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Potassium-supplement injection for reducing vascular irritation

An irritating and injection technology, applied in the direction of inorganic active ingredients, organic active ingredients, medical preparations containing active ingredients, etc., can solve the problems of pain and elevation at the puncture site

Inactive Publication Date: 2016-05-11
LIAONING YAOLIAN PHARMA
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Problems solved by technology

In addition, it can still cause nerve mediators in the body, such as adrenaline, 5-hydroxytryptamine and other substances to increase to varying degrees, resulting in pain at the puncture site

Method used

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  • Potassium-supplement injection for reducing vascular irritation

Examples

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Comparison scheme
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preparation example Construction

[0030] Preparation of sensitized serum: 12 healthy rats were randomly divided into 4 groups, 3 rats in each group, respectively normal saline blank control group, potassium aspartate injection low dose group (107 mg·kg -1 ), high-dose group of potassium aspartate injection (214mg·kg -1 ), ovalbumin positive control group. On the first day, the rats in each group were given corresponding drugs, normal saline and ovalbumin solution respectively by tail vein, and at the same time, intraperitoneal injection of pertussis vaccine (only once), each 1.5ml, sensitization once every other day, 3 times in a row, the last sensitization After 12 days, blood was collected from the orbital venous plexus of rats in each group, and the blood was collected at 2000r·min -1 Serum was separated by centrifugation for 10 min, and stored in a -20°C refrigerator for later use.

[0031] Provocation test: Another 24 healthy rats were randomly divided into 4 groups, 6 in each group. Before the test, t...

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Abstract

The invention discloses a potassium-supplement injection for reducing vascular irritation and a preparation method thereof. The potassium-supplement injection comprises a potassium salt as a drug active component and edetate and injection water as accessory materials. A use amount of the edetate is in a range of 0.01-0.1%(W / V). A rabbit ear vein blood vessel irritation test proves that the potassium-supplement injection can effectively reduce potassium ion-caused irritation on a blood vessel, is beneficial for clinical application and provides a fast potassium-supplement preparation with high compliance for patients with oral administration difficulty.

Description

technical field [0001] The invention relates to a potassium-supplementing injection for reducing vascular irritation, in particular to a low-irritation injection for injecting into the body composed of active ingredient potassium salt and auxiliary materials and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Potassium (K) is the main cation of intracellular fluid, 98% of potassium in the body exists in cells, and K is an important component for maintaining intracellular osmotic pressure. Both myocardium and neuromuscular require a relatively constant K concentration to maintain normal excitability. The normal value of serum K concentration is 3.5-5.0mEq / L. There are various clinical symptoms when K is deficient, but the symptoms appear only when the serum K concentration drops below 3.0mEq / L. Usually the main complaints are fatigue, muscle pain, and weakness of lower limbs. However, severe hypokemia can di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K33/14A61K31/198A61K31/194A61K9/08A61P3/12
Inventor 毕洪书梁胜男
Owner LIAONING YAOLIAN PHARMA
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