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Novel medical application of ritonavir

A technology of ritonavir and new uses, which is applied in the field of new medical uses of ritonavir, and can solve the problems of slowing down the spread of HIV and unreported pharmacological effects

Inactive Publication Date: 2016-07-13
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Clinically, ritonavir mainly treats adult HIV-I infection, and is an oral effective inhibitor of human immunodeficiency virus-1 (HIV-1) and human immunodeficiency virus-2 (HIV-2) aspartic acid protease, blocking the The enzyme promotes the production of polyproteins required for morphologically mature HIV particles, so that HIV particles remain in an immature state, thereby slowing down the spread of HIV in cells to prevent the occurrence of new rounds of infection and delay the development of the disease, However, the pharmacological effects of ritonavir in the prevention or treatment of obesity, type II diabetes, diabetic nephropathy and non-alcoholic fatty liver have not been reported

Method used

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  • Novel medical application of ritonavir
  • Novel medical application of ritonavir
  • Novel medical application of ritonavir

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1 Ritonavir capsule preparation

[0014] Weigh 50.0g ritonavir and 150.0g carboxymethyl starch sodium, mix well and pass through a 100 mesh sieve, add an appropriate amount of 3% PVP K30 Appropriate amount of water solution to prepare soft material, granulate with 20-mesh sieve, dry at 60°C for 3 hours, sieve with 18-mesh sieve for granulation, add 2.0g of magnesium stearate, mix well and pack into capsules, adjust the weight of the capsules to about 200mg.

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Abstract

The invention provides a novel medical application of ritonavir, in particular to the application of ritonavir in drugs for preventing or treating obesity, type II diabetes, diabetic nephropathy and non-alcoholic fatty liver disease.The oral administration dosage range is 50-2000 mg, and preferably 50-1000 mg.

Description

technical field [0001] The invention belongs to the field of chemical medicine, and relates to a new medical application of ritonavir; in particular, ritonavir inhibits the expression of high mobility group protein B1 (high mobility group protein, HMGB1), so as to prevent or treat obesity, type II diabetes, Diabetic nephropathy and non-alcoholic fatty liver and other related metabolic disorders. Background technique [0002] Type 2 diabetes is adult-onset diabetes, accounting for more than 90% of diabetic patients. People with type 2 diabetes are obese and develop insulin resistance, resulting in decreased sensitivity to insulin. Diabetic nephropathy is an important complication of diabetes, and nearly 40% of patients with late diabetes will develop diabetic nephropathy. Obesity is an unhealthy state of body fat accumulation and weight gain due to calorie intake exceeding consumption. The incidence of obesity is increasing rapidly in both developed countries and developin...

Claims

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Application Information

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IPC IPC(8): A61K31/427A61P1/16A61P3/04A61P3/10A61P13/12
CPCA61K31/427
Inventor 蒋王林张广华纪云霞叶亮朱海波
Owner BINZHOU MEDICAL COLLEGE