connected to the front end of air chamber 1 or air chamber 2, NO filter and analysis pump; the two normally open terminals of the three-way valve are connected to the analysis pump and gas humidity Regulator, NO sensor, switching channel termination analysis pump and CO sensor, CO filter.

Description

technical field [0001] The invention relates to the field of human exhaled gas analysis. Background technique [0002] The measurement of the composition and concentration of the human body's exhaled gas can assist doctors in diagnosing patients' diseases, monitoring disease states, and observing treatment effects. [0003] Exhaled nitric oxide (eNO) is used for the diagnosis and monitoring of respiratory system inflammation, and exhaled carbon monoxide (eCO) is used for the diagnosis and monitoring of respiratory and circulatory system diseases. This is because the endogenous gas signal molecules NO and CO respectively Produced by the oxidative deamination of arginine in cortical cells and the decomposition of heme, infection, allergy, trauma and other inflammatory factors can cause NO by increasing the expression of inducible NO synthase (iNOS) and heme oxygenase (HO1). Significantly increased with CO concentration and can be quantified by exhaled breath analysis. Pulmon...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/48G01N1/24
Inventor 曹青韩杰
Owner SUNVOU MEDICAL ELECTRONICS