Preparation method of C6-fluoroketone

A catalyst and epoxy technology, applied in the preparation of heterocyclic compounds, organic chemistry, etc., can solve the problems of low formula conversion rate, easy deactivation, unstable reaction yield, etc.

Active Publication Date: 2016-03-30
SHANGHAI 3F NEW MATERIAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This patent uses a composite catalyst, which is easy to deactivate, the reaction

Method used

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  • Preparation method of C6-fluoroketone
  • Preparation method of C6-fluoroketone

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Add 400ml of acetonitrile and 4g of metformin into a 1000mL closed reaction kettle equipped with mechanical stirring, control the reaction temperature at 45°C, add 300g of perfluoro-2,3-epoxy-2-methylpentane, and react for a total of 4 hours. After the reaction, the molar yield of perfluorohexanone was 96.5% through separation and analysis.

Embodiment 2

[0030] Add 400ml of acetonitrile and 5g of conjugated tetramethylguanidine to a 1000mL closed reaction kettle equipped with mechanical stirring, control the reaction temperature at 40°C, add 300g of perfluoro-2,3-epoxy-2-methylpentane, The total reaction time was 3 hours. After the reaction, the molar yield of perfluorohexanone was 95.5% through separation and analysis.

Embodiment 3

[0032] Add 400ml of acetonitrile and 5g of bicyclic guanidine into a 1000mL closed reaction kettle equipped with mechanical stirring, control the reaction temperature at 50°C, add 300g of perfluoro-2,3-epoxy-2-methylpentane, and react for a total of 3 hours After the reaction, the molar yield of perfluorohexanone was 94.8% through separation and analysis.

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Abstract

The invention discloses a preparation method of C6-fluoroketone. C6-fluoroketone is called perfluoro-2-methyl-3-pentanone. The method includes the steps that in the presence of an organic guanidine catalyst and a solvent, perfluoro-2,3-epoxy-2-methylpentane reacts for 1-5 hours at the temperature of 0-80 DEG C; the organic guanidine catalyst is selected from one of or a mixture of two or more of metformin, bicyclic guanidine, chlorination bicyclic guanidine, tetramethyl guanidine and conjugated tetramethyl guanidine and other guanidyl compounds. The mole yield of the product obtained through the method is larger than 95%, reaction selectivity is high, reaction conditions are mild, and the preparation method is environmentally friendly.

Description

technical field [0001] The present invention relates to a perfluorinated organic compound-perfluoro 2-methylpentan-3-one (commonly known as perfluorohexanone, molecular formula is (CF 3 ) 2 CFC(O)CF 2 CF 3 ), the inventive method has the advantages of high yield, high selectivity, mild reaction conditions and suitability for industrialized production. Background technique [0002] Perfluorohexanone is an important fluorine-containing chemical, which can be used as fire extinguishing agent, cleaning agent, protective gas and solvent for magnesium smelting, etc. Perfluorohexanone has the characteristics of low boiling point, high volatility, low toxicity, non-combustibility, outstanding environmental protection performance, will not damage the ozone layer (0DP=0), naturally decomposes in the atmosphere within 5 days, and has a global warming potential of 1 (GWP = 1), the highest fire extinguishing agent safety limit value and low vapor pressure, easy storage, good transpor...

Claims

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Application Information

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IPC IPC(8): C07C45/58C07C49/167
CPCC07C45/58C07C49/167
Inventor 陈焱锋张智勇吴君毅
Owner SHANGHAI 3F NEW MATERIAL TECH CO LTD
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