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Method for preparing stainless steel with antibacterial and anti-cancer properties by means of rhodium complex

A rhodium complex and stainless steel technology, applied in the field of stainless steel, can solve the problems of poor water solubility, patient danger, solvent residue, etc., and achieve the effect of molecular stability

Active Publication Date: 2016-03-16
重庆巨源不锈钢制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some rhodium complexes have poor water solubility. If the rhodium complexes are directly introduced into the surface of stainless steel, more organic solvents need to be used, which will pollute the environment, and there may be solvent residues on the stainless steel, which will cause danger to patients.

Method used

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  • Method for preparing stainless steel with antibacterial and anti-cancer properties by means of rhodium complex
  • Method for preparing stainless steel with antibacterial and anti-cancer properties by means of rhodium complex
  • Method for preparing stainless steel with antibacterial and anti-cancer properties by means of rhodium complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] This scheme utilizes rhodium complex to prepare the method for the stainless steel with antibacterial and anticancer performance, comprises the following steps:

[0026] 1) Dissolve 4 parts by weight of m-carboxybenzaldehyde in 11 parts by weight of toluene, add 12 parts by weight of 1-(9-anthracenyl)ethanol and 1 part by weight of sulfuric acid with a concentration of 98%, and heat to 110° C. and stir and reflux for 2 hours , then the filtrate was spin-dried, added 6 parts by weight of ethyl acetate for extraction, repeated the extraction process of ethyl acetate 4 times, combined the ethyl acetate layer solution, then added 11 parts by weight of anhydrous potassium carbonate and spin-dried to obtain a compound having the formula (1 ), i.e. m-anthracenoxybenzaldehyde;

[0027]

[0028] 2) Dissolve 5 parts by weight of m-anthroxyylbenzaldehyde in 12 parts by weight of absolute ethanol, add 3 parts by weight of thiosemicarbazide, stir under reflux at 65°C, react for 6...

Embodiment 2

[0036] This scheme utilizes rhodium complex to prepare the method for the stainless steel with antibacterial and anticancer performance, comprises the following steps:

[0037] 1) Dissolve 3 parts by weight of m-carboxybenzaldehyde in 10 parts by weight of toluene, add 10 parts by weight of 1-(9-anthracenyl)ethanol and 0.5 parts by weight of sulfuric acid with a concentration of 98%, and heat to 100° C. and stir and reflux for 1 h , then the filtrate is spin-dried, adding 5 parts by weight of ethyl acetate for extraction, repeating the extraction process of ethyl acetate 3 times, combining the ethyl acetate layer solution, then adding 10 parts by weight of anhydrous potassium carbonate and spinning-drying to obtain a compound having the formula (1 ), i.e. m-anthracenoxybenzaldehyde;

[0038]

[0039] 2) Dissolve 4 parts by weight of m-anthroxyylbenzaldehyde in 10 parts by weight of absolute ethanol, add 1 part by weight of thiosemicarbazide, stir under reflux at 60°C, and r...

Embodiment 3

[0047] This scheme utilizes rhodium complex to prepare the method for the stainless steel with antibacterial and anticancer performance, comprises the following steps:

[0048]1) Dissolve 5 parts by weight of m-carboxybenzaldehyde in 15 parts by weight of toluene, add 15 parts by weight of 1-(9-anthracenyl)ethanol and 1.5 parts by weight of sulfuric acid with a concentration of 98%, and heat to 120° C. and stir and reflux for 3 hours , then the filtrate is spin-dried, adding 10 parts by weight of ethyl acetate for extraction, repeating the extraction process of ethyl acetate 5 times, merging the ethyl acetate layer solution, then adding 15 parts by weight of anhydrous potassium carbonate and spinning-drying to obtain a compound having the formula (1 ), i.e. m-anthracenoxybenzaldehyde;

[0049]

[0050] 2) Dissolve 10 parts by weight of m-anthracenoxyacylbenzaldehyde in 20 parts by weight of absolute ethanol, add 5 parts by weight of thiosemicarbazide, reflux and stir at 70°...

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Abstract

The invention discloses a method for preparing stainless steel with antibacterial and anti-cancer properties by means of a rhodium complex. The method comprises the following steps that 1, the rhodium complex is prepared; 2, 0.1-0.6 part by weight of cyclodextrin is dissolved in 3.5-20 parts by weight of water, even stirring is conducted, 0.5-1.5 parts by weight of stainless steel is added, and soaking is conducted for 20-60 min; 3, 0.2-1.2 parts by weight of rhodium complex is added, ultrasonication is conducted for 30-60 min at 15-30 kHz; 4, the stainless steel is taken out and dried. According to the method for preparing the stainless steel with the antibacterial and anti-cancer properties by means of the rhodium complex, by means of the action of the cyclodextrin and the rhodium complex on the stainless steel, the stainless steel has good antibacterial and anti-cancer properties, the surface of the stainless steel facilitates growth of bone cells, the morbidity of complications caused by the stainless steel in an osseointegration operation is decreased, and a safer and more reliable material is provided for the osseointegration operation.

Description

technical field [0001] The invention relates to the technical field of materials for osseointegration surgery, more specifically a method for preparing stainless steel with antibacterial and anticancer properties by using rhodium complexes. Background technique [0002] γ-cyclodextrin is a kind of macrocyclic compound formed by connecting 8 D-glucopyranose units end-to-end through α-1,4 glycosidic bonds. Inside the molecule is a "V"-shaped hydrophobic cavity, showing a unique molecular recognition ability. As a commonly used material in osseointegration surgery, stainless steel is widely used clinically. However, a serious problem is the associated bacterial infection problem, which leads to the failure of a large number of transplant operations. Recently, researchers have focused on improving the antibacterial and other capabilities of stainless steel. How to obtain stainless steel materials with better properties has become a research direction with great scientific and...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/20A61L27/54C23C22/05
CPCA61L27/047A61L27/20A61L27/54A61L2300/224A61L2300/404A61L2300/416C23C22/05C08L5/16
Inventor 李培源苏炜霍丽妮陈睿
Owner 重庆巨源不锈钢制品有限公司
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