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A kind of method and its application of promoting the re-growth of silver on the surface of gold nanosphere

A technology of regrowth and gold nanoparticles, applied in the field of nanoparticles, can solve the problems of distinguishing homocysteine ​​and glutathione, high detection limit, accelerating the rapid growth of silver, etc. Simple steps and highly reproducible results

Active Publication Date: 2017-11-28
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the shortcomings of existing studies at room temperature and without changing the pH, silver regrowth is very slow, and the detection limit of cysteine ​​is high and it cannot be well compared with homocysteine ​​and glutathione Distinguishing the problems of separation, etc., the present invention proposes a method and its application to promote the re-growth of silver on the surface of gold nanoparticles, which can not only accelerate the rapid growth of silver on the surface of gold particles without changing the pH, but also can grow at 70°C. It is completed in about 40 minutes, and has a certain control effect on the morphology of the silver shell

Method used

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  • A kind of method and its application of promoting the re-growth of silver on the surface of gold nanosphere
  • A kind of method and its application of promoting the re-growth of silver on the surface of gold nanosphere
  • A kind of method and its application of promoting the re-growth of silver on the surface of gold nanosphere

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Effect test

Embodiment 1

[0070] Gold nanospheres (20 nm in diameter) at a final atomic concentration of 0.1 mM and cysteine ​​at a final concentration of 20 μM were added to an aqueous CTAB solution at a concentration of 10 mM. After the mixed solution was incubated in a water bath at 30°C for 30 min, silver nitrate with an atomic molar ratio of 2 to gold nanospheres, namely AgNO 3 The final concentration was 0.2 mM; the reducing agent ascorbic acid with a molar ratio of silver nitrate of 10 was added, that is, the final concentration of ascorbic acid was 2 mM. Place it in a 70°C environment to grow into a gold-silver core-shell Au@Ag structure. During this process, a UV-Vis-IR absorption spectrometer was used to record its extinction spectrum changes at intervals of 2 min, such as figure 1 -b shown. It can be seen from the figure that it takes only 40 minutes for the silver regrowth to be basically completed.

[0071] The final concentrations of cysteine ​​were adjusted to 2 μM, 5 μM, 10 μM, 20 μM...

Embodiment 2

[0073] Centrifuge the Au@Ag structure solution with different concentrations of cysteine-assisted growth in Example 1 for 5 minutes at a speed of 9200rmp to obtain the gold-silver nano-core-shell structure, and perform TEM characterization, the results are as follows figure 2 shown. It can be seen from the figure that adding different concentrations of cysteine ​​can change the morphology of the Au@Ag core-shell structure. As the concentration of cysteine ​​increases, the square structure is gradually replaced by the spherical structure, and finally Mainly spherical structure.

Embodiment 3

[0075] Add gold nanospheres (20 nm in diameter) with a final atomic concentration of 0.1 mM to the CTAB aqueous solution with a concentration of 10 mM, and then add cysteine, cysteine ​​methyl ester, cysteamine, and p-amino Thiophenol and homocysteine ​​at a final concentration of 1 μM. After placing the mixed solution in a water bath at 30°C for 30 minutes, add a final concentration of 0.2mM silver nitrate and 2mM ascorbic acid, and measure the spectrum after growing in a 70°C environment for 45 minutes. The results are as follows: image 3 As shown in -a, cysteine ​​methyl ester, cysteamine, p-aminothiophenol, and homocysteine ​​at a final concentration of 1 μM, the test results show that small molecular compounds containing both functional groups sulfhydryl and amino groups have the ability to accelerate silver The role of regrowth. image 3 -b is the TEM image of the Au@Ag structure assisted by cysteine ​​methyl ester, cysteine ​​and p-aminothiophenol growth, indicating t...

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Abstract

The invention provides a method for promoting the re-growth of silver on the surface of gold nanoparticles and its application. The method of the present invention includes that in the synthesis of gold-core-silver-shell composite nanoparticles, for the first time, the regrowth of silver on the surface of gold nanoparticles is regulated by adding small molecular compounds containing functional groups of mercapto and amino groups, wherein, the The distance between the thiol and amino groups of small molecular compounds is less than 6 carbon atoms. In addition, the method of the present invention can realize the detection of trace cysteine ​​concentration, and can be used to distinguish between reduced glutathione and cysteine ​​and to distinguish between homocysteine ​​and cysteine. The above method has the characteristics of simplicity, speed, safety and strong repeatability.

Description

technical field [0001] The invention relates to the technical field of nanoparticles, in particular to a method for silver regrowth and its application, in particular to a method for promoting silver regrowth on the surface of gold nanoparticles and its application. Background technique [0002] At present, cetyltrimethylammonium bromide (CTAB) is used as surfactant in the synthesis of gold-silver core-shell nanostructures, and ascorbic acid or hydroxylamine are weakly used as reducing agents. Since the reduced form of ascorbic acid is stronger under alkaline conditions, most of the reported methods use the method of adding alkali to promote the regrowth of silver. Growth is very slow at room temperature without changing the pH. It also takes 4 hours for R.B.Jiang et al. to perform the reaction at a higher temperature (65°C) (R.B.Jiang, H.J.Chen, L.Shao et al, Unraveling the Evolution and Nature of the Plasmons in (Au Core)-(Ag Shell) Nanorods, Adv. Mater. 2012, 24:200-207...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F1/02C23C18/44G01N21/31
CPCG01N21/31C23C18/44B22F1/17
Inventor 陈佳琪侯帅吴晓春
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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