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Production technology for synthesizing fluorouracil with one-step method

A technology for fluorouracil and production process, which is applied in the field of one-step synthesis of 5-fluorouracil, can solve the problems of high price of fluorine gas, and achieve the effects of cost saving and process simplification

Inactive Publication Date: 2016-06-22
江苏梅兰化工有限公司
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Problems solved by technology

The direct fluorination method uses uracil as a raw material, and reacts with fluorine diluted with nitrogen to obtain 5-fluorouracil through simple treatment. Synthetic process

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  • Production technology for synthesizing fluorouracil with one-step method

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Embodiment Construction

[0008] The production process of the invention comprises: a fluorination reaction unit, an AHF recovery unit, a purification unit, a neutralization unit, a decolorization unit, a crystallization separation unit, a drying unit and a weighing and packaging unit.

[0009] The specific technical process of the present invention is: a production process for synthesizing 5-fluorouracil by one-step method, which includes the following steps: under the protection of an inert gas, uracil uses anhydrous hydrogen fluoride as a reaction solvent and a dehalogenating agent, and fluorines the uracil with fluorine gas After post-treatment, 5-fluorouracil can be obtained. Fluorination can be carried out well by passing hydrofluoric acid during the reaction process. The fluorination reaction is carried out at a temperature of -20-50°C and a pressure of 0-0.5Mpa. Uracil is dissolved in AHF, and fluorine gas is introduced into the reaction to generate 5-fluorouracil. The container of the fluorina...

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Abstract

The invention discloses a production technology for synthesizing fluorouracil with a one-step method. The production technology adopts a fluoridation unit, an AHF (anhydrous hydrogen fluoride) recovery unit, a purification unit, a neutralizing unit, a decolorization unit, a crystallization and separation unit, a drying unit and a weighing and packaging unit. The production technology has the advantages that the process is short, a little equipment investment is needed, the product yield is high, a product contains a few impurities and is good in quality, no waste catalyst is produced, HF (hydrogen fluoride), a solvent and mother liquor are recycled, the requirement of circular economy is met, and the economic benefit is quite obvious.

Description

technical field [0001] The invention relates to a production process for synthesizing 5-fluorouracil in one step. Background technique [0002] 5-Fluorouracil (C4H3FN2O2) is an important antitumor drug and a key intermediate in the synthesis of fluoropyrimidine antitumor drugs. There are currently three production methods; 1. Direct synthesis. 2. Condensation and cyclization method. 3. Condensation method of ethyl fluoroacetate and ethyl formate. The direct fluorination method uses uracil as a raw material, and reacts with fluorine diluted with nitrogen to obtain 5-fluorouracil through simple treatment. Synthetic process. With the mature, safe and reliable operation of the electrolytic fluorine production process, fluorine gas is no longer a bottle shank for direct synthesis of 5-fluorouracil. Contents of the invention [0003] The invention provides a production process for synthesizing 5-fluorouracil by one-step method, which not only has a short process flow, less ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/553
CPCC07D239/553
Inventor 王卫国孙忠英陈明柳存林
Owner 江苏梅兰化工有限公司