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A kind of notoginseng total saponins composition and its preparation method and application

A technology of Panax notoginseng saponins and Panax notoginseng saponins, which is applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve the problem of lack of comprehensive and systematic research on the corresponding mechanism of synergistic or antagonistic effects of ingredients, complex ingredients, Adverse reactions and other problems, to achieve obvious anti-arteriovenous thrombosis effect, high content of active ingredients, less impurities

Active Publication Date: 2019-01-25
HARBIN ZHENBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although many pharmaceutical preparations with Panax notoginseng saponins as the main component have been developed, the composition of the pharmaceutical preparations with Panax notoginseng saponins as the main component is complex, and it has not been studied clearly which component plays the main therapeutic role, and which components have toxic side effects. Leading to adverse reactions, there is no comprehensive and systematic research on whether there is synergy or antagonism among the various components and the corresponding mechanism of action
Since the clinical use of Panax notoginseng saponins preparations, there have been many adverse reaction records

Method used

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  • A kind of notoginseng total saponins composition and its preparation method and application
  • A kind of notoginseng total saponins composition and its preparation method and application
  • A kind of notoginseng total saponins composition and its preparation method and application

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Effect test

Embodiment 1

[0052] Embodiment 1 A kind of Panax notoginseng saponins composition

[0053] One, preparation method, comprises the following steps:

[0054] ⑴. Pre-treatment: sort the notches of notoginseng and remove impurities, put them in the medicine washing machine, clean them with purified water, dry them at 120°C, and crush the notches of notoginseng after drying until the crushed particle size is 3mm, to obtain material A before extraction;

[0055] (2) Extraction: Weigh the pre-extracted material A obtained in step (1), add 65% ethanol with 1 times the weight of material A and soak for 12 hours, collect ethanol, add 80% ethanol with 1.5 times the weight of material A to the dregs, and then After soaking at 30°C for 12 hours, collect ethanol, combine the ethanol collections twice, heat and reflux to extract and concentrate for 8 hours, then transfer the concentrated solution to a single-effect external circulation concentrated evaporator to concentrate under reduced pressure until ...

Embodiment 2

[0080] Embodiment 2 A kind of Panax notoginseng saponins composition

[0081] One, preparation method, comprises the following steps:

[0082]⑴. Pre-treatment: sort the notoginseng to remove impurities, put it in the medicine washing machine, clean it with purified water, dry it at 90°C, and crush the dried notoginseng to a particle size of 0.5mm. Obtain material A before extraction;

[0083] (2) Extraction: Weigh the pre-extracted material A obtained in step (1), add 75% ethanol twice the weight of material A to soak for 24 hours, collect the ethanol, add 95% ethanol twice the weight of material A to the dregs, and Collect ethanol after soaking at 15°C for 24 hours, combine the ethanol collections twice, heat and reflux to extract and concentrate for 10 hours, then transfer the concentrated solution to a single-effect external circulation concentrated evaporator to concentrate under reduced pressure until there is no alcohol smell, and a concentrated paste is obtained;

[0...

Embodiment 3

[0102] Embodiment 3 A kind of Panax notoginseng saponins composition

[0103] One, preparation method, comprises the following steps:

[0104] ⑴. Pre-treatment: sort the notches of notoginseng and remove impurities, put them in the medicine washing machine, clean them with purified water, dry them at 115°C, and crush the notches of notoginseng after drying to a particle size of 1mm , to obtain material A before extraction;

[0105] (2) Extraction: Weigh the pre-extraction material A obtained in step (1), add 70% ethanol which is 3 times the weight of material A and soak for 18 hours, collect the ethanol, then add 85% ethanol which is 2 times the weight of material A to the dregs, and then After soaking at 20°C for 18 hours, collect the ethanol, combine the ethanol collections twice, heat and reflux to extract and concentrate for 9 hours, then transfer the concentrated solution to a single-effect external circulation concentrated evaporator to concentrate under reduced pressur...

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Abstract

The invention provides a panax notoginseng total saponin composition and a preparation method and application thereof. The Panax notoginseng saponin composition provided by the invention contains 30-50% of ginsenoside Rg1, 25-40% of ginsenoside Rb, 7-16% of notoginsenoside R1, 2.7-8% of ginsenoside Re, Saponin Rd 0.5-7.0%, ginsenoside Rf 0.5-2%, ginsenoside Rh2 0.3-2.0, ginsenoside Rc 1-3, ginsenoside Rb3 0.3-2.5 and ginsenoside Rg 30.5-2.5%; Ginsenoside Rb1 and Panax notoginsenoside R1 account for 70-95% of the total weight of the active ingredients, and the sum of the content of ginsenoside Rb1 and notoginsenoside R1 is not less than 8 times the content of ginsenoside Rd. Compared with the commercially available Xueshuantong and Xuesaitong preparations, the Panax notoginseng saponin composition provided by the invention has more obvious anti-arteriovenous thrombosis effect and low toxicity and safety.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a composition of Panax notoginseng saponins, a preparation method and application thereof. Background technique [0002] Panax notoginseng, also known as Tianqi, is an Umbelliferae Araliaceae plant, mainly distributed in Yunnan, Guangxi, Jiangxi, Sichuan and other places. Chinese herbal medicine Panax notoginseng uses its root as a medicinal part. Its rhizome contains a variety of saponins, which can expand blood vessels, inhibit platelet aggregation, dissipate blood stasis and stop bleeding, reduce swelling and relieve pain. It is mainly used for hemoptysis, vomiting, epistaxis, blood in the stool, Metrorrhagia, hemorrhage due to trauma, tingling pain in chest and abdomen, swelling and pain in tumbling down. [0003] Saponin is one of the main active ingredients of Panax notoginseng, and it is also a relatively systematic chemical substance studied. Now 5...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P7/02
CPCA61K31/704A61K2300/00
Inventor 方同华项彦华周广红贾文娟王博葛一蒙
Owner HARBIN ZHENBAO PHARMA
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