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Characterization of rice

A characterization, rice genus technology, applied in skin care preparations, the function of food ingredients, medical preparations containing active ingredients, etc., can solve problems such as weight gain, unmet clinical needs, edema, etc.

Inactive Publication Date: 2016-04-20
PHYTOQUEST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Metformin and alpha-glucosidase inhibitors often cause gastrointestinal problems, and PPAR agonists often cause increased weight gain and edema
In particular, there remains a real and significant unmet clinical need for an effective drug capable of treating both type 2 and type 1 diabetes and related conditions while having fewer side effects than current drug therapies

Method used

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  • Characterization of rice
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  • Characterization of rice

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1: imino sugar in black rice (black rice, BlackRice)

[0086] Black rice from Italy (Gallo Venere Riso Nero - 26 / 04 / 15 Sales - 80011420002782) was extracted in boiling water normally used for cooking, and the samples were ground and extracted in cold 50% aqueous ethanol. Both extracts were filtered and subjected to H + The form of strong acid cation exchange resin IR120 is graded. After washing with water, the retained material was replaced with 2M ammonia solution and the volume was reduced by rotary evaporation. Then, the IR120 retained part of the cold-extracted material was placed on an anion exchange resin (CG400OH - form) was further separated into bound and unbound samples. All fractions (fractions, fractions) were assayed against a panel of glycosidases and they showed inhibition of α- and β-glucosidases, probably due to fagomine and DNJ, but additionally they strongly inhibited α- and β-glucosidases β-galactosidase (α-andβ-galactosidase) and tw...

Embodiment 2

[0096] Example 2. The fagomine content of commercialized rice grains (rice grains, ricegrains)

[0097] Some rice varieties are said to have a lower GI index than others (eg, brown basmati).

[0098] A select group of supermarket rice products were extracted in 50% aqueous ethanol and analyzed using cation exchange chromatography (IR120H + form) to condense the amino acid fraction. Fagomine and possibly other iminosugars were found in some varieties claimed to have a low GI index (e.g., brown basmati and Thai jasmine rice) and absent or in significant concentrations in others (e.g., long-grain white rice) lower. 1-Deoxynojirimycin (DNJ) is also present in some species. Glucuronidase (glucuronidase) inhibition was measured, which indicated that iminoglycolic acid may also be present. Iminosugars can lower the GI index by slowing down the degradation of complex carbohydrates in the GI tract.

[0099] Table 2: Fagomine content of commercial rice grains

[0100]

[0101...

Embodiment 3

[0111] Example 3. Rice drink-RiceDream your source of vitality (RiceDreamyour iminosugars in sourceofvitality)

[0112] RiceDream was purchased from Waitrose Supermarket (Hain Europe N.V. Industrielaan 11A, 9990 Maidegem, Belgium Organic 16.03.101 L29-45-075).

[0113] Apply 100ml to the H + Form the cation exchange resin IR120 column (2 × 20cm), and retain the fraction (replaced with 2M ammonia solution) to obtain 15 mg of amino acid fractions containing imino sugars.

[0114] As described below, RiceDream milk analyzed by GC-MS contained 1-deoxynojirimycin (DNJ) with a retention time (11.17 minutes) similar to that of glucose, and had unique fragments with ions at 217, 258, 348 amu (in the tms under condition). Other possible iminosugars were observed at 10.6 minutes (ions 230, 246, 290 and 302 amu) and 11.4 minutes (ions 156, 200 and 217 amu).

[0115] GC-MS

[0116] All samples were lyophilized prior to derivatization. Preparation of trimethylsilane using a mixtur...

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Abstract

The invention provides processes for the production of a composition comprising material derived from seeds of plants of the genus Oryza, the processes comprise the steps of:(a)providing material derived from seeds of the genus Oryza; and(b)determining the presence or absence and / or measuring the amount of at least one iminosugar in the material of step (a). Also described is the use of material derived from seeds of plants of the genus Oryza, which material comprises at least one iminosugar, as a food or feed supplement for lowering the glycaemic index (GI) value of said food or feed.

Description

technical field [0001] The present invention relates to methods of producing rice-based compositions, methods of monitoring rice quality and methods of selection, breeding, identification and screening of rice strains and varieties that have utility in the treatment of energy utilization diseases. Background technique [0002] Rice is the seed of the monocot Oryza sativa (Oryza sativa) (Asian rice) or Oryza glaberrima (African rice). There are four main types of rice: indica (indica) (non-sticky, long-grained); japonica (japonica) (sticky, short-grained); and aromatic (medium long grain), and glutinous (also known as sticky rice) with opaque grains. [0003] Varieties of basmati rice include: basmati, jasmine and wild pecan rice. When steamed, rice grains have a light and fluffy texture. Basmati rice is fragrant rice grown in India and Pakistan. It has a nutty taste and is creamy. It is considered long-grain white rice and is lower in starch than other varieties. Like ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445C07D211/46A01H1/04A01H5/10
CPCA01H1/04A01H5/10A61K31/445A61K36/889A61K8/60A61Q19/00A23L33/105G01N33/10A61K8/9794A61P1/00A61P1/14A61P1/16A61P13/12A61P15/08A61P17/00A61P19/02A61P19/10A61P25/02A61P27/02A61P27/12A61P3/00A61P3/04A61P3/06A61P3/08A61P9/00A61P9/10A61P9/12A61P3/10A01H6/4636A23L7/10G01N30/7206A23V2200/33A23V2002/00A23V2200/328A23L2/52A61K36/899
Inventor 罗伯特·詹姆斯·纳什
Owner PHYTOQUEST
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