A microfluidic ion source chip and its preparation method

Abstract

Provided are a microfluid ion source chip (500) and a preparation method therefor. The microfluid ion source chip comprises a discrete phase layer, a first continuous phase layer and a spraying port. The discrete phase layer comprises a discrete phase storage pool (205) and a discrete phase flow channel (206). The first continuous phase layer comprises a first continuous phase storage pool (207) and a first continuous phase flow channel (208). The first continuous phase flow channel (208) starts from the first continuous phase storage pool (207) and is divided into two first continuous phase flow channel branches (2081, 2082) at a set position. The two first continuous phase flow channel branches (2081, 2082) are converged at a spraying port (204). The discrete phase flow channel (206) is in communication with the discrete phase storage pool (205) and the spraying port (204), and the discrete phase flow channel (206) is located between the two first continuous phase flow channel branches (2081, 2082).

Description

【Technical field】 [0001] The invention relates to a microfluidic ion source chip and a preparation method thereof. 【Background technique】 [0002] Microfluidic chips, especially integrated microfluidic chips with high-density, large-scale, high-throughput, and multi-functional features, have played an important role in the fields of chemistry and biology. Compared with macro-scale experimental setups, this technique significantly reduces sample consumption and improves reaction efficiency. At the same time, it also reduces the pollution of the waste generated by the experiment to the environment; the parallel advantage of the integrated microfluidic chip operation can realize the high-throughput and automatic control of the experiment; and it can be precisely controlled by micro-structures such as micro-valve and micro-pump. This makes microfluidic chips have irreplaceable advantages in the field of analysis. [0003] Mass spectrometry is an analytical method for measuring...

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Problems solved by technology

[0005] Since the current PDMS-based microfluidic chip coupled with mass spectrometry needs to be cut on both sides of the micron-scale flow channel to form a spray tip, this brings huge cutting difficulties to the processing and fabrication of the microfluidic chip.

At present, the microfluidic chip ion source used for mass spectrometry only has the design of liquid flow channel, and lacks the function of gas path assisted atomization; moreover, the microfluidic chip ion source used with mass spectrometry needs to apply high voltage to achieve sample ionization At the same time, a liquid-driven device is required to realize the injection of liquid samples. These shortcomings have severely restricted the miniaturization of mass spectrometry-coupled microfluidic chips.

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