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Pharmaceutical formula capable of lowering blood glucose and experiment method of pharmaceutical formula

An experimental method and blood sugar-lowering technology, which is applied in the pharmaceutical industry, can solve the problems of lack of microscopic analysis and quality control of medicinal substances in compound decoctions, and affect clinical curative effects, so as to achieve the effects of lowering blood sugar, improving blood sugar, and improving insulin resistance

Inactive Publication Date: 2016-04-20
SHAANXI UNIV OF CHINESE MEDICINE
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Problems solved by technology

[0003] Gegen Qinlian Decoction has been verified by clinical practice to have an intervention treatment effect on type 2 diabetes and insulin resistance, but the compound decoction lacks microscopic analysis and quality control of medicinal substances, which affects clinical efficacy. The ratio of active ingredients was studied to discover and optimize the ratio of the best effective components of Gegen Qinlian Decoction for the intervention and treatment of type 2 diabetes, providing a research basis for the secondary development of such classic prescriptions

Method used

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  • Pharmaceutical formula capable of lowering blood glucose and experiment method of pharmaceutical formula
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  • Pharmaceutical formula capable of lowering blood glucose and experiment method of pharmaceutical formula

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Embodiment Construction

[0016] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention and are not intended to limit the invention.

[0017] from figure 1 It can be seen that the experimental scheme among the present invention is as follows:

[0018] 1. Establishment of hyperglycemia rat model

[0019] 1.1 Experimental animal grouping and modeling

[0020] 140 healthy male SD rats aged 8-9 weeks were provided by the Animal Experiment Center of the Fourth Military Medical University, with a body weight of 280-300 g, and were fed adaptively for 7 days. They were divided into blank group and model group according to the random number table method, and blank group 10 rats, 130 rats in the model group, the blank group ...

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Abstract

The invention relates to the technical field of a pharmaceutical industry and in particular relates to a pharmaceutical formula capable of lowering blood glucose and an experiment method of the pharmaceutical formula. The pharmaceutical formula capable of lowering the blood glucose is prepared from the following raw materials according to concentration ratios: 100mg / kg.d of puerarin, 25mg / kg.d of isoflavoues aglycone, 100mg / kg.d of baicalin, 10mg / kg.d of baicalein, 10mg / kg.d of berberine, 5mg / kg.d of glycyrrhizic acid and 50mg / kg.d of liquiritin. The experiment method of the pharmaceutical formula capable of lowering the blood glucose comprises the following experiment steps: (1) establishing rat hyperglycemia models; (2) sieving and grouping; (3) detecting indicators; (4) analyzing and comparing to obtain a conclusion. The formula provided by the invention is obtained by strict scientific experiments and has very good effects of lowering the blood glucose and improving insulin resistance, can provide a research foundation for secondary development of classic prescriptions and has very high innovation.

Description

technical field [0001] The invention relates to the technical field of the pharmaceutical industry, in particular to a drug formula for lowering blood sugar and an experimental method thereof. Background technique [0002] Clinical and experimental studies have reported that Gegen Qinlian Decoction has a therapeutic effect on diabetes. Among them, Gegen Qinlian Decoction contains a large number of compounds of different polarities such as flavonoids, isoflavones, alkaloids, saponins, etc. These substances are completely obtained and comprehensively treated Research has been difficult, and it's unclear exactly which compounds are at work. Based on relevant literature, we selected 7 compounds with strong activity from Gegen Qinlian Decoction: ①Flavonoids derived from Pueraria root: puerarin, daidzein; ②Flavonoids derived from Scutellaria baicalensis: baicalin, baicalein; ③ Alkaloids derived from Coptidis Rhizoma: berberine; ④ Glycyrrhizic acid and liquiritin derived from lico...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/704A61K31/4375A61K31/352A61P3/10A61K49/00
CPCA61K31/352A61K31/4375A61K31/704A61K31/7048A61K49/0008A61K2300/00
Inventor 胡锐张晓双智冰清
Owner SHAANXI UNIV OF CHINESE MEDICINE
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