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Application of graphene quantum dots to prevention and treatment of osteoporosis

A graphene quantum dot, osteoporosis technology, used in bone diseases, carbon active ingredients, drug combinations, etc.

Inactive Publication Date: 2016-07-06
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It has been reported that graphene can promote the osteogenic differentiation of human mesenchymal stem cells (hMSCs), however, there are no related reports on its effect on osteoclasts and the overall bone mass of experimental animals

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  • Application of graphene quantum dots to prevention and treatment of osteoporosis
  • Application of graphene quantum dots to prevention and treatment of osteoporosis
  • Application of graphene quantum dots to prevention and treatment of osteoporosis

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Embodiment Construction

[0025] Preferred embodiments of the present invention are described in detail below. For the experimental methods that do not specify specific conditions in the examples, usually follow the conventional conditions or the conditions suggested by the manufacturer.

[0026] BMMs are mouse mononuclear macrophages, which can differentiate into osteoclasts under the stimulation of RANKL and M-CSF, and are commonly used cell models to study the biological behaviors of osteoclast differentiation, fusion, maturation, and osteophagy. . At the same time, osteoclasts are closely related and coupled with osteoblasts, bone cells, and stromal cells, and are important regulatory elements for bone homeostasis and electrolyte homeostasis in the body. Osteoporosis is often caused by excessive bone resorption as a result of overactivation of osteoclasts. Therefore, the present invention uses BMMs as a cell model to study the effect of graphene quantum dots on RANKL-induced osteoclast formation,...

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Abstract

The invention discloses application of graphene quantum dots to prevention and treatment of osteoporosis. The application of the graphene quantum dots to prevention and treatment of osteoporosis concretely comprises application of the graphene quantum dots to preparation of a drug for inhibiting fusion or differentiation and maturation of osteoclast precursor cells, application of the graphene quantum dots to preparation of a drug for resisting the bone resorption capacity of mature osteoclast, application of the graphene quantum dots to preparation of a drug for inhibiting differentiation and fusion of osteoclast or expression of ripening-associated genes, application of the graphene quantum dots to preparation of a drug for inhibiting TRAP enzyme activity of osteoclast, and application of the graphene quantum dots to preparation of a drug for inhibiting fusion of osteoclast precursor cells to form multinucleated mature osteoclast; an effective dose of the graphene quantum dots can inhibit differentiation and maturation of RANKL induced BMMs cells to osteoclast in a concentration-dependent manner, inhibit bone resorption capacity of osteoclast obtained by differentiation and maturation of the RANKL induced BMMs cells, and further inhibit fusion of osteoclast; besides, the graphene quantum dots can obviously reduce expression of osteoclast differentiation specific genes, therefore the graphene quantum dots finally achieve the function of preventing and treating osteoporosis, and further can be applied to prevention and treatment of osteoporosis.

Description

technical field [0001] The invention relates to the technical field of prevention and treatment of osteoporosis, in particular to the application of graphene quantum dots in the prevention and treatment of osteoporosis. Background technique [0002] Osteoporosis (Osteoporosis, OP) is a systemic, progressive bone disease marked by decreased bone mass and bone mineral density. In OP patients, the bone mineral density (BMD) decreases, the bone microstructure is destroyed, and the amount and type of protein are changed, which easily leads to fracture. The disease is very common in postmenopausal women and the elderly over 75 years old, and it is an important factor that threatens the health of the elderly and reduces the quality of life. [0003] Osteoclasts (Osteoclast, OC) are differentiated from myeloid mononuclear cells of the hematopoietic stem cell line, and are the only physiological multinucleated giant cells in the human skeletal system that can absorb and reshape bone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/44A61P19/10
CPCA61K33/44
Inventor 罗阳窦策董世武许建中
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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