Unlock instant, AI-driven research and patent intelligence for your innovation.

Penicillamine nasal gel and preparation method thereof

A technology of nasal gel and penicillamine, which is applied in the field of preparation of nasal gel, can solve the problems of patients’ troubles and reduce the drug absorption rate, and achieve simple and easy method, good temperature sensitivity and biocompatibility, The effect of good histocompatibility

Active Publication Date: 2016-05-04
NORTHEASTERN UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the nasal drops in clinical application are liquid preparations, which are easy to flow into the oral cavity from the nasal cavity during use, which often brings unnecessary troubles to patients and reduces the absorption rate of drugs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Penicillamine nasal gel and preparation method thereof
  • Penicillamine nasal gel and preparation method thereof
  • Penicillamine nasal gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A penicillamine nasal gel is made from the following raw materials in percentage by weight: 0.2% penicillamine, 3% chitosan, 4% sodium beta-glycerophosphate, 0.5% acid solution, and 92.3% deionized water. The penicillamine nasal gel has a pH value of 7.4 and is a colorless to white transparent gel.

[0030] The acid solution is a mixed solution of acetic acid and hydrochloric acid, and the concentrations of the two in the mixed solution are 17.5mol / L and 12mol / L respectively.

[0031] The preparation method of described penicillamine nasal gel is carried out according to the following processing steps:

[0032] (1) Dissolve D-penicillamine in the acid solution at room temperature according to the mass percentage, and stir until completely dissolved;

[0033] (2) Add chitosan and stir to dissolve, and control the stirring speed to 1000r / min;

[0034] (3) Control the temperature at 0~4°C, and keep stirring for 60 minutes;

[0035] (4) Add β-sodium glycerophosphate, sti...

Embodiment 2

[0037] A penicillamine nasal gel is made from the following raw materials in percentage by weight: 0.5% penicillamine, 2% chitosan, 6% sodium beta-glycerophosphate, 0.5% acid solution, and 91% deionized water. The penicillamine nasal gel has a pH value of 7.4 and is a colorless to white transparent gel.

[0038] The acid solution is a mixed solution of acetic acid and hydrochloric acid, and the concentrations of the two in the mixed solution are 17.5mol / L and 12mol / L respectively.

[0039]The preparation method of described penicillamine nasal gel is carried out according to the following processing steps:

[0040] (1) Dissolve D-penicillamine in the acid solution at room temperature according to the mass percentage, and stir until completely dissolved;

[0041] (2) Add chitosan and stir to dissolve, and control the stirring speed to 500r / min;

[0042] (3) Control the temperature at 0~4°C and keep stirring for 40 minutes;

[0043] (4) Add β-sodium glycerophosphate, stir at ...

Embodiment 3

[0045] A penicillamine nasal gel is made from the following raw materials in percentage by weight: 0.8% penicillamine, 5% chitosan, 8% sodium beta-glycerophosphate, 0.2% acid solution, and 86% deionized water. The penicillamine nasal gel has a pH value of 7.4 and is a colorless to white transparent gel.

[0046] The acid solution is a mixed solution of acetic acid and hydrochloric acid, and the concentrations of the two in the mixed solution are 17.5mol / L and 12mol / L respectively.

[0047] The preparation method of described penicillamine nasal gel is carried out according to the following processing steps:

[0048] (1) Dissolve D-penicillamine in the acid solution at room temperature according to the mass percentage, and stir until completely dissolved;

[0049] (2) Add chitosan and stir to dissolve, and control the stirring speed to 600r / min;

[0050] (3) Control the temperature at 0~4°C, and keep stirring for 30 minutes;

[0051] (4) Add β-sodium glycerophosphate, stir a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a penicillamine nasal gel and a preparation method thereof. The nasal gel is prepared from the following raw materials in percent by weight: 0.1-1% of penicillamine, 1-5% of chitosan, 2-8% of beta-sodium glycerophosphate, 0.05-0.5% of acid solution and 85-98% of deionized water. The preparation method comprises the following steps: (1) dissolving D-penicillamine in the acid solution at room temperature according to the percent by weight, and stirring until D-penicillamine is completely dissolved; (2) adding chitosan and stirring for dissolving, wherein the stirring rate is controlled to be 200-1000r / min; (3) controlling the temperature to be 0-4 DEG C, insulating and stirring for 30-60min; and (4) adding beta-sodium glycerophosphate, and stirring for 10-40min at 0-4 DEG C to obtain the penicillamine nasal gel, wherein the stirring rate is controlled to be 100-800r / min. The penicillamine nasal gel provided by the invention has the curative effects of reducing age pigments and treating Alzheimer's disease in animal model tests.

Description

technical field [0001] The invention relates to the preparation of a nasal gel, in particular to a penicillamine nasal gel and a preparation method thereof. Background technique [0002] Alzheimer's disease (Alzheimerdisease, AD) is a degenerative disease of the central nervous system with an insidious onset and a chronic progressive course. It is the most common type of senile dementia. The main manifestations are neuropsychiatric symptoms such as progressive memory impairment, cognitive dysfunction, personality changes, and language barriers, which seriously affect social, occupational, and life functions. With the aging of the population, the incidence of AD is increasing year by year. Prevalence studies show that the percentage of Alzheimer's disease patients will increase by 2 times for every 5 years of age increase. [1] . Patients with advanced AD cannot take care of themselves, which brings heavy pain and burden to patients, families and society. At present, the et...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/198A61K47/36A61K47/24A61P25/28A61P17/00
CPCA61K9/0043A61K9/06A61K31/198A61K47/24A61K47/36
Inventor 高慧玲郭静文王占友王璞
Owner NORTHEASTERN UNIV