Medicine composition containing glucosamine and used for articular cavity injection

Abstract

The invention discloses medicine composition containing glucosamine and used for articular cavity injection. The medicine composition contains glucosamine hydrochloride and sodium hyaluronate, wherein the concentration of glucosamine hydrochloride ranges from 5% to 20%, the molecular weight of sodium hyaluronate is 800,000-2000,000 Dalton and the concentration of sodium hyaluronate is 0.5%-1.5%. The medicine composition has the advantages that micromolecular glucosamine is rapidly absorbed and has a rapid repairing function, also has the advantages of good viscoelasticity and buffering property relative to high-molecular-weight sodium hyaluronate and capability of promoting slow release of glucosamine and can be used for treating arthritis through articular cavity injection.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for intra-articular injection containing glucosamine. Background technique [0002] Osteoarthritis (OA), also known as degenerative joint disease, is a type of joint disease caused by multiple factors, with the degeneration of articular cartilage becoming basic pathological changes, and it is more common in middle-aged and elderly patients. The prevalence rate can reach 50% in people over 60 years old, and 80% in people over 75 years old. The disability rate of the disease can be as high as 53%. [0003] With the aging of the global population, the incidence of osteoarthritis is increasing year by year. China is a "superpower" for osteoarthritis. About 130 million people are suffering from osteoarthritis. In addition to affecting exercise capacity and quality of life, resulting in depression and anxiety, osteoarthritis also has a huge...

AI Technical Summary

Problems solved by technology

In the joint synovial fluid of patients with arthritis, the molecular weight, concentration and viscoelasticity of sodium hyaluronate are significantly reduced. Directly administering high molecular weight sodium hyaluronate into the joint cavity can re-form a natural barrier and prevent further destruction and disappearance of the cartilage matrix; Improve the biological function of the synovial membrane in pathological conditions, reduce or eliminate joint friction and pain, but the repair speed is slower and the course of treatment is longer

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