38 results about "Silyamandin" patented technology

The invention relates to the technical field of biology, in particular to silymarin inclusion compound lipidosome and a preparation method and application thereof. The silymarin inclusion compound liposome is prepared from the following components in parts by weight: 10 to 48 parts of silymarin, 10 to 53 parts of phospholipid, 5 to 10 parts of Arabic gum and 25 to 70 parts of cyclodextrin. According to the invention, cyclodextrin and phospholipid are combined to form a double-drug-loading structure; on the basis, Arabic gum is used as a film-forming agent to form a protective film on the surface of the liposome, so that the stability of the system is further improved; the silymarin inclusion compound is encapsulated in a water phase in the liposome, and meanwhile, part of free silymarin is encapsulated in a lipid bilayer. According to the structure, the solubility and the encapsulation efficiency of the silymarin are remarkably improved, the liposome stability is enhanced, the drug release is effectively controlled, and the silymarin inclusion compound lipid is simple in preparation process and suitable for industrial production.

The invention relates to a preparation method of a silymarin and pueraria isoflavone composite reagent. The preparation method comprises the following steps: S1, extracting silybin; s2, soaking the roots and stems of the kudzuvine roots; s3, extracting a radix puerariae isoflavone stock solution; s4, concentrating the radix puerariae isoflavone stock solution; s5, extracting a pueraria isoflavone concentrated solution; s6, mixing and granulating; and S7, tabletting and coating to obtain the flaky silymarin and pueraria isoflavone composite reagent. According to the prepared silymarin and pueraria isoflavone composite reagent, the silymarin dry powder and the pueraria isoflavone extract serve as core components, the silymarin dry powder can enhance liver detoxification and repair liver cells, the pueraria isoflavone extract can accelerate alcohol metabolism, and the silymarin dry powder and the pueraria isoflavone extract have a remarkable improvement effect on fatty liver, alcoholic liver and the like under the synergistic effect.

The invention relates to the technical field of plant extracts, in particular to a method for removing pesticide residues in silymarin. According to the method for removing the pesticide residues in the silymarin, the pesticide residues in the silymarin with high pesticide residues can be effectively removed, the removal rate of the pesticide residues is larger than 95%, the total pesticide residues of the silymarin can be effectively reduced, and then a silymarin product with low pesticide residues is prepared; the method has the advantages of simple process, low cost, recoverable solvent and the like, is suitable for industrial production, provides an effective method for industrial production of silymarin with low pesticide residue, and has important significance for improving the safety and application value of silymarin products.

The application discloses a low-residual extractive method of silymarin and a preparation method thereof. The low-residual extractive method of silymarin comprises the following steps: eluting oil and fat; crushing silybum seed, soaking and eluting oil and fat by using n-hexane, and obtaining a soaking solution; adding ethanol into the soaking solution, filtering after standing, adding water into the concentrated filtrate, and taking the lower layer solution and the precipitate; and crystallizing and drying, filtering after crystallizing again, and drying the silymarin crystals. The low-residual extractive method of silymarin provided by the application has the effect of reducing the solvent residue in silymarin.

The invention relates to an application of a silybum marianum extract for improving, preventing or treating fatty liver, wherein the bioavailability of silymarin is improved. In the present invention, a silybum marianum extract of the present invention having improved bioavailability is prepared by subjecting silybum marianum seeds to enzyme treatment and low-concentration ethanol solvent extraction, and it is confirmed that the silybum marianum extract of the present invention has high bioavailability and exhibits excellent efficacy in improving, preventing or treating fatty liver.

The invention relates to the technical field of compound extraction, in particular to a silybum marianum extract and a preparation method thereof. The preparation method of the silybum marianum extract comprises the following steps: S1, carrying out subcritical extraction on a silybum marianum seed shell raw material, and extracting the silybum marianum seed shell raw material subjected to subcritical extraction by adopting an organic solvent to obtain an extracting solution; s2, concentrating the extracting solution until the specific gravity is 0.90 g / ml to 0.99 g / ml, so as to obtain a first concentrated solution; and S3, performing supercritical extraction on the first concentrated solution, and then performing desolvation and drying. The preparation method disclosed by the invention is high in extraction rate, energy-saving, environment-friendly and pollution-free, the obtained silymarin is low in pesticide residue and high in product content, and large-scale, industrial and continuous production of the high-quality silymarin can be realized.

The invention provides a composition for improving the thrombolysis capacity of a human body, a preparation method and application thereof.The composition is prepared from, by weight, 5-30 parts of earthworm protein, 30-120 parts of hippophae rhamnoides total flavone extract, 50-150 parts of silymarin extract, 20-80 parts of maltodextrin and 15-60 parts of pregelatinized starch, the earthworm protein activates a fibrinolytic system to promote t-PA to release and dissolve thrombus, and the hippophae rhamnoides total flavone extract activates the fibrinolytic system to promote t-PA to release and dissolve thrombus; the hippophae rhamnoides total flavonoids regulate the ratio of PGI2 / TXA2 to inhibit platelet aggregation and reduce blood fat, the silymarin protects the liver function to enhance LDL-C metabolism clearing, the hippophae rhamnoides total flavonoids, the silymarin and the hippophae rhamnoides total flavonoids cooperate to form a thrombolysis-antithrombosis-metabolism regulation three-dimensional intervention system, a whole-course low-temperature mixing direct tabletting process is adopted

The invention relates to nutritional products, and discloses a compound nutrient as well as a preparation method and application thereof. The nutrient beverage contains blueberry anthocyanin, silymarin, theanine, algal oil DHA (docosahexaenoic acid) and phosphatidylserine. The method comprises the following steps: (1) mixing a raw material I to obtain a solid mixture; mixing the raw materials II to obtain a liquid mixture; mixing the solid mixture and the liquid mixture; the raw material I contains blueberry anthocyanin, silymarin and theanine, and the raw material II contains algae oil DHA (docosahexaenoic acid) and phosphatidylserine. The compound nutrient has a good blood fat reducing effect, is safe and does not have toxic or side effects.

The application discloses a culture method for enhancing the body color of Eaststar Prawn and relates to the technical field of aquaculture. The method comprises the following steps: (1) light induction: white-red-blue-yellow light sources are alternately used for irradiation, (2) color enhancer feeding: the color enhancer is fed simultaneously with the basic feed, and the components of the color enhancer include Camellia nitidissima polysaccharide, Sargassum fusiforme polysaccharide, fucoxanthin, scallop peptide, silymarin, guanidino acetic acid and sodium butyrate, and (3) water flow stimulation. Through the regulation of physiological metabolism, nutrient absorption and environmental adaptability, the method jointly acts on the body color performance of Eaststar Prawn, is favorable for enhancing the body color of Eaststar Prawn and improving the economic value of Eaststar Prawn.

Cosmetic and dietary supplement compositions containing silymarin and sulfoalkyl ether cyclodextrin, particularly sulfobutyl ether cyclodextrin, are described. The compositions and methods are useful in reducing appearance of facial redness in rosacea-prone skin, rejuvenating skin, preventing skin aging, inhibiting oxidative stress in epidermal and dermal cells, increasing collagen production, reducing the likelihood of skin cancer, treating or reducing liver damage from a toxin, or treating a liver disease.

The invention relates to a novel formulation or composition of krill oil and silymarin and use thereof, in particular for the treatment and prophylaxis of liver diseases.

Disclosed are personal care compositions comprising a carboxymethyl cysteine compound and a silymarin compound wherein the silymarin compound is selected from the group consisting of silymarin, silybin, isosilybin, silymarin, silymarin, silymarin, silymarin, silymarin, neosilymarin, salts and esters thereof, and combinations thereof.

The invention belongs to the field of additives, and discloses a plateau overwintering feed additive for non-plateau chicken breeds, the plateau overwintering feed additive comprises methionine and silymarin; the weight ratio of the methionine to the silymarin is 1: (0.1-0.5). The feed additive contains methionine and silymarin, is used for reducing the death rate of plain commercial chickens during overwintering in the plateau, and can effectively improve the growth performance of the commercial chickens. Another purpose of the invention is to provide application of the additive and feed.

The invention belongs to the field of natural pharmaceutical chemistry and the field of cosmetics, and particularly relates to a skin care composition, a skin care product and application thereof.The skin care composition comprises silymarin, epigallocatechin gallate and quercetin, and the mass ratio of the silymarin to the epigallocatechin gallate to the quercetin is (3-7): (3-10): (1-5). The skin care product comprises the skin care composition, the content of the skin care composition is 0.5-10%, the skin care composition or the skin care product is applied to preparation of the skin care cosmetics, the esterified lecithin is used for encapsulating the silymarin, the epigallocatechin gallate and the quercetin, and sodium hyaluronate is matched, so that the skin care composition or the skin care product can be used for preparing the skin care cosmetics. The problems that flavonoid compounds are difficult to dissolve, permeate and absorb are effectively solved, and meanwhile, the skin care composition and sodium hyaluronate have a synergistic effect, so that the moisturizing, wrinkle removing and aging resisting effects are remarkably improved.

Nutritional supplements and compositions for activating cellular signaling genes in innate inflammatory pathways are described in this application. In particular, this application describes a composition containing a solid portion comprising Bacopa monnieri extract having a least 20 percent bacosides, Silybum marianum (milk thistle) extract having 70 percent to about 80 percent silymarin, milk thistle extract, Withania somnifera (ashwagandha) extract, Camellia sinensis (green tea) extract containing at least 40 percent epigallocatechin gallate and about 98 percent polyphenols; and Curcuma longa (turmeric) extract containing at least about 95 percent curcumin. The compositions also comprise a liquid portion comprising fish collagen peptides comprising about 90 percent protein and Formosa ruby quinoa water extract containing about 10 wt % extract and about 90 wt % water. These compositions improved the skin and impacted key regulatory genes associated with several important cellular pathways. Other embodiments are also described.

The invention discloses a composition for protecting liver functions and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The preparation method comprises the following steps: firstly, treating chrysanthemum in steps, preparing part of chrysanthemum into sterilized fine powder for later use, and adding part of chrysanthemum into an extraction system; the preparation method comprises the following steps: crushing and breaking shells of part of cassia seed and cistanche, mixing with Chinese angelica, performing ethanol percolation extraction, performing secondary water reflux extraction on decoction dregs and other traditional Chinese medicine raw materials, combining percolate and reflux filtrate, and concentrating; synchronously preparing a silybum marianum extract, a Chinese magnoliavine fruit extract and reduced glutathione which meet standards, spray-drying a concentrated solution, adding the chrysanthemum fine powder and the three types of core extracts, and performing three-dimensional mixing to obtain a finished product. The silymarin is used for enhancing liver cell membrane protection, the schisandra chinensis extract is used for activating an endogenous antioxidant system, the reduced glutathione is used for removing toxic substances, the traditional Chinese medicine components are used for synergistic interaction, meanwhile, the process is optimized to guarantee uniform component retention and distribution, and the problems that a traditional preparation is single in effect and unstable in quality are solved.

Provided is a method for improving or regulating liver metabolism level, enhancing or maintaining liver function, improving or maintaining liver health in a subject, which includes administering to the subject an effective amount of tetrahydrocurcumin and silymarin composition. The composition can be widely applied to nutritional supplements, foods and beverages.

The invention provides an ultrasonic extraction method of silymarin, and relates to the technical field of silymarin production. The ultrasonic extraction method of silymarin comprises the following steps: S1, selecting silybum marianum, cleaning and squeezing oil to obtain silybum marianum cake powder; s2, taking organic solvents such as acetone and ethyl acetate as extraction solvents for the silybum marianum cake powder, and applying ultrasonic waves to an extracted substance for extraction to obtain an extracting solution; s3, concentrating the extracting solution to obtain a concentrate flow extract; s4, degreasing the concentrate flow extract to obtain a degreased extract; s5, refining the degreased extract to obtain a refined extract; and S6, carrying out low-pressure and low-temperature drying on the refined extract to form a dry extract, and carrying out intermediate inspection. According to the ultrasonic extraction method for silymarin, the characteristic that silymarin can be rapidly and completely dissolved into an extraction solvent under the action of ultrasonic waves in the extraction solvent is utilized, so that the extraction time is greatly shortened, the production efficiency is improved, the labor intensity is reduced, and the production safety is improved.

The present invention discloses a highly permeable supramolecular preparation of silymarin, its preparation method, and application. The silymarin supramolecular preparation comprises the following components by weight: 1.0 to 8.0 parts of silymarin, 0.1 to 1.0 parts of kava extract, 89.0 to 98.8 parts of a cyclodextrin derivative, and 0.1 to 2.0 parts of a hydrophilic polymer. The preparation method comprises dissolving silymarin and the kava extract in an organic solvent to obtain a yellow transparent solution A; dissolving the cyclodextrin derivative and the hydrophilic polymer in deionized water to obtain a transparent solution B; dropping the yellow transparent solution A into the transparent solution B and stirring uniformly to obtain a light yellow transparent mixed solution C; and spray drying or freeze-drying the light yellow transparent mixed solution C to obtain the silymarin supramolecular preparation. The silymarin supramolecular preparation of the present invention has the characteristics of high permeability and low irritation and can be applied to the cosmetics field to prepare skin care products.

The application aims to establish a solubilization system for improving the dissolution of silymarin and prepare silymarin-loaded polymer microspheres, and belongs to the technical field of pharmaceutical preparations. The silymarin polymer microspheres prepared by the solubilization system can significantly improve the dissolution of silymarin. The method for preparing the silymarin polymer microspheres in the application is as follows: S1: uniformly mixing pre-activated corn starch, nicotinamide and O / W emulsifier in deionized water to form an aqueous phase; S2: dissolving silymarin in ethyl acetate to form an oil phase; S3: slowly adding the oil phase to the aqueous phase and stirring at high speed to prepare an emulsion; S4: placing the emulsion in an ice water bath for several hours, centrifuging, taking the precipitate, and freeze-drying to obtain silymarin microspheres.

The application discloses a kind of compositions for anti-allergic repair and application thereof.The anti-allergic composition includes the following components: 1-5 parts by weight of silk fibroin, 1-5 parts by weight of carrageenan, 40-200 parts by weight of water, 5-15 parts by weight of anti-allergic ingredients, 2-10 parts by weight of silymarin phosphate, 5-15 parts by weight of repair ingredients, 0.2-0.8 parts by weight of gamma-polyglutamic acid, and 0.2-1 parts by weight of polyethylene glycol-20000.The application also provides a preparation method thereof.Compared with the prior art, the anti-allergic repair composition prepared by the application can reduce the permeability of capillary vessels, has good inhibition of hyaluronidase, and has good anti-allergic repair effect.The anti-allergic repair composition prepared by the application can also be applied in face masks, face creams and dressings.

The invention relates to the field of medical instruments, the field of medical or dressing preparations, the technical field of biological medicine manufacturing and the technical field of preparation, in particular to a supramolecular anti-aging composition suitable for people with sensitive skin and a preparation method and application of the supramolecular anti-aging composition. Active ingredients, an inclusion material, an emulsifier and a solvent; the active ingredients are prepared from silymarin, silanetriol and phytol; the silymarin comprises silibinin, silymarin and silymarin; the silymarin comprises silybin, silymarin and silymarin; the inclusion material comprises at least one of hydroxypropyl-alpha-cyclodextrin and hydroxypropyl-beta-cyclodextrin, and the inclusion material comprises at least one of hydroxypropyl-alpha-cyclodextrin and hydroxypropyl-beta-cyclodextrin; the emulsifying agent is prepared from at least one of oleyl alcohol polyether-20, Tween 80 and PPG-13-decyl tetradecyl alcohol polyether-24; the solvent comprises water and polyhydric alcohol. The composition provided by the invention has excellent anti-aging effect and stability, has a good effect of reducing allergy, and is suitable for sensitive people.

The utility model discloses a cooling device for a silymarin extraction tank, and relates to the technical field of silymarin production equipment. The utility model relates to a cooling device for a silymarin extraction tank, which comprises a cooling jacket and is characterized in that a storage device is arranged in the upper end face of the cooling jacket, and a soaking device for stirring silymarin in the storage device is arranged on the upper end face of the storage device. Cooling devices for assisting in cooling silymarin in the storage device are arranged on the left side wall and the right side wall of the storage device, and heat dissipation devices for improving the cooling effect are arranged on the left side wall and the right side wall of the cooling jacket. The silymarin in the storage device is further cooled through the cooling device, so that the cooling efficiency of the silymarin is improved, and the cooling device cools the cooling end of the cooling device, so that the effect of accelerating the cooling of the silymarin in the storage device by the cooling device is achieved.

This invention belongs to the field of feed additives, and particularly relates to a montmorillonite-co-loaded silymarin nanosuspension and its preparation method. The montmorillonite-co-loaded silymarin nanosuspension comprises montmorillonite, silymarin, liquid phospholipids, and chitosan, wherein silymarin is loaded onto the surface and interlayer of montmorillonite via liquid phospholipids, forming a nano-dispersion system with a particle size distribution of 150–320 nm. The montmorillonite-co-loaded silymarin nanosuspension and its preparation method provided by this invention achieve efficient loading, nano-dispersion, and liver-targeted delivery of silymarin.

The invention relates to the technical field of cosmetics, in particular to a silymarin composition, a transparent aqueous solution and a preparation method of the transparent aqueous solution, the silymarin composition at least comprises silymarin, nicotinamide, hydrophilic polyol and water, and the mass ratio of the silymarin to the nicotinamide to the hydrophilic polyol to the water is 0.05: (2-3): (2.5-5): 2. By optimizing a composition formula system, the dissolution of the silymarin in water is realized, and the silymarin can be stabilized in a transparent aqueous solution product system without additionally adding a specific emulsifier, a solubilizer and the like subsequently, so that the application range of the silymarin is expanded.

The invention relates to a method for preparing silybum marianum from silymarin, which comprises the following steps of: heating the silymarin in an inert atmosphere with the pressure of 15-19 Mpa at the temperature of 140-170 DEG C to obtain a product with high silybum marianum content. The method has the advantages of simple steps, high yield, easy purification of the crude product, and high product purity.

The invention belongs to the technical field of medicines, and particularly relates to a silybum marianum composition for improving liver function and a preparation method thereof, the composition comprises quick-release cholagogic micro powder and slow-release liver-nourishing particles in a mass ratio of 1: (2-4); the quick-release cholagogic micro powder is prepared from curcumin, fructus aurantii immaturus flavone, a tanshinone extract and PVP K30 through ball-milling solid dispersion; the slow-release liver-nourishing particle is of a core-shell structure, a freeze-drying core of the slow-release liver-nourishing particle contains silymarin and schizandrin extract, and a glycyrrhetinic acid-phospholipid / chitosan oligosaccharide targeted coating and a medicinal acrylic resin coating are sequentially arranged on an outer layer of the slow-release liver-nourishing particle. According to the composition, through sequential synergy of'first defibering and then repairing 'and a liver targeting effect, the content of silymarin in liver tissue is remarkably increased, the silymarin is retained for a long time, and liver function impairment such as non-alcoholic fatty liver disease is effectively improved.

This invention relates to a nanoemulsion composition, its preparation method, and its application. The nanoemulsion composition comprises 30 wt% to 88 wt% of oil, 10 wt% to 45 wt% of emulsifier, 1 wt% to 10 wt% of silymarin, and 1 wt% to 20 wt% of retinoids. The emulsifier is selected from polysorbate and polyoxyethylene hydrogenated castor oil, and the LogP value of the oil is less than or equal to 5. The nanoemulsion composition provided by this invention, under the action of a specific emulsifier, simultaneously encapsulates silymarin and retinoids through the oil, effectively improving the solubility and stability of silymarin and retinoids. When added to water, it can self-emulsify to form a stable nanoemulsion system, thereby increasing the content, utilization rate, and skin permeability of silymarin in cosmetics. Simultaneously, the nanoemulsion composition does not contain alcohol or polyols or other co-emulsifiers, has low skin irritation, and is generally applicable to different types of cosmetic systems, showing broad application prospects.

The invention discloses a silymarin solid dispersion, silymarin ophthalmic gel and a preparation method of the silymarin ophthalmic gel. The silymarin ophthalmic gel comprises the following components in parts by weight: 0.1-10 parts of a silymarin solid dispersion, 0.5-20 parts of a gel matrix, 1-80 parts of a preservative, 0.5-10 parts of a humectant and 0.5-2 parts of a buffer agent, and the silymarin solid dispersion is prepared by dispersing silymarin and analogues thereof in a hydrophilic carrier material through a melting method. The solubility of silymarin and analogues thereof is improved through a solid dispersion technology, the problem of poor stability of silymarin and analogues thereof is solved, the bioavailability of the silymarin and analogues thereof in local eye application is improved, and the prepared eye gel product can effectively eliminate oxygen free radicals on the eye surface, inhibit lipid peroxidation and increase the content of superoxide dismutase so as to delay senescence. The preparation process is simple, large-scale production is easy, the residence time of the medicine in eyes is prolonged, the bioavailability is improved, and meanwhile the medication compliance of a patient is improved.

The invention provides a nutrient for improving the activity of hepatocyte regeneration peptide, and belongs to the technical field of livestock and poultry breeding and animal health-care products, and the nutrient comprises the following components by mass: 20 g of polypeptide extracted from animal liver; 2g of vitamin B; 5 g of glycyrrhizic acid; and 6 g of silybum marianum. Through the synergistic effect of multiple components, the small molecule peptide extracted from the animal liver directly promotes liver cell regeneration in a targeted mode, the vitamin B2 strengthens the liver metabolism function, the beta-diammonium glycyrrhizinate efficiently resists inflammation and detoxifies, the silymarin extract accurately removes mycotoxin, and a complete protection chain of regeneration repair, metabolism enhancement, inflammation inhibition and toxin removal is formed; basic problems such as liver injury and metabolic disorder can be handled, complex diseases such as continuous endotoxin injury and mycotoxin accumulation which are difficult to overcome in the prior art can be solved, and the defect that the effect of a single-component product is limited is overcome.