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A rapid screening method for 40 banned antibiotics in cosmetics

A technology for antibiotics and cosmetics, applied in measurement devices, material analysis by electromagnetic means, instruments, etc., can solve problems such as skin irritation, health risks, microbial resistance, etc., to improve detection efficiency, reduce detection costs, and ensure accuracy. sexual effect

Active Publication Date: 2017-09-08
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Quinolone antibiotics, nitrofuran antibiotics, chloramphenicol antibiotics, and nitroimidazole antibiotics are all four types of antibiotics that are easily added to cosmetics. Adding antibiotic ingredients to cosmetics can significantly improve their mite and acne removal effects. It also has a certain curative effect on folliculosis, acne, and rosacea, but long-term use or contact can irritate the skin, cause rashes, allergies or contact dermatitis, cause adverse reactions to the central nervous system and intestinal tract, and even cause cancer and teratogenicity In severe cases, it can lead to drug resistance of microorganisms and cause health hazards

Method used

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  • A rapid screening method for 40 banned antibiotics in cosmetics
  • A rapid screening method for 40 banned antibiotics in cosmetics
  • A rapid screening method for 40 banned antibiotics in cosmetics

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Experimental program
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Embodiment 1

[0047] 1. Instruments and devices

[0048] Ion mobility spectrometer host (USA EXCELLIMS company, model GA2100, use tryptophan and citric acid to calibrate the instrument in positive and negative ion modes before use), including ion gate controller, air filter device, high-resolution ion mobility analyzer , Faraday cup detector, instrument control and data processing system; standard wall borosilicate glass blank (outer diameter 1.5mm, inner diameter 0.86mm); microelectrode drawing instrument (SUTTER Company, USA, model P-1000).

[0049] 2. Reagents and materials

[0050]Methanol, acetonitrile (U.S. Fisher Company) and formic acid (U.S. Sigma-Aldrich Company) are chromatographically pure; tryptophan and citric acid (U.S. Sigma-Aldrich, prepared with methanol to 10 μg / mL for instrument calibration); 40 banned antibiotics (nalidixic acid, flumequine, danoxacin, mabofloxacin, lomefloxacin, sparfloxacin, pazufloxacin, nafloxacin, ciprofloxacin, moxifloxacin, ofloxacin Star, difl...

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Abstract

The invention discloses a method for quickly screening 40 prohibited antibiotics in cosmetics, comprising the following steps: (1) making an in-situ spray ionization device: including drawing borosilicate glass capillary tubes and assembling the in-situ spray ionization device ; (2) Detection by ion mobility spectrometry: use a metal microelectrode to dip a cosmetic sample, insert a borosilicate glass capillary filled with methanol in advance, place it on the front end of the electrospray injection port of the ion mobility spectrometer host, Set the parameters of the ion mobility spectrometer mainframe, the sample is ionized, enters the migration tube for separation, and then is detected by the Faraday cup detector to obtain the corresponding experimental spectrum. For the samples with prohibited antibiotics screened by ion mobility spectrometry, high-performance liquid chromatography-mass spectrometry / mass spectrometry was further used for confirmation. The method of the invention is accurate and reliable, and while ensuring the accuracy of the detection data, the detection cost is greatly reduced and the detection efficiency is improved.

Description

technical field [0001] The invention relates to a detection method, in particular to a method for quickly screening 40 prohibited antibiotics in cosmetics by ion mobility spectrometry. Background technique [0002] Antibiotics are a class of prescription drugs. Long-term use can cause adverse reactions such as contact dermatitis, manifested as erythema, edema, erosion, desquamation, exudation, itching, burning, etc. my country's "Hygienic Standards for Cosmetics" (2007 edition) stipulates that antibiotic ingredients are prohibited ingredients in cosmetics, and the European Union also stipulates that antibiotics must not be added to cosmetics. Therefore, adding antibiotics to cosmetics is a violation. [0003] Quinolone antibiotics, nitrofuran antibiotics, chloramphenicol antibiotics, and nitroimidazole antibiotics are all four types of antibiotics that are easily added to cosmetics. Adding antibiotic ingredients to cosmetics can significantly improve their mite and acne rem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/64
Inventor 马强孟宪双白桦郭项雨
Owner CHINESE ACAD OF INSPECTION & QUARANTINE