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A kind of ascorbyl glucoside crystalline powder and its preparation method

A technology of ascorbyl glucoside and crystalline powder, which is applied in the field of ascorbyl glucoside crystalline powder and its manufacture, can solve the problems of light transmittance defect, production cost consumption, excessive discharge of waste water, etc., so as to ensure good quality, reduce waste water discharge, improve Transparency effect

Active Publication Date: 2019-05-17
CHANGXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The ascorbyl glucoside products produced by related enterprises not only have a purity of over 99%, but also have a considerable output. The industrial production of ascorbyl glucoside in my country has begun to take shape, but there are still low conversion rates, especially for substrate materials. There are many problems such as low utilization rate of VC, serious consumption of production cost, low yield of product extraction, excessive discharge of wastewater, serious environmental pollution, etc.
And ascorbyl glucoside itself also has defects in light transmittance. After its concentration is greater than 20w / v%, the aqueous solution tends to be yellow, which affects the commercial value of the product.

Method used

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  • A kind of ascorbyl glucoside crystalline powder and its preparation method
  • A kind of ascorbyl glucoside crystalline powder and its preparation method
  • A kind of ascorbyl glucoside crystalline powder and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A kind of manufacture method of ascorbyl glucoside crystalline powder, comprises the steps:

[0045] one, convert

[0046] Feeding: Add excessive L-ascorbic acid or L-ascorbic acid and its salt, β-cyclodextrin, and the mass ratio of L-ascorbic acid or L-ascorbic acid and its salt to β-cyclodextrin is 10:12-16. Then add 2% to 10% of the substrate mass antioxidant (NaHSO 3 、Na 2 SO 3 、Na 2 S 2 o 5 any one), adjust the pH to 4.5 to 5.5, feed nitrogen with a purity of ≥99% at 35°C to 45°C, add cyclodextrin glucosyltransferase, and stir for 20 to 26 hours until the concentration of ascorbyl glucoside is The conversion stops at 120g / L~140g / L.

[0047] Hydrolysis: Then raise the temperature to 42-50°C, add glucoamylase and stir for 3-4 hours.

[0048] Removal of residual reducing sugar: then adjust the pH to 5.0-6.0 at a temperature of 30-40°C, add the yeast, stir and activate with air, then stop the air and continue stirring for 8-15 hours.

[0049] Heat sterilizat...

Embodiment 2

[0065] A kind of manufacture method of ascorbyl glucoside crystalline powder, its step is basically the same as embodiment 1, but conversion step is specifically as follows:

[0066] 1. Feeding

[0067] 1) Turn on the air compressor, nitrogen generator and its inlet and outlet valves successively. Make sure N 2 Purity ≥ 99.95%, nitrogen generator outlet N 2 The flow rate is controlled at 1.2~1.4N·m 3 / h. Lead the nitrogen line into the conversion tank.

[0068] 2) Inject 10M water into the conversion tank 3. Turn on the stirring and raise the temperature of the water to 40°C.

[0069] 3) Put in 1800kg VC. Rinse the VC residue stuck to the tank wall with water. Use 30-40w / v% NaOH to adjust the pH to about 4.8; if VCNa is used as the substrate, it can be added in equimolar amounts, and a small amount of L-ascorbic acid and L-sodium ascorbate (mass ratio of about 1 : 6), make the pH of the conversion system around 4.8.

[0070] 4) Put in 2800kg of β-cyclodextrin.

[0...

Embodiment 3

[0084] Example 3 7m 3 Purification process of conversion liquid

[0085] A kind of manufacture method of ascorbyl glucoside crystalline powder, its step is basically the same as embodiment 1, but purification step is specifically as follows:

[0086] 7m 3 The substrate dosage of the transformation system for transformation is: β-cyclodextrin 1400kg, VC 900kg. After the conversion, ascorbyl glucoside 165.2g / L was obtained, and the remaining VC was 34.8g / L. According to the generation amount of ascorbyl glucoside, the theoretical utilization total amount of VC in the conversion was calculated to be 601kg. Therefore, the theoretical utilization rate of VC was 67%. The actual total remaining VC is 243.6kg.

[0087] 1. Microfiltration system

[0088] Microfiltration membrane model: PL-M-132, manufacturer: Anhui Pulang Membrane Technology Co., Ltd.

[0089] The microfiltration system is used to remove impurities such as bacteria and miscellaneous proteins. The microfiltration p...

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Abstract

The invention discloses ascorbate glucoside crystalline powder and a preparation method thereof, and belongs to the field of biochemical engineering. According to the ascorbate glucoside crystalline powder, by improving the transformation concentration of ascorbate glucoside crystalline, impurities and pigments in a transformation system are removed through a multi-stage membrane separation technology, and the ascorbate glucoside crystalline is separated from ascorbate to further concentrate and recycle the ascorbate; mother liquor is filtered under an acidic environment, and the light transmittance of a product is improved; meanwhile, the problem of browning caused by easy oxidization of the ascorbate glucoside crystalline in the drying process is solved by adopting a vacuum microwave drying technology.

Description

technical field [0001] The invention relates to the field of biochemical production, in particular to an ascorbyl glucoside crystalline powder and a manufacturing method thereof. Background technique [0002] Ascorbyl glucoside, also known as ascorbyl glucoside, 2-O-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid-2-glucoside, L-ascorbic acid-2-glucoside, hereinafter referred to as AA -2G. Ascorbyl glucoside is the most stable and best-performing L-ascorbic acid substitute found so far. Under the action of enzymes in vivo, it is easily decomposed into D-glucose and VC, which has extremely high safety. It is mainly used as a Whitening additives are used in a variety of high-end brand cosmetics, and can also be used in the food and beverage industry as stabilizers, quality improvers, physiologically active agents, ultraviolet absorbers, etc., and can also be used as chemical and pharmaceutical raw materials in the pharmaceutical industry and health care products in the fi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P19/60C12P19/20C12P19/18C07H17/04C07H1/06
CPCC07H1/06C07H17/04C12P19/18C12P19/20C12P19/60
Inventor 肖延铭杨卫华吴斌谈聪
Owner CHANGXING PHARMA
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