Chitosan tablets and preparation method thereof

A chitosan and tablet technology, which is applied in the directions of antidote, pill delivery, pharmaceutical formulation, etc., can solve the problems of easy rebound, difficult tableting of chitosan, poor compressibility, etc., and achieves extended shelf life, stable physical and chemical properties, The effect of improving the appearance

Active Publication Date: 2016-04-20
GUANGDONG PHARMA UNIV
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Problems solved by technology

Therefore, chitosan is also a kind of therapeutic drug and preventive health care drug with good physiological activity. However, there are few studies on the oral preparation and process of chitosan at present.
But because chitosan belongs to the raw powder of traditional Chinese medicine, contains more cellulose, has poor compressibility, and is easy to rebound after tableting, therefore, it is necessary to develop a tablet formula to solve the problem of chitosan being difficult to tablet Provide the chitosan tablet with good stability to ensure the stable performance of its drug effect

Method used

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  • Chitosan tablets and preparation method thereof
  • Chitosan tablets and preparation method thereof
  • Chitosan tablets and preparation method thereof

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preparation example Construction

[0021] The preparation method of the embodiment of the present invention 1~4 chitosan tablet:

[0022] S1, taking zein, hydroxypropyl methoxycellulose and polyethylene glycol and adding them to ethanol with a volume fraction of 30-40%, stirring evenly to obtain a coating solution;

[0023] S2, respectively drying chitosan, crospovidone, calcium hydrogen phosphate, microcrystalline cellulose and micropowder silica gel, pulverizing, passing through a 100-mesh sieve, and setting aside;

[0024] S3, take sodium carboxymethyl cellulose, and use water to prepare a sodium carboxymethyl cellulose solution with a weight concentration of 5%, for subsequent use;

[0025] S4. Mix chitosan with calcium hydrogen phosphate, crospovidone and microcrystalline cellulose evenly with equal amount addition method, add sodium carboxymethyl cellulose solution under stirring to make soft material, granulate, and pass through a 18-mesh sieve , dried at 40°C, sieved, granulated, added with micro-powde...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations and particularly relates to chitosan tablets and a preparation method thereof. The chitosan tablets comprise tablet cores and coating layers, wherein the tablet cores comprise components in parts by weight as follows: 70-76 parts of chitosan, 3-6 parts of crospovidone, 7-12 parts of calcium hydrogen phosphate, 8-12 parts of microcrystalline cellulose, 1-3 parts of aerosil and 4-6 parts of sodium carboxymethyl cellulose; the coating layers are prepared from raw materials in parts by weight as follows: 4-6 parts of zein, 7-9 parts of hydroxypropyl methoxyl cellulose, 3-5 parts of polyethylene glycol and 80-84 parts of ethyl alcohol with the volume fraction of 30%-40%. The chitosan tablets have bright and clean appearance and are stable in physical and chemical properties and long in shelf life, and the disintegration time, hardness, friability and the like agree with related regulations of the Chinese pharmacopoeia.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a chitosan tablet and a preparation method thereof. Background technique [0002] Chitosan (chitosan), also known as deacetylated chitin, is obtained from chitin (chitin), which exists widely in nature, through deacetylation. It is one of the most abundant natural polymers on the earth, and its content is second only to cellulose. , whose chemical name is polyglucosamine (1-4)-2-amino-B-D glucose. Since the Frenchman Rouget first obtained chitosan in 1859, the excellent properties of this natural polymer, such as biofunctionality, compatibility, blood compatibility, film-forming property, safety, and microbial degradation, have been widely recognized by all walks of life. It has been widely concerned and has made significant progress in applied research in many fields such as medicine, food, chemical industry, cosmetics, water treatment, metal ext...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/38A61K31/722A61P9/12A61P37/04A61P3/06A61P39/02
CPCA61K9/2054A61K9/2873A61K31/722
Inventor 苏政权郭姣杨晴云
Owner GUANGDONG PHARMA UNIV
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