Voriconazole compound aqueous emulsion preparation for treating fungal skin diseases in pets

A technology for voriconazole and skin diseases, which is applied in the field of voriconazole compound water-emulsion preparations, which can solve the problems of inconvenient pet tablets, inability to meet pet medicines, and no voriconazole preparations in the pet field, and achieve low production costs, reasonable design, and economic benefits promising effect

Inactive Publication Date: 2016-04-13
HUAIHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing technology can’t satisfy pet medicine: 1. It is inconvenient for pets to take tablets, 2. There is no voriconazole preparation in the field of pets

Method used

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Embodiment Construction

[0008] In order to make the object, technical solution and advantages of the present invention more clear, the following specific embodiments will further describe the present invention in detail. It should be understood that the specific embodiments described here are only used to explain the present invention, and are not intended to limit the present invention.

[0009] The main formula material of this specific embodiment has voriconazole, tinidazole, dexamethasone, and other auxiliary materials also include Tween 80, propylene glycol, purified water; The quality proportioning of above-mentioned formula material is voriconazole (5-15g): Tinidazole (3-8g): dexamethasone (0.5-2g): Tween 80 (25-35ml): propylene glycol (25-35ml): purified water (80-120ml).

[0010] The production process of the formula is as follows: ① heat Tween 80 (30ml) and propylene glycol (30ml) in a container, ② pour voriconazole (10g), tinidazole (5g) and dexamethasone (1g) while heating, ③ Heat until ...

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Abstract

The invention discloses a voriconazole compound aqueous emulsion preparation for treating fungal skin diseases in pets, and relates to the technical field of a medicine. The preparation mainly consists of the following materials according to a formula: voriconazole, tinidazole and dexamethasone, and further consists of the following adjuvant materials: tween-80, propanediol and pure water, wherein the mass percentage of the formula materials is at (5-15g) to (3-8g) to (0.5-2g) to (25-35ml) to (25-35ml) to (80-120ml) of the voriconazole to the tinidazole to the dexamethasone to the tween-80 to the propanediol to the pure water; and a preparation technology of the formula comprises the following processes: (1) heating the tween-80 (30ml) and the propanediol (30ml) in a container; (2) while heating, pouring the voriconazole (10g), the tinidazole (5g) and the dexamethasone (1g); (3) heating until the materials are dissolved, and stopping warming up; and (4) adding the pure water to 100ml, and uniformly stirring, so that the preparation is obtained. The preparation disclosed by the invention has the beneficial effects that the preparation can solve difficulties in skin repair treatment of fungal pyoderma in the pets; the preparation is broad in economic benefit and prospect and is considerable in benefit; and the preparation has the advantages of simple materials, reasonable design, low preparation cost and the like.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a voriconazole compound water-emulsion preparation for pet fungal skin diseases. Background technique [0002] At present, there are only voriconazole tablets for human use in China, and there are voriconazole freeze-dried powder injections abroad, but there are no other dosage forms, and there is no compound voriconazole water emulsion. Voriconazole Tablets, Indications This product is a broad-spectrum triazole antifungal drug, and its indications are as follows: treatment of invasive aspergillosis. Treatment of severe invasive infections caused by fluconazole-resistant Candida species (including Candida krusei). Treatment of serious infections caused by Actinomycetes and Fusarium species. This product should be used primarily for the treatment of progressive, potentially life-threatening infections in immunocompromised patients. [0003] The prior art cannot satisfy pet me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/573A61P31/10A61P17/00A61K31/4164A61K31/506
CPCA61K31/4164A61K9/107A61K31/506A61K31/573A61K47/10A61K47/26A61K2300/00
Inventor 苏振霞李相国肖辉
Owner HUAIHAI INST OF TECH
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