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Preparation method of Lindera reflexa Hemsl. general flavones

A technology of total flavonoids and kale, which is applied in the field of natural medicines to achieve great economic and social benefits, good quality, and high product yields

Inactive Publication Date: 2016-06-08
鲁艳清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The total flavonoids of Shanxie have the effect of treating chronic gastritis and gastric ulcer, but there is no preparation method of total flavonoids of Shanxie. How to establish an efficient and convenient extraction and enrichment method that is in line with the characteristics of clinical medication is the key point of the chemical research of natural medicine in traditional Chinese medicine. The key, the present invention adopts modern macroporous adsorption resin enrichment technology to prepare total flavonoids

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] In concrete implementation, the present invention is realized by the following steps:

[0016] (1) Preparation of sample solution: Grind 1kg of the dried medicinal material of Rhizoma chinensis, add ethanol solution and heat to reflux for extraction twice, each time for reflux extraction for 1 hour, the first time with 10L of ethanol, and the second time add 8L of ethanol to the dregs , combine the two extracts, filter and concentrate, add water to disperse, which is the sample solution;

[0017] (2) Resin pretreatment: The method is to soak the D101 macroporous adsorption resin in ethanol with a volume concentration of 95% for 24 hours, then wet-pack the column, and dynamically clean the resin with ethanol with a volume concentration of 95%. 5 times the volume of the resin, washed with water until there is no alcohol smell, soaked in hydrochloric acid with a volume concentration of 5% for 6 hours, and dynamically cleaned the resin. The amount of hydrochloric acid added...

Embodiment 2

[0021] The present invention is realized by the following steps:

[0022] (1) Preparation of sample solution: Grind 1kg of the dried medicinal material of Rhizoma chinensis, add ethanol solution and heat to reflux for extraction twice, each time for reflux extraction for 1 hour, the first time with 10L of ethanol, and the second time add 8L of ethanol to the dregs , combine the two extracts, filter and concentrate, add water to disperse, which is the sample solution;

[0023] (2) Resin pretreatment: The method is to soak the D101 macroporous adsorption resin in ethanol with a volume concentration of 95% for 24 hours, then wet-pack the column, and dynamically clean the resin with ethanol with a volume concentration of 95%. 5 times the volume of the resin, washed with water until there is no alcohol smell, soaked in hydrochloric acid with a volume concentration of 5% for 6 hours, and dynamically cleaned the resin. The amount of hydrochloric acid added was 3 times the volume of t...

Embodiment 3

[0027] The present invention is realized by the following steps:

[0028] (1) Preparation of sample solution: Grind 1kg of the dried medicinal material of Rhizoma chinensis, add ethanol solution and heat to reflux for extraction twice, each time for reflux extraction for 1 hour, the first time with 10L of ethanol, and the second time add 8L of ethanol to the dregs , combine the two extracts, filter and concentrate, add water to disperse, which is the sample solution;

[0029] (2) Resin pretreatment: The method is to soak the D101 macroporous adsorption resin in ethanol with a volume concentration of 95% for 24 hours, then wet-pack the column, and dynamically clean the resin with ethanol with a volume concentration of 95%. 5 times the volume of the resin, washed with water until there is no alcohol smell, then soaked in hydrochloric acid with a volume concentration of 5% for 6 hours, and dynamically cleaned the resin. Soak in lye with a volume concentration of 3% for 6 hours i...

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Abstract

The invention discloses a novel method used for preparing general flavones from the root of Lauraceae Lindera plant Lindera reflexa Hemsl.. The novel method comprises following steps: Lindera reflexa Hemsl. is extracted with ethanol, an obtained extract is recycled and concentrated, and is dispersed in water; impurities are absorbed using a macroporous resin column; solvents are recycled, and an obtained product is delivered through a macroporous resin column again; ethanol or methanol is used for elution; an obtained eluent is subjected to decolouring with active carbon, and then is concentrated and dried so as to obtain the Lindera reflexa Hemsl. general flavones. Technology of the novel method is simple; cost is low; no pollution is caused; the novel method is advanced and safe, and possesses excellent applicability; the extracted Lindera reflexa Hemsl. general flavones can be used for preparing drugs used for treating gastric ulcer and analgesic anti-inflammatory drugs; phamaceutical value of Lindera reflexa Hemsl. is increased; and the novel method is an innovation in the field of drugs.

Description

technical field [0001] The invention provides a new method for preparing total flavonoids from the root of the plant of the genus Lauraceae, the genus Piper. It belongs to the technical field of natural medicines. Background technique [0002] Linderareflexa Hemsl. is a plant of the genus Lauraceae, which is a shrub or a small tree. It is mainly distributed in Henan (Dabie Mountain, Tongbai Mountain and the southern part of Funiu Mountain), Jiangsu, Anhui and other places, and Xinyang area of ​​Henan Province is the most widely distributed and rich in yield, and is the main producing area of ​​Shanxi. The root or bark of the root or root bark is used as medicine. It is warm in nature and pungent in taste. It has the functions of promoting qi and relieving pain, invigorating the spleen and eliminating accumulation, promoting blood circulation and reducing swelling, etc., and the long-term clinical application of the root has achieved good results. It has been used to treat ...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61P1/04
Inventor 鲁艳清张华
Owner 鲁艳清
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