Astragalus extract and preparation method thereof and application

An astragalus extract and technology of astragalus, applied in the field of traditional Chinese medicine, can solve the problems of poor stability of injection, easy precipitation and the like, achieve the effects of maintaining stability, overcoming easy precipitation and improving drug efficacy

Active Publication Date: 2016-03-23
广东艾希德药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Currently commercially available Astragalus injections are generally prepared by water extraction and alcohol precipitation. The active ingredient in the injection is Astragalus saponin, which does not contain astragalus polysaccharide or has very little content. Astragalus polysaccharide is also an active

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055]Take astragalus decoction pieces and crush them, add water equivalent to 10 times the volume of Astragalus crude drug, soak for 8 hours, ultrasonically extract at 50°C for 30 minutes, and the ultrasonic frequency is 40kHz; filter, repeat twice, combine the filtrates, and concentrate under reduced pressure to 2g / ml. Add ethanol to precipitate to remove impurities, and divide it into three treatments. For the first time, add ethanol to make the alcohol content reach 50% by volume, place it in cold storage for 15 hours, filter, discard the filter residue, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell; Add ethanol to the filtrate to make the alcohol content 65%, keep it in cold storage for 24 hours, filter, discard the filter residue, and recover the ethanol from the filtrate until it has no alcohol smell; add ethanol to the filtrate for the third time to make the alcohol content reach 90%, and put it in cold storage for 24 hour...

Embodiment 2

[0059] Take astragalus decoction pieces and crush them, add water equivalent to 12 times the volume of the crude drug of Astragalus, soak for 10 hours, ultrasonically extract at 65°C for 35 minutes, and the ultrasonic frequency is 40kHz; filter, repeat 3 times, combine the filtrates, and concentrate under reduced pressure to 2.5g / ml; Add ethanol to precipitate to remove impurities, and divide it into three treatments. For the first time, add ethanol to make the alcohol content reach 52%, put it in cold storage for 18 hours, filter, discard the filter residue, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell; Ethanol to make the alcohol content to 70%, refrigerated for 36 hours, filter, discard the filter residue, and recover ethanol from the filtrate under reduced pressure until it has no alcohol smell; add ethanol to the filtrate for the third time to make the alcohol content reach 95%, refrigerated for 36 hours, filter, The filter...

Embodiment 3

[0063] Take astragalus decoction pieces and crush them, add water equivalent to 15 times the volume of Astragalus crude drug, soak for 12 hours, and ultrasonically extract at 70°C for 40 minutes at a frequency of 40kHz; filter, repeat 3 times, combine the filtrates, and concentrate under reduced pressure to 3g / ml; add Ethanol precipitation to remove impurities, divided into three treatments, adding ethanol for the first time to make the alcohol content reach 55%, refrigerating for 20 hours, filtering, discarding the filter residue, and recovering the ethanol from the filtrate under reduced pressure until it has no alcohol smell; adding ethanol to the filtrate for the second time Make the alcohol content to 75%, refrigerate for 48 hours, filter, discard the filter residue, and recover ethanol from the filtrate under reduced pressure until there is no alcohol smell; add ethanol to the filtrate for the third time to make the alcohol content reach 95%, refrigerate for 48 hours, filt...

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PUM

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Abstract

The invention discloses an astragalus extract and a preparation method thereof and application. Astragalus is smashed, water is added to soak the astragalus, ultrasonic extraction and filtration are performed, and filtrate is taken; the filtrate is concentrated, ethanol is added to perform extraction three times, and the ethanol extraction concentrations are sequentially 50-55%, 65-75% and 90% or above. The filtrate filtered through ethanol extraction for the third time and filter residue are treated respectively, the filtrate undergoes impurity removal, and astragaloside extracting solution is obtained; the filter residue undergoes impurity removal to obtain astragalus polysaccharide extracting liquid; and the astragaloside extracting solution and the astragalus polysaccharide extracting liquid are combined to obtain the astragalus extract. The astragalus extract retains active ingredients of saponin and polysaccharide in astragalus and can be directly used for preparing medicines for treating myocarditis or is combined with other medicines to prepare the medicines for treating myocarditis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to an extract of Astragalus membranaceus and its preparation method and application. Background technique [0002] The traditional Chinese medicine Astragalus has the functions of anti-virus, regulating immunity and protecting the myocardium. It is a commonly used medicine in traditional Chinese medicine. It has no toxic and side effects on the human body, has sufficient sources, and has the basis for treating viral diseases. It is often used clinically to treat viral myocarditis. It can antagonize Virus-infected cardiomyocytes activate L-type calcium channels, inhibit inward sodium-calcium exchange currents, improve part of cardiac electrical activity, and scavenge oxygen free radicals. [0003] Currently commercially available Astragalus injection is generally prepared by water extraction and alcohol precipitation. The active ingredient in the injection is A...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P9/00A61K31/185
CPCA61K9/0019A61K9/08A61K31/185A61K36/481A61K2236/331A61K2236/53A61K2300/00
Inventor 罗锦达罗清
Owner 广东艾希德药业有限公司
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