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Triterpenoid saponins compound, and preparation method and uses thereof

A technology of triterpenoid saponins and compounds, which is applied in the field of medicine, can solve the problems that the structure of natural ginsenosides is not in the best state of structure and has not been developed and utilized, and achieves obvious anti-tumor activity and good anti-tumor effect.

Inactive Publication Date: 2016-04-13
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at the same time, Panax notoginseng is a traditional Chinese herbal medicine, and the uses of many components have not been developed and utilized.
Notoginseng saponin is its main active ingredient, but according to the metabolism of ginsenoside in the body and its structure-activity relationship, "ginsenoside" is absorbed by the gastrointestinal tract and then metabolized by intestinal bacteria into secondary saponins and glycosides. Absorbed into the blood circulation to play a pharmacological role, indicating that the structure of natural ginsenosides is not the best structure

Method used

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  • Triterpenoid saponins compound, and preparation method and uses thereof
  • Triterpenoid saponins compound, and preparation method and uses thereof
  • Triterpenoid saponins compound, and preparation method and uses thereof

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Experimental program
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Effect test

Embodiment 1

[0042] One, a kind of triterpene saponin compound structure that the present invention relates to is as follows:

[0043]

[0044] Its chemical name is: 6-O-β-D-glucopyranosyl-Dama-17β(H)-20(22)(E)-ene-3β,6α,12β,24S,25-pentaol. The triterpene saponins compound of the present invention is a new compound isolated for the first time from the transformation product of Panax notoginseng, named as ginsenoside ST-8.

[0045] The physicochemical constants of triterpene saponins compound described in the present invention are as follows:

[0046] White powder (methanol), ESI-MS: m / z677.42 ([M+Na] + ), m / z689.40 ([M+Cl] – ), combined with hydrogen spectrum and carbon spectrum, it is speculated that its molecular formula is C 36 h 62 o 10 . 10% sulfuric acid ethanol solution was purple, Molish reaction was positive, Liebermann-Burchard reaction was positive. 1 H and 13 See Table 1 for C-NMR data.

[0047] Table 1 of compounds 1 H-NMR, 13 C-NMR data attribution information ...

Embodiment 2

[0069] Embodiment 2: Antitumor activity test of the compound of the present invention

[0070] 1. Test materials

[0071] 1. Tumor strains tested in vitro:

[0072] Helas human cervical cancer cells were provided by the Pharmacology Laboratory of the R&D Center of Changchun University of Traditional Chinese Medicine.

[0073] 2. Reagents for in vitro tests:

[0074] Neonatal bovine serum, dimethyl sulfoxide (DMSO) and MTT tetrakis salt (Sigma).

[0075] 3. In vitro test equipment:

[0076] Microplate reader: Multiskan Ascent, model: VL.23354-00541T.

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Abstract

The invention belongs to the technical field of medicines, and discloses a triterpenoid saponins compound, and a preparation method and uses thereof. The triterpenoid saponins compound is 6-O-beta-D-glucopyranosyl-dammara-17beta(H)-20(22)(E)-ene-3beta,6alpha,12beta,24S,25-pentol, and the structure formula is shown in the specification. The chemical structure of the triterpenoid saponins compound is determined by employing mass spectrum and one-dimension and two-dimension nuclear magnetic resonance spectrum technologies and chemical methods. In-vitro antitumor activity tests show that the triterpenoid saponins compound possesses obvious antitumor activity and provides a new source for preparing antitumor medicines.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to triterpene saponins and their preparation methods and uses. Background technique [0002] Panax notoginseng is the dry root and rhizome of Panax notoginseng of the Araliaceae plant. In my country's Yunnan, Guangxi and other places. This product is warm in nature, sweet in taste, slightly bitter, non-toxic. The raw product of Panax notoginseng can reduce swelling and relieve pain, dissipate blood stasis and stop bleeding, and the cooked product can enrich blood and activate blood circulation. Panax notoginseng has a long history of being used to treat diseases, and it is one of the traditional precious medicinal materials commonly used in my country. For thousands of years, it has made great contributions to the prosperity of the Chinese nation, and is deeply concerned and valued by people all over the world. [0003] Nowadays, the rapid development of modern scie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J17/00C12P33/20A61K31/704A61P35/00C12R1/645
Inventor 邱智东徐伟
Owner CHANGCHUN UNIV OF CHINESE MEDICINE