Application of atractylenolide in preparation of antidepressant drug

A kind of Atractylodes lactone and anti-depressant technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., to achieve the effects of good protective activity, shortened immobility time, and easy operation
CN105582006AActive Publication Date: 2016-05-18SHANXI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANXI UNIV
Publication Date
2016-05-18

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Abstract

The invention provides application of atractylenolide in preparation of an antidepressant drug, and relates to the field of medicine. In-vitro activity tests prove that atractylenolide I and atractylenolide III have the better protection activity on corticosterone-damaged PC12 cells, and the mechanism is related to inhibition of neuron apoptosis; in-vivo test results show that atractylenolide I and atractylenolide III can significantly shorten the immobility time of a mouse forced swimming test and a mouse tail suspension test. Experiments prove that atractylenolide I and atractylenolide III have the significant antidepressant effect and can be used for preparing the drug for preventing and treating a depressive disorder.
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Description

Technical field:

[0001] The present invention relates to the application of atractylodes lactone, in particular to the application of atractylodes lactone in the preparation of antidepressant drugs. Background technique:

[0002] Depression is characterized by persistent low mood and cognitive dysfunction, including restlessness, anhedonia, sleep disturbance, guilt and repeated suicidal thoughts, etc. Disabling rate and high fatality rate and so on. The World Health Organization reports that more than 350 million people worldwide suffer from depression, and by 2020 depression may become the second leading disease after heart disease. With the rapid development of social economy, the pace of life is accelerated, people's pressure increases, and various emotional impacts increase, resulting in an increase in the incidence of depression year by year. Depression is called "the epidemic of the 21st century", and its harm has attracted more and more attention from the medical an...

Claims

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