Passive sampling instrument for measuring macrolide antibiotic in water and application thereof

A technology of macrocyclic lactones and passive samplers, which is applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems of expensive production cost, cumbersome operation, complex structure, etc., and achieve convenient transportation and storage, simple cleaning, and small volume. small effect

Active Publication Date: 2016-06-22
NANJING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to overcome the characteristics of complex structure, expensive manufacturing cost and cumbersome operation of the passive sampler used for antibiotics in water in the prior art, and to provide a method for measuring the content of macrolide antibiotics in water currently. Passive sampler for the determination of macrolide antibiotics in water and its application

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  • Passive sampling instrument for measuring macrolide antibiotic in water and application thereof
  • Passive sampling instrument for measuring macrolide antibiotic in water and application thereof
  • Passive sampling instrument for measuring macrolide antibiotic in water and application thereof

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Embodiment 1

[0042] combine figure 1 As shown, a kind of passive sampler that is used to measure the antibiotic in the water body in the present embodiment, internal diameter and height are the sampling barrel of the stainless steel band lid of 2-4cm, and the sampling barrel is made by 100 order stainless steel wire meshes, is equipped with 1g The granular XAD-18 resin is used as the adsorbent, and the adsorbent can be selected as the granular XAD-4 resin according to actual needs, and the particle size of the adsorbent is 20-60 mesh.

[0043] A kind of passive sampler for measuring macrolide antibiotics in the present embodiment and the specific sampling determination method of its application are as follows:

[0044] i) Cleaning of adsorbent:

[0045] Before sampling, the granular XAD-18 resin adsorbent was washed with pure water and methanol in sequence, then baked in an oven at 65°C for 2 hours, and stored in a brown glass bottle after cooling.

[0046] ii) Sampling process:

[0047...

Embodiment 2

[0062] The basic structure of a kind of passive sampler used for macrolide antibiotics in water body and its application of the present embodiment is the same as embodiment 1, select another water body to carry out passive sampling, through continuous sampling for 7 days, calculate according to formula 2 Average concentration of macrolide antibiotics C w see table 1

[0063] The concentration of five kinds of antibiotics in the river in table 1 embodiment 1 and embodiment 2

[0064]

[0065] In summary, a passive sampler for macrolide antibiotics in water bodies of the present invention is simple to manufacture and assemble, and low in price, and the extraction of macrolide antibiotics in the adsorbent only needs a simple process. The solvent elution is completed, which greatly reduces the use of organic solvents and shortens the analysis time. It is suitable for the passive sampling and monitoring of macrolide antibiotics in the water environment, and has a good applicati...

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Abstract

The invention discloses a passive sampling instrument for measuring macrolide antibiotics in water and application thereof and belongs to the field of antibiotic sampling and measuring.The passive sampling instrument comprises a sampling barrel and adsorbent, wherein the sampling barrel is made of a 100-mesh stainless steel screen, and the sampling barrel is filled with granular XAD resin.A sampling and measuring method mainly comprises the steps of adsorbent cleaning, sampling, extracting of antibiotics in the adsorbent, antibiotic content measuring through HPLC-MS / MS, sampling rate measuring and time weighed mean concentration Cw calculation of antibiotics in the water.The passive sampling instrument is easy to manufacture and assemble and low in cost, extracting of macrolide antibiotics in the adsorbent is conducted only through easy solvent drip washing, the use amount of organic solvent is greatly reduced, the analyzing time is shortened, and the passive sampling instrument is suitable for passive sampling and detecting of macrolide antibiotics in the actual water.

Description

technical field [0001] The invention belongs to the technical field of sampling and determination of antibiotics, and more specifically relates to a passive sampler for determining macrolide antibiotics in water and its application. Background technique [0002] Antibiotics are an important class of pollutants in the water environment and have a wide range of sources. Monitoring their environmental residue levels is of great significance for ecological and health risks. Antibiotics include synthetic compounds (such as sulfonamides and quinolones) and natural compounds (such as penicillins, tetracyclines, and macrolides). According to their different chemical structures, antibiotics can be divided into: quinolones, β-lactams, chloramphenicols, sulfonamides, macrolides, cephalosporins, tetracyclines, aminoglycosides, etc. There have been many reports on antibiotic residues in the water environment, with concentrations ranging from ng / L to μg / L. Although the residual levels o...

Claims

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Application Information

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IPC IPC(8): G01N30/88G01N30/06G01N1/10
CPCG01N1/10G01N30/06G01N30/88
Inventor 鲜啟鸣邓超韦恩泽曹雨
Owner NANJING UNIV
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