Unlock instant, AI-driven research and patent intelligence for your innovation.

Isosorbide mononitrate osmotic pump tablets capable of completely releasing medicine and preparation method of tablets

A technology of isosorbide dinitrate and osmotic pump tablets, which is applied in the direction of pill delivery, sugar-coated pills, drug combinations, etc., can solve the problem of incomplete release of isosorbide mononitrate single-chamber osmotic pump tablets, increase the cumulative release of drugs, reduce the Drug residues, etc.

Inactive Publication Date: 2016-06-15
CHINA PHARM UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problem of incomplete release of isosorbide mononitrate single-chamber osmotic pump tablet, the present invention relates to a new single-chamber osmotic pump tablet of isosorbide mononitrate. One is a penetration enhancer in the form of 80-100 mesh powder, which provides osmotic pressure for the initial stage of drug release, and the other is a pulse-released pellet form of penetration enhancer. The penetration enhancer pellets have release hysteresis The osmotic pressure difference is replenished in the later stage of pump tablet release, thereby increasing the cumulative release of the drug to about 96%, and significantly reducing the residual amount of the drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Isosorbide mononitrate osmotic pump tablets capable of completely releasing medicine and preparation method of tablets
  • Isosorbide mononitrate osmotic pump tablets capable of completely releasing medicine and preparation method of tablets
  • Isosorbide mononitrate osmotic pump tablets capable of completely releasing medicine and preparation method of tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1 Prescription of pulse-released penetration enhancer pellets (based on 1000 osmotic pump tablets)

[0034] Penetration enhancer pellet core:

[0035] Glucose (80-100 mesh powder form) 8.8g

[0036] Microcrystalline cellulose 3.77g

[0037] Organic acid layer of pulse-released penetration enhancer pellets:

[0038]

[0039] Delayed layer of pulse-released penetration enhancer beads:

[0040]

[0041] Preparation process of pulse-released penetration enhancer pellets:

[0042] Weigh powdered glucose of 80-100 mesh and pass through 80 mesh sieve microcrystalline cellulose, pass through 60 mesh sieve and mix, add water to make soft material, prepare pellets with extrusion spheronizer, dry at 40°C for 12h, use 24-30 mesh sieves to obtain 24-30 mesh pellets; dissolve the acid layer materials sodium acetate and hydroxypropyl methylcellulose in 80% ethanol / water, and use a fluidized bed to coat the pellets in the inner layer ; Add the pellets lagging layer talcum po...

Embodiment 2

[0051] 1 Prescription of pulse-released penetration enhancer pellets (based on 1000 osmotic pump tablets)

[0052] Penetration enhancer pellet core composition:

[0053] Glucose (80-100 mesh powder form) 8.6g

[0054] Microcrystalline cellulose 3.77g

[0055] Organic acid layer of pulse-released penetration enhancer pellets:

[0056]

[0057]

[0058] Delayed layer of pulse-released penetration enhancer beads:

[0059]

[0060] The preparation process of the pulse-released penetration enhancer pellets is the same as the preparation process of the pulse-released penetration enhancer pellets in Example 1.

[0061] 2 prescriptions for osmotic pump tablets (based on 1000 osmotic pump tablets)

[0062] Chip composition:

[0063]

[0064] Semipermeable Membrane for Tablet Core Coating:

[0065]

[0066] The preparation process of the osmotic pump tablet is the same as the preparation process of the osmotic pump tablet in Example 1.

Embodiment 3

[0068] 1 Prescription of pulse-released penetration enhancer pellets (based on 1000 osmotic pump tablets)

[0069] Penetration enhancer pellet core composition:

[0070] Glucose (80-100 mesh powder form) 8.4g

[0071] Microcrystalline cellulose 3.77g

[0072] Organic acid layer of pulse-released penetration enhancer pellets:

[0073]

[0074]

[0075] Delayed layer of pulse-released penetration enhancer beads:

[0076]

[0077] The preparation process of the pulse-released penetration enhancer pellets is the same as the preparation process of the pulse-released penetration enhancer pellets in Example 1.

[0078] 2 prescriptions for osmotic pump tablets (based on 1000 osmotic pump tablets)

[0079] Chip composition:

[0080]

[0081] Semipermeable Membrane for Tablet Core Coating:

[0082]

[0083] The preparation process of the osmotic pump tablet is the same as the preparation process of the osmotic pump tablet in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of pharmaceutical preparations and particularly relates to isosorbide mononitrate osmotic pump tablets capable of completely releasing medicine and a preparation method of the tablets. A penetration enhancer in tablet cores has two existence forms, including a penetration enhancer in the form of powder 80-100 meshes and pulse release penetration enhancer in the form of pellets. Pulse release penetration enhance pellets have certain time lag, are mixed with main medicine granules for tableting and then are coated with a film coat material containing a pore-forming agent. The penetration enhancer in the form of powder supplies osmotic pressure in the early period of medicine release while the pulse release penetration enhance pellets supply osmotic pressure in the later period of medicine release, and the final accumulated medicine release amount can reach 96%. The invention further relates to formulation technology preparation methods of the pulse release penetration enhance pellets and the osmotic pump tablets. The prepared osmotic pump tablets capable of completely releasing the medicine are good in medicine release linearity, small in blood concentration fluctuation and good in patient compliance.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to an isosorbide mononitrate osmotic pump tablet preparation for treating coronary heart disease and preventing angina pectoris and a preparation method thereof. Background technique [0002] Isosorbide mononitrate is one of the commonly used cardiovascular drugs in clinical practice. It releases a highly active endothelial relaxation factor (NO) in the body, which can effectively dilate veins, increase venous capacity, reduce blood return to the heart, and reduce heart failure. Preload, while dilating peripheral arteries and arterioles, reduces systemic vascular resistance, reduces cardiac preload, thereby reducing myocardial oxygen consumption. Isosorbide mononitrate in the patient's body is eventually denitrified, and most of it is excreted through the kidneys through the urine without accumulation. It is an ideal nitrate drug. [0003] The earliest isosorbide mononitr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/24A61K9/28A61K31/34A61P9/10
CPCA61K9/2059A61K9/2866A61K31/34
Inventor 王柏彭杰
Owner CHINA PHARM UNIV