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Silymarin extraction method

A technology of silymarin and extraction method, which is applied in the field of extraction of silymarin, can solve the problems of reduced content of active ingredients, long production cycle, complicated operation, etc., and achieves the effects of not being easy to oxidize, deteriorate and change color, promoting dissolution balance, and simple extraction method

Inactive Publication Date: 2016-06-22
河南智晶生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, under the conditions of organic solvent leaching, there are also studies on the extraction of silymarin by Soxhlet extraction and ultrasonic extraction, but these methods generally have complex operations, high energy consumption, long production cycle, low yield, and large amounts of organic waste. liquid etc.
The extraction of silymarin by alkali extraction and acid precipitation will easily lead to changes in the structure of silybin, resulting in a decrease in the content of active ingredients and an increase in impurities in the extract, so it is not suitable for use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The present embodiment provides a method for extracting silymarin, comprising the following steps:

[0023] (1) Rough extraction: put oil-free milk thistle seeds and 8 times the amount of methanol of the oil-free milk thistle seeds into an extraction container, which is a stainless steel drum with a diameter of 20 cm and a height of 40 cm ; under the condition of 25 degrees Celsius, the inner and outer double blades are used to cut and break the oil-free milk thistle seeds, and the inner blade and the outer blade maintain a distance of 0.5 mm to 1.0 mm, and the inner blade is at the same time 1.5×10 4 The speed of revolution per minute rotates around its center to cut and stir the oil-free milk thistle seeds in the extraction container to form the broken oil-free milk thistle seeds with a particle size of 40-60 mesh, and produce about 0.4 The vortex negative pressure of MPa makes the silymarin extract ooze out rapidly from the broken oil-free milk thistle seed cells an...

Embodiment 2

[0028] The present embodiment provides a method for extracting silymarin, comprising the following steps:

[0029] (1) Rough extraction: the specific implementation of this step in this example is basically the same as that of the crude extraction in Example 1, the difference being that the amount of methanol added is 14 times the amount of the oil-free water fly Thistle seeds, said inner blade spins at 2×10 4 rpm, and generate a vortex negative pressure of about 0.45 MPa;

[0030] (2) Concentration of the crude extraction filtrate: the specific implementation of this step in this embodiment is the same as that of the concentration of the crude extraction filtrate in Example 1;

[0031](3) Fine extraction: the specific implementation of this step in this example is basically the same as that of the fine extraction in Example 1, the difference being that the amount of pure water added is 18 times the amount of total extraction of silymarin things.

[0032] The total yield of...

Embodiment 3

[0034] The present embodiment provides a method for extracting silymarin, comprising the following steps:

[0035] (1) Rough extraction: the specific implementation of this step in this example is basically the same as that of the crude extraction in Example 1, the difference being that the amount of methanol added is 20 times the amount of the oil-free water fly Thistle seeds, said inner blade spins at 2.5×10 4 rpm, and generate a vortex negative pressure of about 0.5 MPa;

[0036] (2) Concentration of the crude extraction filtrate: the specific implementation of this step in this embodiment is the same as that of the concentration of the crude extraction filtrate in Example 1;

[0037] (3) Fine extraction: the specific implementation of this step in this example is basically the same as that of the fine extraction in Example 1, the difference being that the amount of pure water added is 16 times the amount of the total extraction of silymarin things.

[0038] The total yi...

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Abstract

The invention provides a silymarin extraction method. The method comprises the following steps: 1, carrying out crude extraction: placing greaseless milk thistle seeds and an organic solvent in an extraction container, cutting and stirring the greaseless milk thistle seeds to break the greaseless milk thistle seeds and form a negative pressure in order to make a silymarin extract product rapidly ooze out of cells of the greaseless milk thistle seeds and be uniformly dispersed in the organic solvent, and filtering to obtain a silymarin crude extract filtrate; 2, concentrating the crude extract filtrate: concentrating the silymarin crude extract filtrate to obtain a silymarin total extract product; and 3, carrying out fine extraction: separating finished silymarin from the silymarin total extract product. The extraction method has the advantages of rapidness, high efficiency, normal temperature extraction, no destroy to effective components of silymarin, energy saving, consumption reduction and simplicity.

Description

technical field [0001] The invention relates to an extraction method for extracting silymarin from plant milk thistle. Background technique [0002] Milk thistle (Silybum Marianum Gaertn), or milk thistle (Milk Thistle), artichoke (Artichoke), is native to India and Pakistan, and then cultivated in many regions in Europe, America and Australia. Introduced to my country from Germany in 1972, it is now widely cultivated in Northeast China, Shaanxi and other places. The achene of milk thistle is long oval or obovate, the surface color is light brown to dark brown, with linear dark brown spots. Milk thistle seeds contain about 26% oil, and also contain a lot of flavonoids that are insoluble in water, mainly silymarin. Silymarin is a mixture of flavonoids and lignin compounds, including silybin, dehydrosilybin, polysilybinomer, isosilybin ), silychristin, silydianin and other compounds, among which silybin is the main active ingredient with the highest content. [0003] Silyb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/04
Inventor 李月梅卢付军李开言
Owner 河南智晶生物科技股份有限公司
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