A kind of preparation method of nano gold particles
A technology of nano-gold particles and preparation process, applied in the field of preparation of nano-gold particles, can solve problems such as no successful cases, reduce tumor radiation resistance, increase tumor sensitivity, etc., and achieve the best radiosensitization effect and preparation process. Simple, easy to use, mild experimental conditions
Inactive Publication Date: 2018-06-12
QINGDAO UNIV
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Problems solved by technology
Increasing the sensitivity of tumors to radiation and reducing the radiation resistance of tumors has become a hot and difficult point in tumor research, such as increasing the dose of radiotherapy, combining radiotherapy and chemotherapy drugs, and using cell sensitizers. Sensitizers are currently an important research topic in tumor radiotherapy, but there are no satisfactory radiosensitizers in clinical practice.
However, there have been no successful cases of using gold nanoparticles to sensitize tumor radiation, and the green and environmentally friendly preparation process of gold nanoparticles still needs to be further developed and researched.
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[0013] The preparation method of the AuNPs@BSA nanomaterial described in this example is as follows: first take 5ml of bovine serum albumin (BSA) solution with a concentration of 5mg / ml and 0.5ml of chloroauric acid (HAuCl) with a concentration of 10mM 4 ) solutions were mixed, stirred with a magnetic stirrer for 10 minutes, then added 50 μl of ascorbic acid with a concentration of 1M and continued to stir with a magnetic stirrer, and after culturing at 25°C to 27°C for 12h, the particle size with bovine serum albumin as a template was prepared. 50nm gold nanoparticles AuNPs@BSA.
[0014] The AuNPs@BSA described in this example uses bovine serum albumin as a biological template. In the presence of a reducing agent, chloroauric acid is used as a raw material to synthesize gold nanoparticles with a particle size of about 50nm. The synthesized gold nanoparticles have With good stability and biocompatibility, the toxic effect of the AuNPs@BSA nanomaterial of the present invention ...
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Abstract
The invention belongs to the technical field of nanometer material preparation, and relates to a preparation method of a gold nanoparticle. 5 ml of a bovine serum albumin solution with the concentration of 5 mg / ml and 0.5 ml of a chloroauric acid solution with the concentration of 10 mM are mixed firstly, and stirred through a magnetic stirrer for 10 min; then 50 microliters of ascorbic acid with the concentration of 1 M is added, and the magnetic stirrer continues stirring; and after cultivation is carried out for 12 h at the temperature of 25-27 DEG C, the gold nanoparticle AuNPs@BSA with bovine serum albumin as a template and with the particle diameter of 50 nm is prepared. The prepared gold nanoparticle AuNPs@BSA can be used for radiosensitization in cancer radiotherapy. The preparation process of the gold nanoparticle is simple and easy to implement, the experiment condition is moderate, and adopted experiment reagents are cheap and easy to obtain. In-vitro and in-vivo experiments verify that nanometer materials obtained through synthesis are free of toxic action, and biocompatibility is good.
Description
Technical field: [0001] The invention belongs to the technical field of nanomaterial preparation, and in particular relates to a method for synthesizing gold nanoparticles by a biological template method and its application in radiosensitization in cancer treatment, in particular to a preparation method for nanometer gold particles. Background technique [0002] Since the advent of nanomaterials, due to their superior electrical, magnetic, and optical properties, they have received widespread attention. The types and preparation methods of nanomaterials have also become more and more diverse with the increase of research efforts. Common nanomaterials mainly include metal nanomaterials (gold, silver, platinum, copper and their alloys), sulfide nanomaterials, oxide nanomaterials, and carbonate nanomaterials. There are a wide range of applications in the biomedical field. At present, the preparation ideas of nanomaterials can be summarized into two directions, that is, the "to...
Claims
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IPC IPC(8): B22F9/24
CPCB22F9/24
Inventor 崔莲花杨大鹏刘树亮
Owner QINGDAO UNIV