Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Triterpenoid saponin compound and preparation method and application thereof

A technology for triterpenoid saponins and compounds, applied in the field of medicine, can solve the problems that have not been developed and utilized, and the structure of natural ginsenosides is not in the optimal state of structure, and achieve the effect of obvious anti-tumor activity and good anti-tumor effect.

Inactive Publication Date: 2016-05-11
CHANGCHUN UNIV OF CHINESE MEDICINE
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at the same time, Panax notoginseng is a traditional Chinese herbal medicine, and the uses of many components have not been developed and utilized.
Notoginseng saponin is its main active ingredient, but according to the metabolism of ginsenoside in the body and its structure-activity relationship, "ginsenoside" is absorbed by the gastrointestinal tract and then metabolized by intestinal bacteria into secondary saponins and glycosides. Absorbed into the blood circulation to play a pharmacological role, indicating that the structure of natural ginsenosides is not the best structure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Triterpenoid saponin compound and preparation method and application thereof
  • Triterpenoid saponin compound and preparation method and application thereof
  • Triterpenoid saponin compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] One, a kind of triterpene saponin compound structural formula that the present invention relates to is as follows:

[0044]

[0045] Its chemical name is: said triterpenoid saponins compound is the new compound that is isolated from the notoginseng conversion product for the first time, named ginsenoside: 6-O-β-D-glucopyranosyl-Dama-17α (H )-20(22)(E)-ene-3β,6α,12β,24S,25-pentaol. The name of the triterpene saponins compound of the present invention is ginsenoside ST-7.

[0046] The physicochemical constants of triterpene saponins compound described in the present invention are as follows:

[0047] White powder (methanol), ESI-MS: m / z677.42 ([M+K] + ), combined with hydrogen spectrum and carbon spectrum, it is speculated that its molecular formula is C 36 h 62 o 9 . 10% sulfuric acid ethanol solution was purple, Molish reaction was positive, Liebermann-Burchard reaction was positive. 1 H and 13 See Table 1 for C-NMR data.

[0048] 1H-NMR, 13C-NMR data attrib...

Embodiment 2

[0070] Embodiment 2: Antitumor activity test of the compound of the present invention

[0071] 1. Test materials

[0072] 1. Tumor strains tested in vitro:

[0073] Helas human cervical cancer cells were provided by the Pharmacology Laboratory of the R&D Center of Changchun University of Traditional Chinese Medicine.

[0074] 2. Reagents for in vitro tests:

[0075] Newborn bovine serum, dimethyl sulfoxide (DMSO) and MTT tetraoxalate (Sigma).

[0076] 3. In vitro test equipment:

[0077] Microplate reader MultiskanAscent model VL.23354-00541T.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine and discloses a triterpenoid saponin compound and a preparation method and application thereof. The triterpenoid saponin compound is 6-O-beta-D-glucopyranosyl group-dammar-17 alpha (H)-20 (22) (E)- alkenyl-3 beta, 6 alpha, 12 beta, 24S, 25-pentol. The structural formula is shown in the description. The chemical structure of the triterpenoid saponin compound is determined by using the mass spectrum and one-dimensional and two-dimensional nuclear magnetic resonance spectrum technology and a chemical method. In-vitro anti-tumor activity experiments indicate that the triterpenoid saponin compound has evident anti-tumor activity, and a new source is provided for the preparation of anti-tumor drugs.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to triterpene saponins and their preparation methods and applications. Background technique [0002] Panax notoginseng is the dry root and rhizome of Panax notoginseng of the Araliaceae plant. In my country's Yunnan, Guangxi and other places. This product is warm in nature, sweet in taste, slightly bitter, non-toxic. The raw product of Panax notoginseng can reduce swelling and relieve pain, dissipate blood stasis and stop bleeding, and the cooked product can enrich blood and activate blood circulation. Panax notoginseng has a long history of being used to treat diseases, and it is one of the traditional precious medicinal materials commonly used in my country. For thousands of years, it has made great contributions to the prosperity of the Chinese nation, and is deeply concerned and valued by people all over the world. [0003] Nowadays, the rapid development of mod...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07J17/00C12P33/20A61P35/00C12R1/645
Inventor 邱智东徐伟
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com