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Preparation method and application of hyaluronic acid plural gel

A composite gel and hyaluronic acid technology, applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of unfavorable medical product production, raw material degradation, cumbersome operation, etc., and achieve good biocompatibility and homogeneity Good, uniform cross-linking effect

Active Publication Date: 2016-04-20
HANGZHOU SINGCLEAN MEDICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method needs to dilute and concentrate the system. It has many steps and complicated operation, which is not conducive to the production of medical products. At the same time, there are problems such as degradation of raw materials caused by intermediate steps.

Method used

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  • Preparation method and application of hyaluronic acid plural gel
  • Preparation method and application of hyaluronic acid plural gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The reaction system for preparing the gel was established. 1% NaOH solution well known to those skilled in the art is selected as the lye, glycidyl ether is used as the crosslinking agent, and a constant temperature shaker is used for the mixing equipment. Dissolve 10.0g of hyaluronic acid in 200ml of lye, add the crosslinking agent according to the hyaluronic acid:crosslinking agent mass ratio of 2:1 to 20:1, add collagen, and mix well at 22°C and shaking frequency of 300rpm.

Embodiment 2

[0034] The reaction system for preparing the gel was established. 1% NaOH solution well known to those skilled in the art is selected as the lye, glycidyl ether is used as the crosslinking agent, and a constant temperature shaker is used for the mixing equipment. Dissolve 10.0g of hyaluronic acid in 200ml of lye, add crosslinking agent according to hyaluronic acid:crosslinking agent mass ratio of 2:1 to 18:1, add dextran particles, and mix well at 20°C and oscillation frequency of 220rpm.

Embodiment 3

[0036] The reaction system for preparing the gel was established. 1% NaOH solution well known to those skilled in the art is selected as the lye, glycidyl ether is used as the crosslinking agent, and a constant temperature shaker is used for the mixing equipment. Dissolve 10.0g of hyaluronic acid in 200ml of lye, add a crosslinking agent according to the mass ratio of hyaluronic acid: crosslinking agent 2:1 to 18:1, add chitosan, and mix well at 20°C and an oscillation frequency of 350rpm .

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Abstract

The invention relates to the field of hyaluronic acid plural gel and particularly relates to a preparation method of hyaluronic acid plural gel. According to the preparation method, homogenizing of a crosslinking system and the prepared gel is realized through the combination of multiple parameters in multiple time periods, and sufficient uniform mixing of the system is realized through low-temperature and high-frequency oscillation in earlier stage; and in the middle and later stages, different oscillation frequencies are set to promote reactions producing gel and reduce gel damage in the preparation process so as to obtain a new plural gel. The invention also provides an application of the plural gel in medical treatment or prevention.

Description

technical field [0001] The invention relates to the field of a hyaluronic acid composite gel, in particular to a preparation method of a hyaluronic acid composite gel, so as to obtain a new composite gel. The new gel has medical applications. Background technique [0002] Hyaluronic acid is a linear polymer mucopolysaccharide composed of glucuronic acid and N-acetylglucosamine disaccharide units. The gel prepared from it is widely used in the medical field. The gel is hyaluronic acid cross-linked and modified into infinite prepared with a network structure. In order to improve the performance of the gel and expand its application, a composite gel was prepared by combining hyaluronic acid with other viscoelastic media for soft tissue implantation. Due to the high viscosity of hyaluronic acid after dissolution, it is easy to cause problems such as poor system homogeneity and uneven reaction. After mixing with other soft tissue implanted viscoelastic media, it will increase t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08B37/08A61L27/20A61L27/52A61L27/50A61L31/04A61L31/14
CPCA61L27/20A61L27/50A61L27/52A61L31/042A61L31/14A61L31/145A61L2400/06C08B37/0072C08J3/075C08J2305/08
Inventor 丁金聚刘丽徐小慧杨鹏孙伟庆
Owner HANGZHOU SINGCLEAN MEDICAL PROD
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