Method for extracting neomycin from neomycin broth

A technology of neomycin and fermented liquid, which is applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., can solve the problems of easy damage of resin, unpleasant smell, high water consumption, etc., to reduce waste water discharge, realize The effect of clean production and simple method steps

Active Publication Date: 2016-03-23
YICHANG SANXIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. High water consumption;
[0005] 2. The resin is easily damaged;
[0006] 3. Produce a large amount of waste water;
[0007] 4. Produce an unpleasant smell

Method used

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  • Method for extracting neomycin from neomycin broth
  • Method for extracting neomycin from neomycin broth
  • Method for extracting neomycin from neomycin broth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A method for extracting neomycin from neomycin fermentation broth, the method comprises the following steps:

[0048] 1) heating: heating the neomycin fermentation broth to 65°C;

[0049] 2) Put diatomite filter aid with 2% of the mass of the neomycin fermentation broth into the heated neomycin fermentation broth, and stir evenly.

[0050] The filter aid is a diatomite filter aid;

[0051] 3) filtering the neomycin fermented liquid obtained in step 2) through a filter, separating the solid phase and the liquid phase of the neomycin fermented liquid to obtain a clear liquid containing neomycin;

[0052] 4) The supernatant liquid containing neomycin obtained in step 3) is directly carried out on the column for adsorption;

[0053] 5) Desorption, concentration, salt conversion, refining, and dusting are carried out again to obtain the finished product of neomycin.

[0054] In step 3), the filter is a plate and frame filter.

Embodiment 2

[0056] A method for extracting neomycin from neomycin fermentation broth, the method comprises the following steps:

[0057] 1) heating: heating the neomycin fermentation broth to 70°C;

[0058] 2) drop into the diatomite filter aid of neomycin fermentation liquid quality 1% in the neomycin fermentation liquid after heating, and stir evenly;

[0059] The filter aid is a diatomite filter aid;

[0060] 3) filtering the neomycin fermented liquid obtained in step 2) through a filter, separating the solid phase and the liquid phase of the neomycin fermented liquid to obtain a clear liquid containing neomycin;

[0061] 4) The supernatant liquid containing neomycin obtained in step 3) is directly carried out on the column for adsorption;

[0062]5) Desorption, concentration, salt conversion, refining, and dusting are carried out again to obtain the finished product of neomycin.

[0063] In step 3), the filter is a plate and frame filter.

Embodiment 3

[0065] A method for extracting neomycin from neomycin fermentation broth, the method comprises the following steps:

[0066] 1) heating: heating the neomycin fermentation broth to 75°C;

[0067] 2) drop into the diatomite filter aid of neomycin fermentation liquid quality 1% in the neomycin fermentation liquid after heating, and stir evenly;

[0068] The filter aid is a diatomite filter aid;

[0069] 3) filtering the neomycin fermented liquid obtained in step 2) through a filter, separating the solid phase and the liquid phase of the neomycin fermented liquid to obtain a clear liquid containing neomycin;

[0070] 4) The supernatant liquid containing neomycin obtained in step 3) is directly carried out on the column for adsorption;

[0071] 5) Desorption, concentration, salt conversion, refining, and dusting are carried out again to obtain the finished product of neomycin.

[0072] In step 3), the filter is a plate and frame filter.

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Abstract

The invention relates to a method for extracting neomycin from a neomycin broth. The method comprises the following steps: 1) heating the neomycin broth to temperature of 65-75 DEG C; 2) placing a diatomite filter aid with mass accounting for 1-2% of that of the neomycin broth in the heated neomycin broth; 3) filtering the neomycin broth prepared in the step 2) with a filter to obtain a clear liquid containing neomycin; 4) loading the clear liquid containing neomycin to directly carry out column adsorption; and 5) desorbing the clear liquid and concentrating the clear liquid to prepare the neomycin finished product. The method for extracting neomycin from the neomycin broth can solve the environmental protection problem in neomycin production, energy saving for the novel extraction technology for neomycin sulfate can be realized, and cleaning production can be realized.

Description

technical field [0001] The invention relates to the field of neomycin production, in particular to a method for extracting neomycin from neomycin fermentation broth. Background technique [0002] At present, the extraction method of neomycin products has been using the traditional process, that is, the adsorption resin is put into the neomycin fermentation liquid, and after the adsorption resin is saturated with neomycin, the resin is separated from the neomycin fermentation liquid, and then the desorption method is used. Methods Neomycin was desorbed from the resin. According to the current production scale of neomycin in the factory, at least 300 tons of neomycin fermentation liquid are produced every day. After the neomycin fermentation liquid is put into the adsorption resin for adsorption, the resin and neomycin fermentation liquid need to be separated. The extraction is sieved with an 80-mesh vibrating sieve. At the same time, a large amount of water is used for washi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/232C07H1/06
CPCC07H1/06C07H15/232
Inventor 沈联兵张国宪何连明周宜平张安莲覃清华薛勇
Owner YICHANG SANXIA PHARMA
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