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Yuanhuzhitong granule and preparation method thereof

A Yuanhu analgesic and granule technology, which is applied in the direction of non-central analgesics, pharmaceutical formulas, medical preparations with non-active ingredients, etc., can solve problems such as poor stability and slow drug onset

Active Publication Date: 2020-06-30
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Yuanhu Zhitong Granules have been included in the Chinese Pharmacopoeia 2015 Edition, but it is directly used as a medicine with all the fine powder of Angelica dahurica, and the drug has a slow onset of action, and the excipient is only sucrose, which leads to poor stability

Method used

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  • Yuanhuzhitong granule and preparation method thereof
  • Yuanhuzhitong granule and preparation method thereof
  • Yuanhuzhitong granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Preparation of Yuanhu Zhitong Granules

[0015] Take 200g of Angelica dahurica and grind it into fine powder, pass through a 100-mesh sieve; crush 1800g of Angelica dahurica and 4000g of vinegar corydalis and sieve into coarse powder, soak with 6 times the amount of 60% ethanol for 14 hours, heat and reflux for 3 hours, and collect the extract; then Add 8 times the amount of 70% ethanol and heat to reflux for 3 hours, collect the extract, combine the two extracts, filter, and concentrate the filtrate to obtain a thick paste; then add the prepared fine powder of Angelica dahurica, mix well, dry in vacuum, and pulverize Pass through a 80-mesh sieve; add 9g of ethyl cellulose, 13g of mannitol and 18g of sucrose to the dried medicinal powder; use 70% ethanol as a soft material, granulate with a 16-mesh sieve, and dry and fill it (5g per bag).

Embodiment 2

[0016] Example 2 Investigation of the performance of Yuanhu Zhitong Granules

[0017] (1) Measurement of angle of repose

[0018] The fixed funnel method was used to measure the angle of repose. Three funnels were connected in series and fixed at a height of 1 cm on the horizontal coordinate paper, and the Chinese medicine particles were poured into the top funnel along the funnel wall until the tip of the cone of particles formed on the coordinate paper touched the funnel. The diameter of the cone bottom is measured from the coordinate paper, and the angle of repose is calculated. The specific results are as follows:

[0019]

Embodiment 3

[0027] Example 3 Investigation on the Stability of Yuanhuzhitong Granules

[0028] The stability of the relevant granules was investigated in accordance with the guidelines on stability in the fourth part of the Chinese Pharmacopoeia 2015 edition, and the stability of the drug was investigated at 25°C for 36 months, at 45°C and at a relative humidity of 75% for 60 days. According to the Chinese Pharmacopoeia 2015 edition one about the quality inspection method of Yuanhu Zhitong Granules, the content of imperatorin and tetrahydropalmatine in the granules was determined by HPLC method.

[0029] Content of active ingredients in granules after storage at 25°C for 36 months

[0030]

[0031] Stored at 45°C and 75% relative humidity for 60 days

[0032]

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Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a rhizoma corydalis pain-relieving particle and a preparation method thereof. The rhizoma corydalis pain-relieving particle is prepared from the following herbs and auxiliary materials in parts by weight: 300-600 parts of rhizoma corydalis processed with vinegar, 100-300 parts of angelica dahurica, 5-20 parts of ethyl cellulose, 5-20 parts of mannitol and 10-30 parts of cane sugar.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to Yuanhuzhitong granules and a preparation method thereof. Background technique [0002] Pain is a protective reaction produced by the body after being subjected to noxious stimuli, often accompanied by emotional activities such as fear and nervousness. In addition to feeling pain and emotional uneasiness, pain can also lead to physiological dysfunction, insomnia, and even life-threatening shock. Pain is the most common symptom of cancer patients, about 30-50% of cancer patients will have moderate to severe pain, especially in advanced cancer patients, about 75-95% will have uncontrollable chronic pain, of which 45% of cancer patients The severe pain cannot be relieved, and bone cancer pain is the most common refractory type among them, which seriously affects the quality of life of patients. Although WHO has regarded the treatment of cancer pain as an imp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61K9/16A61K47/38A61P29/00A61K36/232
CPCA61K9/1623A61K9/1652A61K36/232A61K36/66A61K2236/333A61K2236/39A61K2300/00
Inventor 唐玲占希陈丽姗
Owner DALIAN UNIV